A5091601756- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Autophagy in Disease and Therapy
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Screening and Detection
- Eosinophilic Esophagitis
- Ubiquitin and proteasome pathways
- Gut microbiota and health
- Endoplasmic Reticulum Stress and Disease
- Sirtuins and Resveratrol in Medicine
- Intestinal Malrotation and Obstruction Disorders
- Advanced biosensing and bioanalysis techniques
- Drug-Induced Ocular Toxicity
- Pluripotent Stem Cells Research
- Parasite Biology and Host Interactions
- CRISPR and Genetic Engineering
- Veterinary medicine and infectious diseases
- Plant Pathogens and Fungal Diseases
- Cancer therapeutics and mechanisms
- Histone Deacetylase Inhibitors Research
- Synthesis and Biological Evaluation
- Fungal Infections and Studies
- Liver Diseases and Immunity
- IL-33, ST2, and ILC Pathways
- Dermatology and Skin Diseases
Qilu Hospital of Shandong University
2018-2024
Shandong University
2020-2023
Zaozhuang Municipal Hospital
2023
West China Hospital of Sichuan University
2021
Tibet Autonomous Region People's Hospital
2021
Sichuan University
2021
Chongqing University
2021
Background and aims Endoscopic diagnosis of early esophageal squamous cell cancer (ESCC) is complicated dependent on operators' experience. This study aimed to develop an artificial intelligence (AI) model for automatic ESCC. Methods Non‐magnifying magnifying endoscopic images normal/noncancerous lesions, ESCC, advanced (AEC) were retrospectively obtained from Qilu Hospital Shandong University. A total 10,988 5075 cases chosen training validation. Another 2309 1055 collected testing. One...
Mitophagy plays a pro-survival or pro-death role that is cellular-context- and stress-condition-dependent. In this study, we revealed cyclovirobuxine D (CVB-D), natural compound derived from Buxus microphylla, was able to provoke mitophagy in lung cancer cells. CVB-D-induced potentiates apoptosis by promoting mitochondrial dysfunction. Mechanistically, CVB-D initiates enhancing the expression of receptor BNIP3 strengthening its interaction with LC3 mitophagy. Our results further showed p65,...
Lugol chromoendoscopy is the standard technique to detect an esophageal squamous cell carcinoma (ESCC). However, a high concentration of Lugol's solution can induce mucosal injury and adverse events. We aimed investigate optimal reduce events without degrading image quality.This was two-phase double-blind randomized controlled trial. In phase I, 200 eligible patients underwent esophagogastroduodenoscopy then were randomly (1:1:1:1:1) sprayed with 1.2%, 1.0%, 0.8%, 0.6%, or 0.4% solution....
The overexpression of adenosine triphosphate (ATP)-binding cassette (ABC) subfamily B member 1 (ABCB1; P-glycoprotein; MDR1) in some types cancer cells is one the mechanisms responsible for development multidrug resistance (MDR), which leads to failure chemotherapy. Therefore, it important inhibit activity or reduce expression level ABCB1 maintain an effective intracellular chemotherapeutic drugs. In this study, we found that rutaecarpine, a bioactive alkaloid isolated from Evodia...
Abstract Background Mucosal healing is one of the principal therapeutic targets for ulcerative colitis (UC). Mitochondria are dynamic organelles that undergo constant fusion and fission; however, process most conducive to mucosal remains unclear. This study investigated role mitochondrial fission in UC patients. Methods Quantitative polymerase chain reaction, Western blotting, immunostaining were used detect patients a dextran sulfate sodium–induced model. Colonic organoids investigate...
The increase in antibiotic resistance makes the eradication of Helicobacter pylori more difficult. Considering limitations application susceptibility-guided therapy, it is important to find an effective empirical regimen. aim study compare efficacy, safety, and cost-effectiveness clarithromycin-based bismuth-containing quadruple therapy (C-BQT) furazolidone-based (F-BQT) naïve H. positive patients.This was open-label, randomized controlled, crossover trial. trial comprised two phases. In C-F...
