A5059311139- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Chromatin Remodeling and Cancer
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- interferon and immune responses
- Cancer Mechanisms and Therapy
- Sarcoma Diagnosis and Treatment
- Cell Image Analysis Techniques
- Extracellular vesicles in disease
- Brain Metastases and Treatment
- Epigenetics and DNA Methylation
- Testicular diseases and treatments
- Histiocytic Disorders and Treatments
- Retinal Diseases and Treatments
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Renal and related cancers
- Circular RNAs in diseases
- Neuroscience and Neural Engineering
- Oral and Maxillofacial Pathology
- Ferroptosis and cancer prognosis
- 3D Printing in Biomedical Research
- Tumors and Oncological Cases
University Hospital Münster
2019-2025
University Hospital and Clinics
2024
University Medical Center
2024
Hospital Universitário de Brasília
2013-2022
Hepatoblastoma is the most common pediatric cancer of liver and majority cases display activating mutations in Wnt/β-catenin pathway. Understanding complex milieu tumor microenvironment has resulted promising new therapies for adult cancers, but similar approaches cancers are still lacking. We aimed to provide a comprehensive analysis hepatoblastoma unveiling its spatial architecture key signaling mechanisms. Single-cell/-nucleus RNA-seq (n=15), transcriptomics (n=22), multiplex...
Abstract Hepatoblastoma, the most prevalent pediatric liver cancer, almost always carries a WNT-activating CTNNB1 mutation, yet exhibits notable molecular heterogeneity. To characterize this heterogeneity and identify novel targeted therapies, we perform comprehensive analysis of hepatoblastomas tumor-derived organoids using single-cell RNA-seq/ATAC-seq, spatial transcriptomics, high-throughput drug profiling. We two distinct tumor epithelial signatures: hepatic ‘fetal’ WNT-high ‘embryonal’,...
The BAF (BRG1/BRM-associated factor) chromatin remodelling complex is essential for the regulation of DNA accessibility and gene expression during neuronal differentiation. Mutations its core subunit SMARCB1 result in a broad spectrum pathologies, including aggressive rhabdoid tumours or neurodevelopmental disorders. Other mouse models have addressed influence homo- heterozygous loss Smarcb1, yet impact specific non-truncating mutations remains poorly understood. Here, we established new...
Cancer metabolism influences multiple aspects of tumorigenesis and causes diversity across malignancies. Although comprehensive research has extended our knowledge molecular subgroups in medulloblastoma (MB), discrete analysis metabolic heterogeneity is currently lacking. This study seeks to improve understanding phenotypes MB their impact on patients' outcomes.Data from four independent cohorts encompassing 1,288 patients were analysed. We explored characteristics 902 (ICGC MAGIC cohorts)...
SUMMARY Hepatoblastoma, the most prevalent pediatric liver cancer, almost always carries a WNT-activating CTNNB1 mutation, yet exhibits notable molecular heterogeneity. To characterize this heterogeneity and identify novel targeted therapies, we performed comprehensive analysis of hepatoblastomas tumor-derived organoids using single-cell RNA-seq, spatial transcriptomics, ATAC-seq high throughput drug profiling. We identified two distinct tumor epithelial signatures: hepatic ‘fetal-like’...
Abstract INTRODUCTION Exploring tumor-neuronal interactions is essential for comprehending brain tumor proliferation, chemotherapy resistance, and patient survival. While glioma research has made significant strides, our understanding of in pediatric tumors, notably Embryonal Tumors with Multilayered Rosettes (ETMRs), remains limited. METHODS To elucidate ETMRs, we developed a 3D model by co-aggregating the human ETMR cell line BT-183 induced pluripotent stem cells (iPSCs) allowing them to...
Abstract Atypical teratoid/rhabdoid tumors (AT/RT) are the most common malignant brain during infancy. They split into four molecular types. The major three (AT/RT-SHH, AT/RT-TYR, and AT/RT-MYC) all carry mutations in SMARCB1, fourth smaller type is characterized by SMARCA4 (AT/RT-SMARCA4). AT/RT associated with a dismal outcome, 50% of patients suffer progress or recurrence tumor. Molecular mechanisms disease currently unclear. Here, we identified characteristics primaries recurrences,...
e21001 Background: Hepatic angiosarcoma is a high-grade malignant neoplasm, extremely rare in children and associated with poor prognosis. It reported English language less than fifty cases between 2 months 15- year-old at presentation. Due to the rarity of this tumor type, little known about effective systemic therapy. Many diferent schedules have been reported, comprising surgery only, neoadjuvant chemotherapy, wih adjuvant radiotherapy hepatic transplantation. The median survival rate...
Abstract BACKGROUND: Embryonal brain neoplasms like atypical teratoid rhabdoid tumor (ATRT) or embryonal with multilayered rosettes (ETMR) still have a very poor outcome despite intensive treatment including chemotherapy, irradiation and surgery. To date, precision oncology has identified clinically relevant innovative therapeutic targets only for minor subpopulation of pediatric patients, which may be due to current in vitro screens not recapitulating the cellular heterogeneity interactions...
Introduction: Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous group of malignancies with poor outcome. Because patients respond poorly to current treatment regimens, identification new therapeutic strategies required. In mouse tumor model, conditional deletion Smarcb1 encoding member the SWI/SNF chromatin remodeling complex causes majority mice develop mature lymphomas. The human counterpart, SMARCB1, bona fide suppressor gene associated development for...