A5100425685- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- PI3K/AKT/mTOR signaling in cancer
- FOXO transcription factor regulation
- Cancer survivorship and care
- Cancer therapeutics and mechanisms
- Palliative Care and End-of-Life Issues
- Neutropenia and Cancer Infections
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Viral-associated cancers and disorders
- Gastric Cancer Management and Outcomes
- Pharmacogenetics and Drug Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Ovarian cancer diagnosis and treatment
- Metabolism, Diabetes, and Cancer
- Innovations in Medical Education
- Healthcare professionals’ stress and burnout
- Nausea and vomiting management
- Nanoparticle-Based Drug Delivery
- Autophagy in Disease and Therapy
- Family Support in Illness
- Diversity and Career in Medicine
Sun Yat-sen University
2014-2025
Sun Yat-sen University Cancer Center
2014-2025
State Key Laboratory of Oncology in South China
2014-2020
United States Food and Drug Administration
2013
Center for Drug Evaluation and Research
2013
Shijiazhuang Yiling Pharmaceutical (China)
2011
Hebei Chemical and Pharmaceutical College
2011
PD-L1 expression is a feature of Epstein-Barr virus (EBV) associated malignancies such as nasopharyngeal carcinoma (NPC). Here, we found that EBV-induced latent membrane protein 1 (LMP1) and IFN-γ pathways cooperate to regulate programmed cell death ligand (PD-L1). Expression was higher in EBV positive NPC lines compared with negative lines. could be increased by exogenous endogenous induction LMP1 induced PD-L1. In agreement, suppressed knocking down We further demonstrated up-regulated...
Paclitaxel, one of the most frequently used anticancer drugs, is dosed by body surface area, which leads to substantial inter-individual variability in systemic drug exposure. We evaluated clinical evidence regarding scientific rationale and benefit individualized paclitaxel dosing based on measured concentrations, known as therapeutic monitoring (TDM). In retrospective studies, higher exposure associated with greater toxicity efficacy treatment across several disease types regimens....
Abstract Purpose: Although gefitinib prolonged the progression-free survival (PFS) of patients with non–small cell lung cancer (NSCLC), unpredictable resistance limited its clinical efficacy. Novel predictive biomarkers explicit mechanisms are urgently needed. Experimental Design: A total 282 NSCLC treatment were randomly assigned in a 7:3 ratio to exploratory (n = 192) and validation 90) cohorts. The candidate polymorphisms selected Haploview4.2 Hapmap genotyped by MassARRAY system, feature...
Recent studies have shown the combination of C-reactive protein (CRP) and albumin (The modified Glasgow Prognostic Score, mGPS) had prognostic value in some solid tumors. However, no examined its role small-cell lung cancer (SCLC) patients. In this retrospective study, 460 consecutive SCLC patients were screened. Eligible patient was assigned a mGPS 0, 1, or 2 based on pre-treatment plasma CRP (0: ≤ 10 mg/L; 1: >10 mg/L ≥ 35 g/L; 2: > < g/L). Univariate multivariate analyses performed to...
The TNM staging system is far from perfect in predicting the survival of individual cancer patients because only gross anatomy considered. rates who have same stage disease vary across a wide spectrum. This study aimed to develop nomogram that incorporates other clinicopathologic factors for overall (OS) non-metastatic nasopharyngeal carcinoma (NPC) after curative treatments. We retrospectively collected clinical data 1520 NPC were diagnosed histologically between November 2000 and September...
<title>Abstract</title> Background Medical students are well-positioned to share scientifically valid and precise information about lung cancer prevention with their families. This practice plays a crucial role in enhancing awareness of core knowledge on treatment (CK-LCPT). Our research aims evaluate CK-LCPT among medical students' relatives identify influencing factors. Methods An electronic survey was administered China.. The collected respondents' basic details (11 items), (24 interest...
Abstract Background: JYP0322 is a potent, brain-penetrant and highly selective ROS1 inhibitor, demonstrating over 100-fold selectivity for compared to TRKA sub-nanomolar potency against the G2032R resistance mutation. designed simultaneously address key clinical challenges including mutations, tumor brain metastases while avoiding off-target neurotoxicity associated with TRK inhibition. Method: The Phase I study (NCT06128148) was evaluate safety, pharmacokinetics (PK), preliminary efficacy...
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and fatal malignancy, although gemcitabine administered as single or combined therapeutic agent. Our previous study demonstrated that ANP32E overexpression promoted PDAC cell proliferation. However, whether it affects treatment outcome clinical prognosis still unclear. In the present study, we aimed to determine negatively associated with of gemcitabine. We collected characteristics information from total 75 patients assess...
