A5027020056- Antioxidant Activity and Oxidative Stress
- High voltage insulation and dielectric phenomena
- Power Transformer Diagnostics and Insulation
- Essential Oils and Antimicrobial Activity
- Nutritional Studies and Diet
- Computational Drug Discovery Methods
- Lightning and Electromagnetic Phenomena
- Biomimetic flight and propulsion mechanisms
- Natural product bioactivities and synthesis
- Cancer therapeutics and mechanisms
- Phagocytosis and Immune Regulation
- Retinoids in leukemia and cellular processes
- Phytochemicals and Antioxidant Activities
- Diet and metabolism studies
- Phytochemistry and Biological Activities
- Fluid Dynamics and Turbulent Flows
- Pesticide Exposure and Toxicity
- Proteins in Food Systems
- RNA Research and Splicing
- Non-Destructive Testing Techniques
- Obesity, Physical Activity, Diet
- Micro and Nano Robotics
- Nuclear Structure and Function
- Photosynthetic Processes and Mechanisms
- Skin Protection and Aging
Dalian University
2025
Dalian University of Technology
2025
Southeast University
2025
University of Maryland, College Park
2023-2024
Peking University
2023-2024
Center for Life Sciences
2024
Hefei Normal University
2024
Kyushu Institute of Technology
2022-2024
National University of Singapore
2012-2023
Faculdade do Futuro
2022
Abstract Glioblastoma (GBM), the most malignant brain tumor with high prevalence, remains highly resistant to existing immunotherapies due significant immunosuppression within microenvironment (TME), predominantly manipulated by M2‐phenotypic tumor‐associated macrophages (M2‐TAMs). Here in this work, an M2‐TAMs targeted nano‐reprogrammers, MG5‐S‐IMDQ, is established decorating mannose molecule as targeting moiety well toll‐like receptor (TLR) 7/8 agonist, imidazoquinoline (IMDQ) on...
Abstract Food allergy (FA) has received increased attention in recent years. Multiple studies have highlighted the crucial role of short‐chain fatty acids (SCFAs) development IgE‐mediated FA. Here, a case‐control approach was employed to analyze SCFAs profiles children with FA, while an ovalbumin (OVA)‐sensitized mouse model utilized explore underlying mechanism by which mitigate Children food‐sensitized tolerance (FST) ( n = 20) or FA 20), and healthy controls (HC) were recruited profiles....
The current effort to valorize waste byproducts increase sustainability and reduce agricultural loss has stimulated interest in potential utilization of components as health-promoting supplements. Tomato seeds are often discarded tomato pomace, a byproduct processing, yet these known contain an array compounds with biological activity prebiotic potential. Here, extract from (TSE), acquired was evaluated for their ability effect changes on the gut microbiota using ex vivo strategy. results...
This study evaluated the fruits of Forsythia suspensa (Lianqiao), an important economic crop, for chemical components its water and ethanol extracts, inhibitory effects on SARS-CoV-2 virus spike protein binding to ACE2, inhibition ACE2 activity, capacity scavenge free radicals. A total 42 compounds were tentatively identified in extracts via HPLC-MS/MS analysis. The extract showed a greater but weaker than per-botanical-weight-concentration basis. phenolic content was found be at 45.19 mg...
Inadequate intake of lutein is relevant to a higher risk age-related eye diseases. However, has been barely incorporated into foods efficiently because it prone degradation and poorly bioaccessible in the gastrointestinal tract. Microfluidics, novel food processing technology that can control fluid flows at microscale, enable efficient encapsulation bioactive compounds by fabricating suitable delivery structures. Hence, present study aimed evaluate stability bioaccessibility encapsulated new...
This study evaluated the chemical composition of rosemary water extract (RWE) and its influence on mechanisms by which SARS-CoV-2 virus enters into cells as a potential route for reducing risk COVID-19 disease. Compounds in RWE were identified using UHPLC-MS/MS. The inhibitory effect was then binding between spike protein (S-protein) ACE2 separately activity/availability. Additionally, total phenolic content (TPC) free radical scavenging capacities against HO•, ABTS•+, DPPH• assessed....