Emergomyces is a newly described dimorphic fungus genus; it may cause fatal infections in immunocompromised patients, but diagnosis often delayed. We report case of disseminated emergomycosis caused by the novel species orientalis kidney transplant recipient from Tibet. Infection was diagnosed early metagenomic next-generation sequencing.
Conventional gastrointestinal (GI) endoscopy reports written by physicians are time consuming and might have obvious heterogeneity or omissions, impairing the efficiency multicenter consultation potential. We aimed to develop validate an image recognition-based structured report generation system (ISRGS) through a database assess its diagnostic performance.First, we developed evaluated ISRGS combining real-time video capture, site identification, lesion detection, subcharacteristics...
Colorectal cancer (CRC) is the third leading malignant tumor in world, which has high morbidity and mortality. In this study we found that trichodermic acid (TDA), a secondary metabolite isolated from plant endophytic fungus Penicillium ochrochloronthe with variety of biological pharmacological activities, exhibited antitumor effects on colorectal cells vitro vivo. Our results showed TDA inhibited proliferation colon dose-dependent manner. induces sustained endoplasmic reticulum stress,...
This paper reported 3 cases of poisoning caused by chlorfenagyr. Chlorfenapyr has gradually increased in clinical practice. The early stage after is digestive tract symptoms, followed sweating, high fever, changes consciousness, myocardial enzymology, etc. Its main mechanism intoxication uncoupling oxidative phosphorylation. Since there no specific antidote poisoning, the fatality rate chlorfenapyr remains high. therapeutic measures are gastrointestinal decontamination, symptomatic and...
Visceral hypersensitivity is a common symptom in patients with post-infectious irritable bowel syndrome (PI-IBS), and change of the microbiota vital etiological factor it. Clostridium butyricum (C. butyricum) one probiotics which reported as active components treatment IBS, especially IBS diarrhea. Citrobacter rodentium rodentium) an enteropathogenic bacteria can produce self-limiting colitis mice, have been used to PI-IBS-like mice model. Whether C. could influence visceral gut PI-IBS still...
Abstract Background and Aim The study aims to evaluate the feasibility of body mass index (BMI)‐based individualized small bowel preparation for computed tomography enterography (CTE). Methods In this prospective randomized controlled study, patients undergoing CTE were randomly assigned group or standardized group. Those in given different volumes mannitol solution based on BMI (1000 mL with < 18.5 kg/m 2 , 1500 ≤ 25 2000 ≥ ) while all asked consume 1500‐mL solution. images reviewed by...
Background and aim Magnifying image-enhanced endoscopy was demonstrated to have higher diagnostic accuracy than white-light endoscopy. However, differentiating early gastric cancers (EGCs) from benign lesions is difficult for beginners. We aimed determine whether the computer-aided model diagnosis of can be applied videos rather still images. Methods A total 719 magnifying optical enhancement images EGCs, 1,490 lesions, 1,514 background mucosa were retrospectively collected train develop a...
Abstract Regional intestinal immune surveillance remains obscure. In this study, we integrated single-cell RNA sequencing and spatial transcriptomics to create a regional atlas of fetal adult intestines, consisting 59 cell subsets, which eight new subsets ILCs transition states were identified. Results revealed that microenvironment determines in-situ differentiation shapes the molecular characteristics, allowing different segments with diverse functions. We characterized expression mucins,...
Abstract Background Disseminated Strongyloides stercoralis hyperinfection is rarely described in immunocompetent individuals and can lead to fatal outcomes if not recognized diagnosed early. Non-specific clinical manifestations, such as pneumonia gastroenteritis, pose a diagnostic dilemma. Case presentation: We report case of 67-year-old Chinese male who presented with two months abdominal pain, fever, headache, vomiting, constipation, slight cough sputum. He had been good health no history...