A5016869122- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Plant Stress Responses and Tolerance
- DNA and Biological Computing
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Single-cell and spatial transcriptomics
- Aluminum toxicity and tolerance in plants and animals
- Modular Robots and Swarm Intelligence
- Advanced Memory and Neural Computing
- Time Series Analysis and Forecasting
- Gene expression and cancer classification
- Plant-Microbe Interactions and Immunity
- Plant Micronutrient Interactions and Effects
- Metaheuristic Optimization Algorithms Research
- Circular RNAs in diseases
- Traffic Prediction and Management Techniques
- Plant Pathogenic Bacteria Studies
- Plant nutrient uptake and metabolism
- Milk Quality and Mastitis in Dairy Cows
- Mental Health via Writing
- Advanced Graph Neural Networks
- Recommender Systems and Techniques
- Genetic Associations and Epidemiology
Inner Mongolia University
2025
Qufu Normal University
2022-2024
Guizhou University
2024
Guangxi University
2024
Heilongjiang University of Science and Technology
2024
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2024
Heilongjiang University
2024
Zunyi Medical University
2024
Shanghai Normal University
2023-2024
Affiliated Hospital of Nantong University
2021-2023
Limited data are available on metabolic responses of plants to copper (Cu)-toxicity. Firstly, we investigated Cu-toxic effects metabolomics, the levels free amino acids, NH4+-N, NO3--N, total nitrogen, soluble proteins, phenolics, lignin, reduced glutathione (GSH) and malondialdehyde, activities nitrogen-assimilatory enzymes in ‘Shatian’ pummelo (Citrus grandis) leaves. Then, a conjoint analysis physiology transcriptomics was performed. Herein, 59 upregulated [30 primary metabolites (PMs) 29...
Copper (Cu)-toxic effects on Citrus grandis growth and Cu uptake, as well gene expression physiological parameters in leaves were investigated. Using RNA-Seq, 715 upregulated 573 downregulated genes identified of C. seedlings exposed to Cu-toxicity (LCGSEC). altered the 52 related cell wall metabolism, thus impairing metabolism lowering leaf growth. photosynthetic electron transport-related genes, reducing CO2 assimilation. Some involved thermal energy dissipation, photorespiration, reactive...
We aimed to determine whether Neuropilin-1 (NRP1) promotes gastric cancer (GC) metastasis by inducing epithelial-mesenchymal transition (EMT), and clarify its regulatory mechanism.Using the data of GC patients in The Cancer Genome Atlas (TCGA) Gene Tissue Expression (GTEx) databases, combined with our medical center, effect NRP1 on prognosis were analyzed.Then, we investigated role potential mechanism.The level was up-regulated tissues associated poor patients.The expression closely related...
Healthy mammary gland is essential for milk performance in dairy cows. MicroRNAs (miRNAs) are the key molecules to regulate steady state of This study investigated potential role miR-29c bovine epithelial cells (bMECs). RNA sequencing (RNA-seq) was used measure transcriptome profile line (MAC-T) transfected with inhibitor or negative control (NC) inhibitor, and then differentially expressed genes (DEGs) were screened. The results showed that a total 42 up-regulated 27 down-regulated found...
Abstract Distant metastasis is currently the main factor affecting prognosis of nasopharyngeal carcinoma (NPC), and understanding mechanisms identifying reliable therapeutic targets are critical for improving achieving clinical translation. Macrophages, as important immune cells in tumor microenvironment (TME), have been shown to regulate metastasis. And extracellular vesicles (EVs) secreted by stromal play role intercellular communication microenvironment. However, NPC-EVs on macrophages...
Feature selection is a critical component of data mining and has garnered significant attention in recent years. However, feature methods based on information entropy often introduce complex mutual forms to measure features, leading increased redundancy potential errors. To address this issue, we propose FSCME, method combining Copula correlation ( <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Ccor</i> ) the maximum coefficient (MIC) by...
Mastitis is characterized by inflammatory damage to mammary gland tissue, which could decline milk production and quality significantly affect the economic benefits of ranching. MicroRNAs (miRNAs), such as miR-199a-3p, are novel therapeutic targets in inflammation, their regulation an effective strategy for inflammation control. Despite its importance humans animals, molecular mechanism bovine miR-199a-3p (bta-miR-199a-3p) dairy cow mastitis epithelial cell (bMEC) unclear. In our study, a...
Abstract Background Hypopharyngeal cancer (HPC) is associated with a poor prognosis and high recurrence rate. Immune escape one of the reasons for malignant tumors. Programmed cell death ligand 1 (PD-L1) programmed death-1 (PD-1) have been shown to play important roles in immune escape. However, role PD-1/PD-L1 HPC remains unclear. In this experiment, we investigated effect exosomes from patient serum on CD8+ T function expression and, thus, prognosis. We hope provide guidance identification...
Heat shock transcription factor (Hsf) exists widely in eukaryotes and responds to various abiotic stresses by regulating the expression of downstream factors, functional enzymes, molecular chaperones. In this study, TaHsfA2-13, a heat belonging A2 subclass, was cloned from wheat (Triticum aestivum) its function analyzed. TaHsfA2-13 encodes protein containing 368 amino acids has basic characteristics Hsfs. Multiple sequence alignment analysis showed that had highest similarity with...
In this study, we proposed a novel method called the graph capsule convolutional network (GCCN) to predict progression from mild cognitive impairment dementia and identify its pathogenesis. First, risk gene discovery component indirectly target genes with higher interactions others. These brain regions were collected as nodes construct heterogeneous pathogenic information association graphs. Second, capsules established by projecting into set of disentangled latent components. The...
Abstract Molting is a key solution to growth restriction in insects. The periodic synthesis and degradation of chitin, one the major components insect epidermis, necessary for growth. MicroRNA (miRNA) have been implicated molting regulation, yet their involvement interplay interaction between chitin pathway 20-hydroxyecdysone signaling remains poorly understood. In this study, soluble trehalase (Tre1) phosphoacetylglucosamine mutase (PAGM) were identified as targets conserved miR-8-3p...