A5107994911- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Mechanical Circulatory Support Devices
- Renal function and acid-base balance
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Central Venous Catheters and Hemodialysis
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Neuroscience of respiration and sleep
- Respiratory and Cough-Related Research
- Asthma and respiratory diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Sepsis Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Child and Adolescent Health
- Transplantation: Methods and Outcomes
- Ion Transport and Channel Regulation
- Metabolism and Genetic Disorders
- Cardiac Arrhythmias and Treatments
- Electrolyte and hormonal disorders
- Systemic Lupus Erythematosus Research
- Cardiac and Coronary Surgery Techniques
- Intensive Care Unit Cognitive Disorders
Northwestern University
2003-2023
Lurie Children's Hospital
2005-2023
Clinical Research Institute
2018
Duke University
2018
Northwestern Memorial Hospital
2001-2010
JK Research (United States)
2004
Polymer Aging Concepts (United States)
2004
Goodman Research Group (United States)
1995
Clinical Research Organization
1995
University of Minnesota
1984-1993
Maternal use of certain drugs during pregnancy can result in transient neonatal signs consistent with withdrawal or acute toxicity cause sustained a lasting drug effect. In addition, hospitalized infants who are treated opioids benzodiazepines to provide analgesia sedation may be at risk for manifesting withdrawal. This statement updates information about the clinical presentation exposed intrauterine and therapeutic options treatment is expanded include evidence-based approaches management...
Many mothers are inappropriately advised to discontinue breastfeeding or avoid taking essential medications because of fears adverse effects on their infants. This cautious approach may be unnecessary in many cases, only a small proportion contraindicated associated with Information inform physicians about the extent excretion for particular drug into human milk is needed but not available. Previous statements this topic from American Academy Pediatrics provided data concerning known...
Furosemide stimulates the renal synthesis of prostaglandin E2, a potent dilator ductus arteriosus. We administered this drug to 33 premature infants with respiratory-distress syndrome, determine whether it increased incidence patent Chlorothiazide, diuretic that does not stimulate E synthesis, was used as control in other infants. During study, arteriosus significantly higher (P<0.02) furosemide group (18 infants) than chlorothiazide (8 33). Eleven and seven required ductal ligation (P>0.2)....
Codeine has been prescribed to pediatric patients for many decades as both an analgesic and antitussive agent. is a prodrug with little inherent pharmacologic activity must be metabolized in the liver into morphine, which responsible codeine's effects. However, there substantial genetic variability of hepatic enzyme, CYP2D6, and, consequence, individual patient response codeine varies from no effect high sensitivity. Drug surveillance documented occurrence unanticipated respiratory...
Objective Extracorporeal membrane oxygenation (ECMO) has been used with increasing frequency in the treatment of acute respiratory failure pediatric patients. Our objective this study was to test hypothesis that ECMO improves outcome patients failure. Design Multicenter, retrospective cohort analysis. Setting Forty one intensive care units participated under auspices Pediatric Critical Care Study Group. Patients All admitted participating institutions during 1991 were included. congenital...
Mechanical ventilation of patients with severe lower airway obstruction presents significant risks; therefore, avoiding the intubation in these has been a principal goal clinical management. Noninvasive positive-pressure shown to be effective treating adults chronic obstructive pulmonary disease, but its use not studied prospectively children acute airways disease. The objective this study was determine whether noninvasive mask improved respiratory function asthma and other diseases.A...
Previous reports in the literature have documented that systemic infection with Candida albicans very premature infants is frequently fatal (54%) or associated significant morbidity survivors (25%). Five patients a mean birth weight of 829 g had diagnosis candidiasis during their stay newborn intensive care unit. All survived minimal sequelae following aggressive early treatment amphotericin B and 5-flucytosine. A review these five extremely 26 previously reported suggests following: (1)...
Medication administration errors that take place in the home are common, especially when liquid preparations used and complex medication schedules with multiple medications involved; children chronic conditions disproportionately affected. Parents other caregivers low health literacy and/or limited English proficiency at higher risk for making administering to their care. Recommended strategies reduce relate provider prescribing practices; literacy-informed verbal counseling (eg, teachback...
We investigated the relationship between duration of percutaneous central venous catheterization and occurrence catheter-related complications in critically ill children by survival analysis techniques. Data were collected prospectively analyzed for infectious noninfectious from 379 pediatric patients whom catheters had been placed ICU over a 45-month period. Cumulative rate revealed linear decrease number complication-free with time. The median catheter was projected to be 23.3 days. risk...
Objective We previously demonstrated that dexamethasone treatment before cardiopulmonary bypass in children reduces the postoperative systemic inflammatory response. The purpose of this study was to test hypothesis administration correlates with a lesser degree myocardial injury as measured by decrease cardiac troponin I release. Design A prospective, randomized, double-blind study. Setting surgery operating room and intensive care unit pediatric referral hospital. Subjects Twenty-eight...
Invasive hemodynamic monitoring is widely used in the care of critically ill children. In a prospective study, total 330 arterial catheters, 397 central venous and 47 pulmonary artery catheters were placed 467 children, between February 1981 September 1982. Complications observed included: bleeding seven 774 vascular catheterizations, obstruction three 377 sepsis 11 catheterizations. Of 21 complications noted, 71% occurred children less than 5 yr age. A 19 (4.1%) suffered bleeding,...
This Clinical Report was reaffirmed July 2023. Opioids are often prescribed to children for pain relief related procedures, acute injuries, and chronic conditions. Round-the-clock dosing of opioids can produce opioid dependence within 5 days. According a 2001 Consensus Paper from the American Academy Pain Medicine, Society, Society Addiction is defined as “a state adaptation that manifested by drug class specific withdrawal syndrome be produced abrupt cessation, rapid dose reduction,...
Medication overdoses are a common, but preventable, problem among children. Volumetric dosing errors and the use of incorrect delivery devices 2 common sources these preventable for orally administered liquid medications. To reduce increase precision drug administration, milliliter-based should be used exclusively when prescribing administering Teaspoon- tablespoon-based not used. Devices that allow precise dose administration (preferably syringes with metric markings) instead household...
Objective. Pregnancies in women with active rheumatic disease often result poor neonatal outcomes. Hydroxychloroquine (HCQ) reduces activity and flares; however, pregnancy causes significant physiologic changes that may alter HCQ levels lead to therapeutic failure. Therefore, our objective was evaluate concentrations during relate Methods. We performed an observational study of pregnant patients who were taking from a single center 2013–2016. Serum samples analyzed using high-performance...