Abstract Background Burnout and career satisfaction has been extensively studied among U.S. European oncologists, although little is known about the situation Chinese oncologists. Therefore, we conducted this national survey to investigate prevalence of burnout Patients Methods Between September 2015 December 2016, a cross-sectional field was through Society Clinical Oncology Committee Rehabilitation Palliative Care. The full-length consisted 59 questions investigating personal professional...
Nasopharyngeal carcinoma (NPC) is a type of head-neck cancer with distinguishable geographic and racial distribution worldwide. Increasing evidence supports that the accumulation additional genetic epigenetic abnormalities important in driving NPC tumorigenic process. In this study, we aim to investigate association between EIF5A2 (Eukaryotic translation initiation factor 5A2) expression status clinical outcomes. The was investigated tissue microarray. Tissues were from 166 patients staging...
Background: Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs) have widely been used in advanced cancer. However, these drugs may also lead to serious adverse events. The present meta-analysis aimed determine the overall incidence and risk of deaths due VEGFR-TKIs with more detailed subgroup analysis. Materials methods: PubMed, Web Science, Cochrane databases were searched for randomized controlled trials (RCTs) that compared non-VEGFR-TKIs treatment solid...
This phase I/II study aimed to determine the maximum tolerated dose (MTD) of nanoparticle albumin-bound paclitaxel (nab ®-paclitaxel) plus cisplatin as treatment for metastatic nasopharyngeal carcinoma (NPC). Patients were enrolled into 1 3 cohorts, each with 21-day cycles: 1) intravenous (IV) nab-paclitaxel 260 mg/m2 on day 1; 2) IV 140 days and 8; 3) 100 1, 8, 15. All patients received 75 1. Treatment continued 4–6 cycles, or until progression unacceptable toxicity. If more than one-third...
Area under time-concentration curve (AUC) of docetaxel is related with its toxicity and efficacy. The aim this study to investigate the target range AUC in Chinese head neck cancer (HNC) patients.Eligible HNC patients were enrolled received at least 2 cycles docetaxel-based chemotherapy. A simplified pharmacokinetic (PK) strategy (2 monitored samples) was developed simulate using nonlinear mixed-effect modelling program. Preliminary pre-set as 2.5-3.7 µg·hr/mL according pooled analysis from...
Liposomal delivery of irinotecan could provide protection against drug hydrolysis, deliver more active lactone form to tumours and prolong exposure time. Nevertheless, conventional drug-loading technologies have typically resulted in undesired retention properties. To resolve the problem, a modified gradient loading method was developed resulting formulations were evaluated systemic manner.Irinotecan loaded into liposomes using novel sulfobutyl ether beta-cyclodextrin (sbe-CD) gradient. The...
Hepatotoxicity is a common side effect for patients treated with gefitinib, but the related pathogenesis unclear and lacks effective predictor management strategies. A multi-omics approach integrating pharmacometabolomics, pharmacokinetics pharmacogenomics was employed in non-small cell lung cancer to identify gefitinib-induced hepatotoxicity explore optional therapy substitution. Here, we found that rs4946935 AA, located Forkhead Box O3 (FOXO3) which well-known autophagic regulator, had...
Purpose: We explored the effect of hepatocyte growth factor (HGF)/Met signaling pathway on nasopharyngeal carcinoma (NPC) cells in vitro and vivo, investigated ability Met tyrosine kinase inhibitor (TKI) to block HGF-induced biological signaling. Experimental design: TKI PF-2341066 alone, or combination with cisplatin, was for its effects vivo. HGF/Met expression activation NPC were detected by using Western blot immunohistochemistry. Biological evaluation, including wound healing, cell...
A prior study showed blood type A/AB to be associated with an increased risk of nasopharyngeal carcinoma (NPC) compared subjects O. However, the relationship between ABO groups and prognosis NPC patients is still questionable. In addition, whether Epstein-Barr virus (EBV) infection different unclear.We conducted univariate multivariable Cox regression analyses based on a consecutive cohort 1,601 investigate above issues.There was no significant difference in overall survival (OS) (p=0.629),...
<b>Background:</b> The objective of this retrospective study was to evaluate the safety and efficacy percutaneous microwave ablation (MWA) for treating lung metastases from nasopharyngeal carcinoma (NPC). <b>Patients Methods:</b> From December 2012 November 2014, 17 patients (15 males, two females, averaged 45.7 years old) with NPC accepted computed tomography (CT)-guided MWA. average number 1.7 (range: 1–4), biggest tumor diameter 4.2 cm 0.8–4.2 cm). Nineteen nodules located in right 10...