A5051694922- Antibiotic Resistance in Bacteria
- Escherichia coli research studies
- Vibrio bacteria research studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotics Pharmacokinetics and Efficacy
- Infections and bacterial resistance
- Mycobacterium research and diagnosis
- Salmonella and Campylobacter epidemiology
- Acute Myocardial Infarction Research
- Enterobacteriaceae and Cronobacter Research
- Urinary Tract Infections Management
- Antimicrobial Peptides and Activities
- Cardiac, Anesthesia and Surgical Outcomes
- Bacteriophages and microbial interactions
- Sepsis Diagnosis and Treatment
- Bacterial biofilms and quorum sensing
- Antimicrobial agents and applications
Manouba University
2023
Tunis University
2016-2022
Tunis El Manar University
2016-2022
Faculté de médecine de Tunis
2016-2022
Hôpital Charles-Nicolle
2019
To describe clinical and molecular characteristics of an outbreak due to metallo-β-lactamases (MBLs) producing Klebsiella pneumoniae collected at Charles Nicolle Hospital Tunis analyze the impact outer membrane porin (OMP) loss on carbapenem resistance levels.Between 2010 2015, 178 carbapenem-resistant Enterobacteriaceae were isolated. Screening for MBL production was performed using combined disk diffusion method, with imipenem ethylene diamine tetraacetic acid (EDTA) as inhibitors....
Healthcare-associated infections due to cefotaxime-resistant (CTX-R) Enterobacteriaceae have become a major public health threat, especially in intensive care units (ICUs). Often acquired nosocomially, CTX-R can be introduced initially by patients at admission. This study aimed determine the prevalence and genetic characteristics of Enterobacteriaceae-intestinal carriage ICU patients, evaluate rate acquisition these organisms during hospitalization, explore some associated risk factors for...
This study was conducted to evaluate the rate of fecal carriage Gram-negative bacilli (GNB) resistant third-generation cephalosporins (third GC) in patients hospitalized intensive care unit (ICU) Charles Nicolle Hospital Tunis and identify enzymatic mechanisms involved. From February April 2014, rectal swabs were collected from all (n = 38) at admission once weekly thereafter acquisition. They cultured on desoxycholate-lactose-agar plates supplemented with cefotaxime (2 mg/L). The GNB third...
Since 2012, few reports on the molecular epidemiology of Pseudomonas aeruginosa were reported in Tunisia.This study aimed to evaluate carbapenem-resistance determinants and compare carbapenemase-phenotypic detection methods multidrug-resistant P. isolates.During a period four years (2014 2017), all imipenem-ceftazidime-resistant isolates retrospectively selected at microbial laboratory Charles Nicolle hospital Tunis. These examined by modified Hodge test, carbapenem inactivation method...
Septic shock is a leading cause of mortality in intensive care units (ICUs).Despite recent advances the management septic shock, rates have remained remarkably high, ranging from 30 to 50%. 1 Myocardial dysfunction one mechanisms involved pathophysiology shock.Septic myocardial usually defined as global (systolic and diastolic) but reversible biventricular dysfunction. 2An incidence 20 60% has been reported first 3 days after onset shock. 3Ventricular function generally returns normal within...
Actually, no data on the prevalence of plasmid colistin resistance in Tunisia are available among clinical bacteria.This study aimed to investigate current epidemiology and spread mcr gene Gram-negative bacteria (GNB) isolated from six Tunisian university hospitals.A total 836 GNB strains were inoculated COL-R agar plates with selective screening for isolation resistant colistin. For selected isolates, genes, beta-lactamases associated-resistance genes molecular characterisation screened by...
Antimicrobial resistance is one of the most serious threats to human and animal health. Evidence suggests that overuse antimicrobial agents in production has led emergence dissemination multidrug-resistant isolates. The objective this study was assess rate extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli calf feces characterize their genes for antibiotics like beta-lactams colistin, but also determine virulence genes. Fecal samples were collected from 100 diarrheic calves...
Purpose of the Study: This study was conducted to detect and characterize genes encoding extended spectrum β-lactamases associated (carbapenemases Ambler Class C β-lactamases).Patients Methods: In 2011, out 65 non-duplicative Klebsiellapneumoniae collected from blood culture at Charles Nicolle hospital Tunisia, 36 were resistant 3rd generation cephalosporin.Results: All strains showed a double disk synergy test positive. They mainly isolated in intensive care unit (31%). frequently most...