A5090249143- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Bone health and osteoporosis research
- Immune Response and Inflammation
- Bone health and treatments
- Oral and gingival health research
- Salivary Gland Disorders and Functions
- HIV/AIDS oral health manifestations
- Streptococcal Infections and Treatments
- Diabetes and associated disorders
- Oral and Maxillofacial Pathology
- Advanced Glycation End Products research
- Dental Health and Care Utilization
- Bone Metabolism and Diseases
- Orthopaedic implants and arthroplasty
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Dental Implant Techniques and Outcomes
- Inflammatory mediators and NSAID effects
- Health, Nursing, Elderly Care
- Periodontal Regeneration and Treatments
- interferon and immune responses
- Immune cells in cancer
- Dental Radiography and Imaging
- Bone Tissue Engineering Materials
- Peroxisome Proliferator-Activated Receptors
Universidade Estadual Paulista (Unesp)
2013-2024
Centro Universitário de Araraquara
2010-2023
Universidade de São Paulo
2003-2014
Universidade Estadual de Campinas (UNICAMP)
2014
Fundação Faculdade de Odontologia
2009
The aim of this study was to investigate the effect periodontal therapy on circulating concentration high-sensitivity capsule-reactive protein (hs-CRP), fibrinogen (FIB), interleukin (IL)-4, IL-6, IL-8, IL-10 and tumour necrosis factor-alpha (TNF-alpha) metabolic control in type 2 diabetes mellitus (T2DM) patients.Twenty-three T2DM patients with chronic periodontitis were enrolled study. Periodontal clinical parameters, namely visible plaque index, gingival bleeding probing, probing depth...
Periodontitis is the most common lytic disease of bone and recognized as a complication diabetes. Lipid peroxidation (LPO) increased in diabetes may be related to modulation inflammatory response. LPO levels patients with periodontal have not been evaluated.The aim this study was evaluate its correlation status cytokines type 2 diabetic nondiabetic patients.This cross-sectional involving Brazilian recruited at State University São Paulo.The sample comprised 120 divided into four groups based...
Studies have suggested an important role of dyslipidemia, a condition with alterations in blood lipid levels, promoting additional effect on periodontal breakdown. Thus, this study aimed to explore the theoretical pathways associated dyslipidemia and periodontitis. We used data from 11,917 US adults complete examinations participating Third National Health Nutrition Examination Survey (NHANES III). Our hypothesis was tested using structural equation modelling (SEM). Dyslipidemia defined...
Objective: The aim of this study was to evaluate a possible synergism between AGE-RAGE and TLR4 signaling the role p38 MAPK NF-kB pathways on modulation expression inflammatory cytokines proliferation cells from innate adaptive immune response. Material Methods: T lymphocyte (JM) monocyte (U937) cell lines were stimulated with LPS AGE-BSA independently associated, both in presence absence inhibitors. Proliferation assessed by direct counting viability biochemical assay mitochondrial...
Background Lichen planus is a mucocutaneous disease with manifestation in the oral mucosa, gingiva being one of most affected regions. In some cases, lesion may be painful and lead to fragility tissues, so that precise diagnosis adequate treatment are indispensible factors for improving clinical condition. The aim this study was evaluate effectiveness plaque control improvement features symptoms lichen gingival involvement. Methods Twenty patients diagnosed confirmed by histopathological...
Background: This study aimed to compare the effectiveness of non‐surgical periodontal treatment in improving status and reducing gingival crevicular fluid (GCF) levels interleukin (IL)‐1β IL‐18, elastase activity, matrix metalloproteinase (MMP)‐‐8 ‐‐9 periodontitis patients with without type 2 diabetes mellitus (T2DM). Methods: Twenty‐three T2DM (diabetes group) 26 systemically healthy subjects (control chronic participated this study. The clinical examination included visible plaque index,...
Abstract Type 2 diabetes mellitus (T2DM), dyslipidemia and periodontitis are frequently associated pathologies; however, there no studies showing the peripheral blood transcript profile of these combined diseases. Here we identified differentially expressed genes (DEGs) circulating lymphocytes monocytes to reveal potential biomarkers that may be used as molecular targets for future diagnosis each combination pathologies (compared healthy patients) give insights into underlying mechanisms...