Water and ethanol extracts of dried thyme (Thymus vulgaris) were analyzed for chemical composition, inhibition the SARS-CoV-2 spike protein–ACE2 interaction, ACE2 activity, free radical scavenging capacity. Thirty-two compounds identified in water extract (WE) 27 (EE) through HPLC-MS. The WE (33.3 mg/mL) EE (3.3 inhibited interaction by 82.6 86.4%, respectively. at 5 mg/mL activity 99%, 65.8%. Total phenolics determined to be 38.9 8.8 mg GAE/g EE, HO• capacities 1121.1 284.4 μmol TE/g...
Abstract Skin carotenoid status (SCS) measured by resonance Raman spectroscopy (RRS) may serve as an emerging alternative measurement for dietary carotenoid, fruit and vegetable (FV) intake although its application had not been assessed in a middle-aged older population Asia. This cross-sectional study aims to concurrently examine the use of SCS plasma carotenoids measure FV population, taking into consideration potential socio-demographic nutritional confounders. The recruited 103 adults...
Dill (Anethum graveolens L.) is a spice belonging to the Apiaceae family and widely used in various dishes. This study aims evaluate dill's potential preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infiltration alleviating disease (COVID-19) symptoms when infected. Thus, chemical compositions, SARS-CoV-2′s spike protein, angiotensin-converting enzyme (ACE2) receptor interaction along with ACE2 activity inhibition, total phenolic content, free radical scavenging...
Abstract The intricate orchestration of lipid production, storage, and mobilization is vital for cellular systemic homeostasis 1,2 . Dysfunctional plasma control represents the major risk factor cardio-metabolic diseases, leading cause human mortality 3,4 Within landscape, endoplasmic reticulum (ER) central hub synthesis secretion, particularly in metabolically active hepatocytes liver or enterocytes gut 5,6 Initially assembled ER lumen, lipid-ferrying lipoproteins necessitate cross-membrane...
EfpA, the first major facilitator superfamily (MFS) protein identified in Mycobacterium tuberculosis (Mtb), is an essential efflux pump implicated resistance to multiple drugs. EfpA-inhibitors have been developed kill drug-tolerant Mtb. However, biological function of EfpA has not yet elucidated. Here, we present cryo-EM structures complexed with lipids or inhibitor BRD-8000.3 at resolutions 2.9 Å and 3.4 Å, respectively. Unexpectedly, forms antiparallel dimer. Functional studies reveal that...
The pathogenesis of coronavirus disease 2019 (COVID-19) is facilitated by the binding severe acute respiratory syndrome 2 (SARS-CoV-2) spike protein to angiotensin-converting enzyme (ACE2) in a host; hence, interfering with interaction between SARS-CoV-2's and ACE2 could possibly reduce risk COVID-19. This study aimed analyze chemical compositions evaluate antiviral free radical scavenging effects parsley leaf extracts. Twenty-two compounds were tentatively identified, octadecenamide being...
Abstract Host-based antivirals could offer broad-spectrum therapeutics and prophylactics against the constantly-mutating viruses including currently-ravaging coronavirus, yet must target cellular vulnerabilities of without grossly endangering host. Here we show that master lipid regulator SREBP1 couples phospholipid scramblase TMEM41B to constitute a host “metabolism-to-manufacture” cascade maximizes membrane supplies support coronaviral genome replication, harboring biosynthetic enzymes...
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Chemical Constituents of Parsley (Petroselinum crispum) Leaf Extract and Its Potential in Mitigating the Effects Viral Infections"Ethan Y. LeeEthan LeeMore by Ethan Lee, Zhihao LiuZhihao LiuMore Liuhttps://orcid.org/0000-0003-1644-0679, Yanfang LiYanfang LiMore Lihttps://orcid.org/0000-0003-2761-0282, Thomas T. WangThomas WangMore Wanghttps://orcid.org/0000-0003-2299-9452,...