A5102890765- Spaceflight effects on biology
- Tissue Engineering and Regenerative Medicine
- Sirtuins and Resveratrol in Medicine
- Healthcare and Venom Research
- Selenium in Biological Systems
- Mesenchymal stem cell research
- Diabetes Treatment and Management
- Bee Products Chemical Analysis
- Peptidase Inhibition and Analysis
- Adenosine and Purinergic Signaling
- Circadian rhythm and melatonin
- Muscle Physiology and Disorders
Soochow University
2019-2025
First Affiliated Hospital of Soochow University
2019-2025
Abstract Senescence of nucleus pulposus (NP) cells (NPC) is a major cause intervertebral disc degeneration (IVDD), so delay NPC senescence may be beneficial for mitigating IVDD. We studied the effect and mechanism silent information regulator 2 homolog 3 (SIRT3) on in vivo vitro. First, we observed SIRT3 expression normal degenerated with immunohistochemical immunofluorescence staining. Second, using lentivirus transfection, reactive oxygen species probe, senescence‐associated...
A reduction in bone mass around an implant is the main cause of loosening, especially postmenopausal osteoporosis patients. In osteoporosis, excessive oxidative stress, resulting osteoblast apoptosis, largely contributes to abnormal remodeling. Melatonin (MT) synthesized by pineal gland promotes differentiation and formation has been effectively used combat stress. Therefore, we hypothesized that MT attenuates apoptosis induced osteogenesis improves prostheses. Moreover, considering...
Intervertebral disc degeneration (IDD) remains a global healthcare challenge. Here, by analyzing clinical samples, we discover the loss of milk fat globule-EGF factor 8 (MFG-E8) from nucleus pulposus (NP) tissue-along with increased enzymatic breakdown glycosaminoglycans (GAGs)-as an overlooked for IDD development. Repairing degraded NP extracellular matrix (ECM) structurally-mimicking glycan glue to enrich MFG-E8 may counter degeneration. Accordingly, synthesize glucomannan octanoate (GMOC)...
Abstract Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown etiology characterized by degradation cartilage and bone, accompanied unimpeded proliferation synoviocytes altered phenotype. In the present study, we investigated involvement glucagon‐like peptide 1 (GLP‐1) receptor on human fibroblast‐like (FLS) in pathogenesis RA using selective GLP‐1 agonist exenatide, licensed drug used for treatment type 2 diabetes. Our results indicate that exenatide may play...
Stem cell-based tissue engineering therapy is the most promising method for treating volumetric muscle loss. Human amniotic mesenchymal cells possess characteristics similar to those of embryonic stem cells. In this study, we verified cell human by flow cytometry analysis, and osteogenic adipogenic differentiation. Through induction with DNA demethylating agent 5-azacytidine, can undergo myogenic differentiation express skeletal cell-specific markers such as desmin MyoD. The Wnt/β-catenin...