O isolamento social, uma experiência que se intensificou globalmente durante a pandemiade COVID-19, trouxe à tona desafios significativos para saúde mental e emocional de criançase adultos. Embora necessidade medidas preventivas tenha sido inegável, as consequênciaspsicológicas desse lançaram luz sobre importância das interações sociais obem-estar humano.
Abstract Objectives: This study evaluated the effect of magnesium dietary deficiency on bone metabolism and tissue around implants with established osseointegration. Materials methods: For this, 30 rats received an implant in right tibial metaphysis. After 60 days for healing implants, animals were divided into groups according to diet received. Control group (CTL) a standard adequate content, while test (Mg) same except 90% reduction magnesium. The sacrificed after 90 evaluation calcium,...
Background: Some haplotypes in the interleukin‐4 ( IL4 ) gene were reported to influence IL‐4 cytokine production and associated with inflammatory diseases. Association studies focusing on polymorphisms periodontal disease provided conflicting results. The aim of this study is investigate whether related chronic periodontitis a Brazilian population. Methods: –590(C/T) +33(C/T) identified by polymerase chain reaction (PCR) restriction fragment‐length polymorphism methods; variable number...
Objectives: This study evaluated the influence of oestrogen deficiency and its therapies on bone tissue around osseointegrated implants. Methods: Implants were placed in 66 female rats tibiae. The animals assigned into five groups: control (CTL), sham, ovariectomy (OVX), (EST), alendronate (ALE). While CTL was sacrificed 60 days after implant placement, other groups subjected to or sham surgery according group euthanized 90 days. Blood urine samples collected at sacrifice day for osteocalcin...
The over-production of reactive oxygen species (ROS) can cause oxidative damage to a large number molecules, including DNA, and has been associated with the pathogenesis several disorders, such as diabetes mellitus (DM), dyslipidemia periodontitis (PD). We hypothesise that presence these diseases could proportionally increase DNA damage. aim this study was assess micronucleus frequency (MNF), biomarker for damage, in individuals type 2 DM, PD. One hundred fifty patients were divided into...
Background: This study investigated the influence of estrogen deficiency and its treatment with alendronate on removal torque osseointegrated titanium implants. Methods: Fifty‐eight female Wistar rats received a implant in tibia metaphysis. After 60 days, which was needed for osseointegration, animals were randomly divided into five groups: control (CTLE; N = 10), sham surgery (SHAM; 12), ovariectomy (OVX; followed by hormone replacement (EST; (ALE; 12). The CTLE group sacrificed to confirm...
To evaluate the effect of periodontal therapy on clinical parameters as well total salivary peroxidase (TSP) activity and myeloperoxidase (MPO) in gingival crevicular fluid (GCF) patients with type 2 diabetes mellitus (DM2) systemically healthy individuals.Twenty DM2 subjects inadequate metabolic control (test group) 20 individuals (control group), both groups chronic periodontitis, were enrolled. Periodontal parameters, namely probing depth (PD), attachment level (CAL), visible plaque index...
The important inflammatory mediator interleukin-8 (IL-8) is responsible for the migration and activation of neutrophils. IL8 gene contains a functional single-nucleotide polymorphism (SNP) (rs4073) in its promoter region that may influence expression IL-8, which has been associated with diseases. purpose this study was to investigate association SNP susceptibility periodontitis. DNA extracted from buccal epithelial cells 500 individuals (control n = 224 periodontitis 276). Individuals were...
The peroxisome proliferator-activated receptor gamma (PPARG) gene encodes a transcription factor involved in the regulation of complex metabolic and inflammatory diseases. We investigated whether single nucleotide polymorphisms (SNPs) haplotypes PPARG could contribute with susceptibility to develop periodontitis alone or together type 2 diabetes mellitus (T2DM). Moreover, we evaluated gene-phenotype association by assessing subjects' biochemical periodontal parameters, expression other...
Interleukin 8 (IL-8) is a chemokine related to the initiation and amplification of acute chronic inflammatory processes. Polymorphisms in IL8 gene have been associated with diseases. We investigated whether -845(T/C) -738(T/A) single nucleotide polymorphisms (SNPs) gene, as well haplotypes they form together previously -353(A/T), are susceptibility periodontitis.DNA was extracted from buccal epithelial cells 400 Brazilian individuals (control n=182, periodontitis n=218). SNPs were genotyped...