A5054453202- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Alzheimer's disease research and treatments
- Bioactive Compounds and Antitumor Agents
- Advanced Polymer Synthesis and Characterization
- Lipid Membrane Structure and Behavior
- Berberine and alkaloids research
- Biochemical effects in animals
- Advanced Glycation End Products research
- Ferroptosis and cancer prognosis
- Cholinesterase and Neurodegenerative Diseases
- Metabolism and Genetic Disorders
- Free Radicals and Antioxidants
- Photopolymerization techniques and applications
- Coenzyme Q10 studies and effects
- RNA modifications and cancer
- Light effects on plants
- Polymer Nanocomposite Synthesis and Irradiation
- Lipid metabolism and biosynthesis
- Photoreceptor and optogenetics research
- Biochemical and Molecular Research
- Photochromic and Fluorescence Chemistry
- Photosynthetic Processes and Mechanisms
Lomonosov Moscow State University
2013-2024
H.Buniatian Institute of Biochemistry
2015
Physico-Technical Institute
2011
A.V. Topchiev Institute of Petrochemical Synthesis
1977
Ferroptosis induced by erastin (an inhibitor of cystine transport) and butionine sulfoximine glutathione biosynthesis) was prevented the mitochondria-targeted antioxidants SkQ1 MitoTEMPO. These effects correlate with prevention mitochondrial lipid peroxidation, which precedes cell death. Methylene blue, a redox agent that inhibits production reactive oxygen species (ROS) in complex I electron transport chain, also ferroptosis peroxidation. Activation ROS rotenone presence ferrous iron...
A limited decrease in mitochondrial membrane potential can be beneficial for cells, especially under some pathological conditions, suggesting that mild uncouplers (protonophores) causing such an effect are promising candidates therapeutic uses. The great majority of protonophores weak acids capable permeating across membranes their neutral and anionic forms. In the present study, protonophorous activity a series derivatives cationic rhodamine 19, including dodecylrhodamine (C(12)R1) its...
Lipid peroxidation plays an important role in various pathologies and aging, at least partially mediated by ferroptosis. The of mitochondrial lipid during ferroptosis remains poorly understood. We show that supplementation exogenous iron the form ferric ammonium citrate submillimolar doses induces production reactive oxygen species (ROS) mitochondria precede H9c2 cardiomyocytes. mitochondria-targeted antioxidant SkQ1 redox mediator methylene blue, which inhibits ROS complex I electron...
Possible involvement of the ATP/ADP antiporter and uncoupling protein (UCP) in thermoregulatory oxidative phosphorylation heart muscle has been studied. To this end, effects carboxyatractylate (cAtr) GDP, specific inhibitors UCP, on membrane potential oligomycin-treated mitochondria from cold-exposed (6 degrees C, 48 h) control rats have measured. It is found that cAtr increases level both non-exposed groups, effect being strongly enhanced by cooling. As for it effective only rats. In these...
Receptor for advanced glycation end products (RAGE) is involved in the pathogenesis of Alzheimer's disease. We have previously revealed that RAGE fragment sequence (60-76) and its shortened analogues (60-70) (60-65) under intranasal insertion were able to restore memory improve morphological biochemical state neurons brain bulbectomized mice developing major AD features. In current study, we investigated ability peptide five bind beta-amyloid (Аβ) 1-40 an immunofluorescence test show all...