A5101505353- Clostridium difficile and Clostridium perfringens research
- COVID-19 Clinical Research Studies
- Ocular Diseases and Behçet’s Syndrome
- Retinal Diseases and Treatments
- HER2/EGFR in Cancer Research
- Alzheimer's disease research and treatments
- Lung Cancer Treatments and Mutations
- Injury Epidemiology and Prevention
- Enterobacteriaceae and Cronobacter Research
- COVID-19 and healthcare impacts
- Antibiotic Resistance in Bacteria
- Autoimmune and Inflammatory Disorders
- Mycobacterium research and diagnosis
- COVID-19 epidemiological studies
- Cholinesterase and Neurodegenerative Diseases
- Trauma and Emergency Care Studies
- Transgenic Plants and Applications
- PI3K/AKT/mTOR signaling in cancer
- Computational Drug Discovery Methods
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Infectious Disease Case Reports and Treatments
- Actinomycetales infections and treatment
- Ion-surface interactions and analysis
- Autoimmune Bullous Skin Diseases
Institute of Process Engineering
2025
Xiangya Hospital Central South University
2020-2025
Central South University
2020-2025
National Clinical Research
2024
University of South China
2024
The First People's Hospital of Changde
2023
Beijing Tongren Hospital
2022-2023
Capital Medical University
2020-2023
Henan Provincial People's Hospital
2023
Beijing Children’s Hospital
2020-2022
Squamous metaplasia (SM) is common in smokers and associated with airway obstruction chronic obstructive pulmonary disease (COPD). A major mechanism of COPD thickening the small walls. We asked whether SM actively contributes to wall through alteration epithelial-mesenchymal interactions COPD. Using immunohistochemical staining, morphometry, fibroblast culture lung samples from patients; genome-wide analysis an vitro model SM; modeling human interactions, we provide evidence that SM,...
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Protein post‐translational modifications (PTMs) play crucial roles in various cellular processes. Despite their significance, only a few PTMs have been extensively studied at the proteome level, primarily due to scarcity of reliable, convenient, and low‐cost sensing methods. Here, we present straightforward effective strategy for detecting on short peptides through host‐guest interaction‐assisted nanopore sensing. Our results demonstrate that identity 13 types specific position...
We have subcloned and expressed the N-terminal portion of recently sequenced metabotropic GABA receptor, GABA(B)R1a. This region receptor contains a complement protein-like amino acid sequence. The purified 140-residue recombinant protein fragment was soluble stable. Mass spectrometry indicated formation four disulfide bonds, as expected if two modules (CPs, also known SCRs, Sushi domains) are formed. circular dichroism spectrum unusual characteristic CPs. Differential scanning calorimetry...
Clostridium difficile (C.difficile) is an exclusively anaerobic, spore-forming, and Gram-positive pathogen that the most common cause of nosocomial diarrhea becoming increasingly prevalent in community. Because C. strictly spores can survive for months external environment contribute to persistence diffusion within healthcare Antimicrobial therapy disrupts natural intestinal flora, allowing develop into propagules colonize colon produce toxins, thus leading antibiotic-associated...
While the cytogenetic and genetic characteristics of childhood acute lymphoblastic leukemias (ALL) are well studied, less clearly understood contributing epigenetic mechanisms that influence leukemia phenotype. Our previous studies others identified gene mutation (RAS) DNA methylation (FHIT) to be associated with most common subgroup ALL, high hyperdiploidy (having five more chromosomes). We screened profiles, using a genome-wide high-dimension platform 166 ALLs 6 normal pre-B cell samples...
Hexavalent chromium [Cr(VI)] has aroused the main interest of environmental health researchers due to its high toxicity. Liver is target organ Cr(VI), and purpose this study was explore whether mitophagy contributes Cr(VI)-induced hepatotoxicity demonstrate potential mechanisms. Cr(VI) exposure induced mitochondrial loss, energy metabolism disorders cell apoptosis, which were associated with occurrence excessive characterized by increased number green fluorescent...
Unbalanced and degraded mixtures (UDM) are very common in forensic DNA analysis. For example, signals from criminal suspects masked by a large amount of victims, or cell-free fetal (cffDNA) maternal plasma is high background DNA. Currently, detecting minor these complex challenging. We developed new set SNP-SNP microhaplotypes with short amplicons, we successfully genotyped them using the method amplification-refractory mutation system PCR (ARMS-PCR) combined SNaPshot technology based on...
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Purpose: To describe and analyze clinical characteristics of multifocal choroiditis with linear streaks (LSs). Methods: Eight cases LSs were retrospectively studied. Multimodal imaging was performed. Demographic data spherical equivalent collected. Axial length measured. Results: All are young myopic women a mean age 17.13 ± 3.64 years (range, 13–23 years), presenting vision loss distortion. Nine eyes high myopia −8.97 2.69 D −6.00 to 12.5 D; growing by 1.88 0.61 annually since wearing...
A novel compound C1 interacts with C-terminal juxtamembrane lysines of amyloid precursor proteins and inhibits γ-secretase production Aβ.
Alzheimer's disease (AD) is a serious public health crisis with only one current modifying treatment. The reduction of amyloid load by targeting γ-secretase (GS) has been leading approach in AD drug discovery and development. Despite the focus on GS inhibition, multiple inhibitors (GSIs) have failed clinical trials as result side effects including exacerbated cognitive decline. These are largely attributable to inhibition normal function. Standard enzyme target catalytic or allosteric sites...
It is generally believed that Carbapenem-resistant Enterobacterales (CRE) colonization primarily responsible for systemic infection in humans. However, there no consensus on whether decolonization should be recommended clinical practice. In China, the specific situation of CRE and consequent hospitalized patients necessitates further exploration. We conducted a cohort study analyzed various characteristics inpatients with intestinal colonization. A risk prediction model was established...
Abstract Purpose It is generally believed that Carbapenem-resistant Enterobacteriaceae (CRE) colonization primarily responsible for subsequent systemic infection in humans. In China, the specific situation of CRE and hospitalized patients necessitates further exploration. Methods We retrospectively analyzed data intestinal inpatients at Xiangya Hospital, Central South University, regarding demography, clinical pathogenic characteristics, treatment, outcome. A risk prediction model was...
The global outbreak of Coronavirus disease 2019 (COVID-19) was characterized as a pandemic by World Health Organization on March 11, 2020,1"WHO characterizes COVID-19 pandemic". Organization. Available at:https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-as-they-happen. Accessed May 7, 2020.Google Scholar and this has posed great impact the public health socioeconomic around world, especially developing countries. As 6, 2020, almost 3.6 million confirmed cases have been...