A5013230917- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Oral and gingival health research
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Salivary Gland Disorders and Functions
- Immunodeficiency and Autoimmune Disorders
- Dental Radiography and Imaging
- HIV/AIDS oral health manifestations
- Systemic Lupus Erythematosus Research
- Dental Health and Care Utilization
- Immune Response and Inflammation
- Autoimmune and Inflammatory Disorders
- Streptococcal Infections and Treatments
- Inflammatory Bowel Disease
- Dental materials and restorations
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Oral health in cancer treatment
- Fatty Acid Research and Health
- S100 Proteins and Annexins
- Liver Disease Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- T-cell and B-cell Immunology
- Meta-analysis and systematic reviews
Griffith University
2018-2025
Karolinska Institutet
2009-2025
Universidade do Estado do Rio de Janeiro
2013-2022
Albert Einstein College of Medicine
2022
Montefiore Medical Center
2022
Yeshiva University
2021
Universidad Nacional de Córdoba
2006-2020
Consejo Nacional de Investigaciones Científicas y Técnicas
2020
Hospital Privado
2020
Creative Research Enterprises (United States)
2016
Background: Recent epidemiologic studies suggest that inflammation is the link between periodontal diseases and cardiovascular complications. This study aimed to evaluate effects of non‐surgical treatment on plasma levels inflammatory markers (interleukin [IL]‐6, C‐reactive protein [CRP], fibrinogen) in patients with severe periodontitis refractory arterial hypertension. Methods: Twenty‐two were examined randomly divided into two groups. The test group was composed 11 (mean age, 48.9 ± 3.9...
The aim of this study was to investigate the effect periodontal therapy on circulating concentration high-sensitivity capsule-reactive protein (hs-CRP), fibrinogen (FIB), interleukin (IL)-4, IL-6, IL-8, IL-10 and tumour necrosis factor-alpha (TNF-alpha) metabolic control in type 2 diabetes mellitus (T2DM) patients.Twenty-three T2DM patients with chronic periodontitis were enrolled study. Periodontal clinical parameters, namely visible plaque index, gingival bleeding probing, probing depth...
To compare the prevalence of periodontal disease and decayed, missing filled teeth (DMFT) index in patients with Crohn's (CD) ulcerative colitis (UC) those without these diseases.Ninety-nine CD (39.0 SD+/-12.9 years), 80 UC (43.3 SD+/-13.2) 74 healthy controls (40.3 SD+/-12.9) were compared for DMFT presence periodontitis. Probing pocket depth (PPD), clinical attachment loss (CAL), bleeding on probing (BOP), plaque measured all subjects. The periodontitis was defined as having CAL > or =3 mm...
To evaluate the effects of non-surgical periodontal treatment on left ventricular mass (LVM), arterial stiffness, systolic and diastolic blood pressure plasma levels inflammatory markers (C-reactive protein (CRP), fibrinogen interleukin-6) in refractory hypertension patients.This interventional prospective cohort pilot study included 26 patients (53.6 ± 8.0 years old) diagnosed with generalized chronic periodontitis. Subjects received according to their needs. Plasma systemic inflammation...
Background: We have previously found hyperreactive neutrophils, intrinsic or induced, in periodontitis patients by vitro quantitation of free oxygen radicals. The effects and cigarette smoking on blood parameters generally been described separately. Our aim was to compare these systemic smoking, separately combination, order study the hyperreactivity peripheral neutrophils. Methods: Blood cells acute‐phase proteins were studied 40 43 healthy controls. generation radicals from neutrophils...
Brito F, Almeida S, Figueredo CMS, Bregman R, Suassuna JHR, Fischer RG. Extent and severity of chronic periodontitis in kidney disease patients. J Periodont Res 2012; 47: 426–430. © 2011 John Wiley & Sons A/S Background Objectve: Chronic inflammatory diseases have been investigated as a possible source inflammation patients; however, there is shortage information about the prevalence such individuals. Therefore, aim this cross‐sectional study was to determine extent patients undergoing...
This pilot cohort study evaluated the effect of periodontal treatment on renal function, metabolic markers and asymmetric dimethylarginine (ADMA) in patients with pre-dialysis chronic kidney disease (CKD) presenting periodontitis.Twenty-six CKD severe periodontitis were selected. Periodontal parameters included plaque index, bleeding probing, probing pocket depth clinical attachment level. Estimated glomerular filtration rate (eGFR), triglycerides, total cholesterol, albumin ADMA levels at...
