A5101707954- Selenium in Biological Systems
- MicroRNA in disease regulation
- Trace Elements in Health
- Viral Infections and Immunology Research
- GDF15 and Related Biomarkers
- Neonatal and fetal brain pathology
- Circular RNAs in diseases
- Plant Parasitism and Resistance
- Pediatric Hepatobiliary Diseases and Treatments
- Sirtuins and Resveratrol in Medicine
- Thallium and Germanium Studies
- Geochemistry and Elemental Analysis
- Bee Products Chemical Analysis
- Systemic Lupus Erythematosus Research
- Inflammatory mediators and NSAID effects
- Cancer Mechanisms and Therapy
- Vitamin D Research Studies
- Geological and Geophysical Studies Worldwide
- Neural dynamics and brain function
- Glutathione Transferases and Polymorphisms
- Pharmacological Effects of Natural Compounds
- Immune cells in cancer
- Advanced MRI Techniques and Applications
- Plant-Microbe Interactions and Immunity
- Neonatal Respiratory Health Research
China Geological Survey
2024
Ningbo No. 2 Hospital
2014-2024
Ningbo No.6 Hospital
2024
Nanjing Agricultural University
2022
First Hospital of Jilin University
2019-2020
Jilin University
2019-2020
Binzhou People's Hospital
2018
Xi'an Jiaotong University
2011-2014
T-2 toxin, a mycotoxin produced by Fusarium species, has been shown to cause diverse toxic effects in animals and is also possible pathogenic factor of Kashin–Beck disease (KBD). The role mitochondria KBD recognized our recent research. aim this study was evaluate the toxin-induced human chondrocytes apoptosis understand pathogenesis KBD. toxin decreased viabilities concentration- time-dependent manners. Exposure can reduce activities mitochondrial complexes III, IV V, ΔΨm cellular ATP,...
Abstract Senescence of nucleus pulposus (NP) cells (NPC) is a major cause intervertebral disc degeneration (IVDD), so delay NPC senescence may be beneficial for mitigating IVDD. We studied the effect and mechanism silent information regulator 2 homolog 3 (SIRT3) on in vivo vitro. First, we observed SIRT3 expression normal degenerated with immunohistochemical immunofluorescence staining. Second, using lentivirus transfection, reactive oxygen species probe, senescence‐associated...
Necrotizing enterocolitis (NEC) is an acute intestinal condition accounting for severe mortality and morbidity in preterm infants. This study aimed to identify the possible roles of let-7d-5p neonatal rats with NEC. The differentially expressed genes (DEGs) related NEC were initially screened silico. After establishment rat models, measurement expression let-7d-5p, galectin-3 (LGALS3), Toll-like receptor 4 (TLR4), nuclear factor-κB (NF-κB) as well proinflammatory cytokines (TNF-α, IL-1β,...
Kashin-Beck disease (KBD) is a chronic endemic osteochondropathy with unclear pathogenesis. It degenerative similar to osteoarthritis, but different manifestations of cartilage damage. The aim this investigation was show the protein changes in KBD and identify candidate proteins order understand pathogenesis disease. Proteins were extracted from media primary cell cultures normal chondrocytes, separated by two-dimensional fluorescence difference gel electrophoresis (2-D DIGE). MALDI-TOF/TOF...
Abstract Background The purpose of the study was to understand function and expression ATF2 by JNK p38 signal pathways in chondrocytes apoptosis articular cartilage Kashin-Beck disease (KBD). Methods changes ATF2, mRNAs proteins were investigated between chondrocyte as well KBD normal. inhibitors used treatments prevent from patients. Results It found that protein levels p-p38, p-JNK, p-ATF2 increased human which is line with higher mRNA p38, compared both normal chondrocytes. In addition,...
MicroRNAs (miRNAs) are short, non-coding RNA molecules that control gene expression trough negative translational regulation. MiR-623 is a tumor suppressor, and it's function mechanism in breast cancer has not been reported.Exogenous overexpression of miR-623 suppressed cell proliferation, migration invasion, meanwhile, but promoted apoptosis. knockdown displayed opposite results. Overexpression resulted the downregulation CDK4/6 as well inhibition phosphatidylinositol-3-kinase (PI3K)/Akt...
Viral myocarditis (VMC) is an inflammatory cardiac disease caused by coxsackievirus B3 (CVB3) that leads to heart failure or sudden death. However, efficient therapeutic strategies for VMC remain lacking. Ginkgo biloba extract was previously demonstrated have anti-inflammatory activity and had been used in prevention therapy of some cardiovascular diseases (ie myocardial infarction), indicating may be a potential drug the treatment VMC. This study was, first time, investigate intervention...
The Bou Dahar Pb-Zn district, located in the Moroccan High Atlas, is a typical carbonate-hosted ore district (>30 Mt at 4 wt.% Pb, Zn). In situ trace element analysis was performed using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) on galena and cerussite from different types. generally enriched Ag Sb, secondarily Cu, with amount of Cd As, but extremely depleted Bi Tl. main substitution mechanism (Ag, Cu)+ + Sb3+ ↔ 2Pb2+, high Sb concentrations, further 2Sb3+ □...
Purpose: NKAP plays an important role in transcriptional repression, T-cell development, maturation and function acquisition, maintenance survival of hematopoietic stem cells, RNA splicing. In this study, we tried to explore the physiological breast cancer. Methods: We investigated expression cancer patients normal controls its correlation with by searching on GEPIA. knocked down MCF-7 cells RNAi technique studied effect cell proliferation, migration, invasion, apoptosis. And revealed under...
Examining the spontaneous activity to understand neural mechanism of brain disorders and establish neuroimaging-based disease-related biomarkers is a focus in recent resting-state functional MRI (fMRI) studies. The present study hypothesized that resting default mode network (DMN), which was used for characterizing human might be different patients with depressed Parkinson disease (dPD) compared non-depressed (ndPD) patients. To test hypothesis, we firstly employed Group independent...