A5100432475- Plant Molecular Biology Research
- Plant-Microbe Interactions and Immunity
- Legume Nitrogen Fixing Symbiosis
- Plant Parasitism and Resistance
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Plant Gene Expression Analysis
- Nuclear Receptors and Signaling
- Plant pathogens and resistance mechanisms
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Hydrology and Sediment Transport Processes
- Plant Pathogens and Fungal Diseases
- Hydrology and Watershed Management Studies
- Agronomic Practices and Intercropping Systems
- Plant Reproductive Biology
- Plant Stress Responses and Tolerance
- Immunotherapy and Immune Responses
- Polysaccharides and Plant Cell Walls
- Protein Degradation and Inhibitors
- Bamboo properties and applications
- Soil erosion and sediment transport
Huazhong University of Science and Technology
2024-2025
Tongji Hospital
2024-2025
Jilin Academy of Agricultural Sciences
2022
Institut de Biologie de l'École Normale Supérieure
2013-2021
Inserm
2013-2021
Centre National de la Recherche Scientifique
2013-2021
State Key Laboratory of Genetic Engineering
2020
Centre National pour la Recherche Scientifique et Technique (CNRST)
2020
Fudan University
2013-2020
Institut National de Recherche en Santé Publique
2013
DNA methylation is an epigenetic mark that silences transposable elements (TEs) and repeats. Whereas the establishment maintenance of are relatively well understood, little known about their dynamics biological relevance in plant animal innate immunity. Here, we show some TEs demethylated transcriptionally reactivated during antibacterial defense Arabidopsis . This effect correlated with down-regulation key transcriptional gene silencing factors partly dependent on active demethylation...
Active DNA demethylation has emerged as an important regulatory process of plant and mammalian immunity. However, very little is known about the mechanisms by which active controls transcriptional immune reprogramming disease resistance. Here, we first show that Arabidopsis demethylase ROS1 promotes basal resistance towards Pseudomonas syringae antagonizing RNA-directed methylation (RdDM). Furthermore, demonstrate facilitates flagellin-triggered induction gene RMG1 limiting RdDM at 3'...
Abstract New treatment strategies are urgently needed for patients with advanced cervical cancer (CC). Here, a synergistic anti‐CC effect of novel combinatorial immunotherapy adoptively transferred autologous Vγ9Vδ2 T cells and αβ is shown. The pivotal role both circulating tumor‐infiltrating in immunity uncovered. Importantly, show not only through killing tumor directly, but also by promoting the activation tumoricidal activity syngeneic antigen presentation, which can be further boosted...
Significance MicroRNAs (miRNAs) are indispensable regulators of gene expression. Hyponastic Leaves 1 (HYL1) is a core component the microprocessor that processes primary miRNAs (pri-miRNAs) into mature miRNAs. Here we report noncanonical function HYL1 in protecting pri-miRNAs from unwanted nuclear exosome activities during processing. Our observations also suggest may contribute differently to Dicer-like (DCL1)-mediated maturation loop-to-base– and base-to-loop–processed pri-miRNAs. This...
Clinical trials have shown that immunotherapy based on Vγ9Vδ2 T cells (Vδ2 cells) is safe and well-tolerated for various cancers including cervical cancer (CC), but its overall treatment efficacy remains limited. Therefore, exploring the mechanisms underlying suboptimal of Vδ2 cell-based crucial enabling successful clinical translation.
Bromodomain-containing protein 2 (Brd2) is a nuclear serine/threonine kinase involved in transcriptional regulation. In 3T3-L1 adipocytes, Brd2 normally co-represses PPARγ (peroxisome proliferator-activated receptor gamma) and inhibits adipogenesis. Here, we show that over-expression preadipocytes their differentiation into while knockdown promotes adipogenic vitro forces cells to undergo adipogenesis independent of the MDI (methyisobutylxanthane, dexamethasone insulin) induction. this...
With the continuous improvement of mechanization level and development new crop varieties, optimal strip width for intercropping crops is important. In this study, field experiments were conducted to analyze effects different row spacings planting patterns on photosynthesis, chlorophyll fluorescence, related enzyme activities maize ear leaves in a maize–soybean system using two (wide–narrow rows 80–50 cm uniform ridges 65 cm) ratios (four four soybean; six soybean). The results showed that...
Abstract Active DNA demethylation has emerged as an important regulatory process of plant and mammalian immunity. However, very little is known about the mechanisms by which active controls transcriptional immune reprogramming disease resistance. Here, we first show that Arabidopsis demethylase ROS1 promotes basal resistance towards Pseudomonas syringae antagonizing RNA-directed methylation (RdDM). Furthermore, found facilitates flagellin-triggered induction gene RMG1 limiting RdDM at 3’...