The aim of this case control study was to assess the association between extent and severity chronic periodontitis oral cavity and/or oropharyngeal cancer. group comprised 35 patients (mean age 56.1±8.4), diagnosed for 40 individuals 55.4±9.4) without diagnostic All were subjected a periodontal examination, including bleeding on probing, plaque index, gingival probing pocket depth (PPD), clinical attachment loss (CAL), decayed, extracted filled teeth index (DMFT). had significantly more...
INPLASY
The levels of interleukin-1beta (IL-1beta) have been reported to be higher in sites with periodontitis than healthy controls. This may the result a more severe inflammation and/or constitutional differences IL-1beta production. Our aim was test hypothesis that level gingival crevicular fluid (GCF) is characteristic trait periodontitis, regardless degree tissue destruction. As secondary aim, we investigated correlation between and neutrophil elastase. An untreated population used.GCF samples...
To verify a possible association between periodontitis and low-birth-weight babies.One hundred fifty-one mothers were examined. The case group included 76 (mean age 25.6 years), whose babies at birth weighed <2500 g had gestational (GA) <37 weeks, while 75 24.4 born with weight of >2500 GA>37 the control group. Data from collected Hospital registration records during an interview mother. periodontal examination measurements probing pocket depth (PPD) clinical attachment loss (CAL) in six...
This study determines the gingival crevicular fluid (GCF) levels of interleukin (IL)-1 beta, IL-2, IL-4, IL-8, interferon (IFN)-gamma and elastase activity in inflamed shallow deep periodontal sites from patients with generalized chronic (GCP) aggressive periodontitis (GAgP), to compare them subjects gingivitis. A secondary aim analyzes microbiologic profile these subjects.Cross-sectional clinical data were obtained 20 GCP, 17 GAgP, 10 gingivitis subjects. GCF samples collected paper strips...
Background: Our goal was to examine differences in clinical, microbiologic, and immunologic responses non‐surgical mechanical therapy patients with generalized chronic periodontitis (GCP) aggressive (GAgP). Methods: Twenty GCP 14 GAgP were evaluated. Clinical data, gingival crevicular fluid (GCF), subgingival plaque samples collected at baseline 3 months after periodontal treatment. Levels of 40 species measured using checkerboard DNA‐DNA hybridization. GCF interleukin (IL)‐1β, ‐4, ‐8...
This study aimed to measure the levels of GM-CSF, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IFN-γ and TNF-α in peri-implant crevicular fluid (PICF) saliva from patients with disease.Twenty two total edentulous were divided into groups: Mucositis (MU) bone loss around implants until first thread pocket depth ≤3 mm, Peri-implantitis (PI) at least one implant or more threads ≥4 mm. The clinical parameters evaluated probing depth, bleeding on probing, percentage plaque. PICF...
Objective To analyze the subgingival microflora composition of inflammatory bowel disease (IBD) patients with untreated chronic periodontitis and compare them systemically healthy controls also having periodontitis. Method Thirty IBD [15 Crohn's (CD) 15 ulcerative colitis (UC)] control individuals participated in study. All had been diagnosed From every patient, plaque was collected from four gingivitis sites paper points. Samples same category (gingivitis or periodontitis) each patient were...
Background: This study aimed to compare the effectiveness of non‐surgical periodontal treatment in improving status and reducing gingival crevicular fluid (GCF) levels interleukin (IL)‐1β IL‐18, elastase activity, matrix metalloproteinase (MMP)‐‐8 ‐‐9 periodontitis patients with without type 2 diabetes mellitus (T2DM). Methods: Twenty‐three T2DM (diabetes group) 26 systemically healthy subjects (control chronic participated this study. The clinical examination included visible plaque index,...
Matrix metalloproteinases (MMPs) and monocyte chemoattractants are key modulators of the biological mechanisms triggered in periodontium by mechanical forces. The gingival crevicular fluid (GCF) provides a non-invasive method to assess longitudinally release inflammatory mediators during orthodontic tooth movement. goal this study was examine GCF levels MMP-3, MMP-9, MMP-13 chemokines macrophage protein (MIP)-1β, chemoattractant (MCP)-1, regulated on activation normal T cells expressed...