A5040522243- Trace Elements in Health
- Vitamin C and Antioxidants Research
- Bone Metabolism and Diseases
- Iron Metabolism and Disorders
- Folate and B Vitamins Research
- Bone health and treatments
- Polyomavirus and related diseases
- Bacteriophages and microbial interactions
- Redox biology and oxidative stress
- Cell death mechanisms and regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Glutathione Transferases and Polymorphisms
- Full-Duplex Wireless Communications
- Glycosylation and Glycoproteins Research
- Nanoparticles: synthesis and applications
- Energy Harvesting in Wireless Networks
- Bacterial Genetics and Biotechnology
- Metal-Catalyzed Oxygenation Mechanisms
- Heavy Metal Exposure and Toxicity
- Plant Virus Research Studies
- Hemoglobinopathies and Related Disorders
- Sugarcane Cultivation and Processing
- Marine Sponges and Natural Products
- Cancer-related Molecular Pathways
- Biofuel production and bioconversion
Southern California Institute for Research and Education
2021-2025
Long Beach Medical Center
2025
VA Long Beach Healthcare System
2021-2024
International Centre for Genetic Engineering and Biotechnology
2011-2023
Jamia Hamdard
2016
Department of Biotechnology
2016
Increased intracellular iron spurs mitochondrial biogenesis and respiration to satisfy high-energy demand during osteoclast differentiation bone-resorbing activities. Transferrin receptor 1 (Tfr1) mediates cellular uptake through endocytosis of iron-loaded transferrin, its expression increases differentiation. Nonetheless, the precise functions Tfr1 Tfr1-mediated in biology skeletal homeostasis remain incompletely understood. To investigate role lineage cells vivo vitro, we crossed Tfrc...
Abstract Mutations in PLEKHM1 cause osteopetrosis humans and rats. The germline osteoclast conditional deletions of Plekhm1 gene mice lead to defective bone resorption increased trabecular mass without overt abnormalities other organs. As an adaptor protein, pleckstrin homology RUN domain containing M1 (PLEKHM1) interacts with the key lysosome regulator small GTPase RAB7 via its C-terminal RUBICON homologous (RH) domain. In this study, we have conducted a structural-functional study RH...
There are three FAM98 family proteins (FAM98A/B/C) in humans and mice. Their physiological functions remain largely unknown. We have previously reported that Fam98a interacts with Plekhm1 murine osteoclasts lysosome trafficking/secretion bone resorption vitro. In this study, we found all Fam98 genes were expressed precursor mature osteoclasts. While the knockdown of Fam98c by a specific short-hairpin RNA (shRNA) osteoclast precursors attenuated osteoclastogenesis, depletion Fam98b an shRNA...
Merkel cell carcinoma (MCC), a rare but aggressive skin cancer, remains challenge in the era of precision medicine. Immune checkpoint inhibitors (ICIs), only approved therapy for advanced MCC, are impeded by high primary and acquired resistance. Hence, we dissect transcriptomic heterogeneity at single-cell resolution panel patient tumors, revealing phenotypic plasticity subset treatment-naive MCC. The tumor cells "mesenchymal-like" state endowed with an inflamed phenotype that portends...
Merkel cell carcinoma (MCC) is an often-lethal skin cancer with increasing incidence and limited treatment options. Although immune checkpoint inhibitors (ICI) have become the standard of care in advanced MCC, 50% all MCC patients are ineligible for ICIs, amongst those treated, many develop resistance. There no therapeutic alternative these patients, highlighting urgent clinical need strategies. Using patient-derived genetic insights data generated our lab, we identified aurora kinase as a...
Cytoskeleton organization and lysosome secretion play an essential role in osteoclastogenesis bone resorption. The cytoplasmic dynein is a molecular motor complex that regulates microtubule dynamics transportation of cargos/organelles, including lysosomes along the microtubules. LIS1, NDE1, NDEL1 belong to evolutionary conserved pathway functions. Disruption deletion LIS1 osteoclast precursors arrest osteoclastogenesis. Nonetheless, NDE1 biology remains elusive. In this study, we found...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on Marine Chemicals, Part IV. Isolation of Cholesterol Derivatives from the Sponge Spirastrella inconstansB. Das and K. V. N. S. SrinivasCite this: J. Nat. Prod. 1992, 55, 9, 1310–1312Publication Date (Print):September 1, 1992Publication History Published online1 July 2004Published inissue 1 September 1992https://doi.org/10.1021/np50087a021RIGHTS & PERMISSIONSArticle Views166Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are...
There are three FAM98 family proteins (FAM98A/B/C) in human and mice. Their physiological functions remain largely unknown. We have previously reported that Fam98a interacts with Plekhm1 murine osteoclasts lysosome trafficking/secretion bone resorption vitro. In this study, we found all Fam98 genes were expressed precursor mature osteoclasts. While knockdown of Fam98c by a specific short-hairpin RNA (shRNA) osteoclast precursors attenuated osteoclastogenesis, depletion Fam98b shRNA...
Abstract Increased intracellular iron spurs mitochondrial biogenesis and respiration to satisfy high-energy demand during osteoclast differentiation bone-resorbing activities. Transferrin receptor 1 (TFR1) mediates cellular uptake through endocytosis of iron-loaded transferrin its expression increases differentiation. Nonetheless, the precise functions TFR1 TFR1-mediated in biology skeletal homeostasis remain incompletely understood. To investigate role lineage cells, we conditionally...
Abstract Glutaredoxins (Grxs) are single-domain redox enzymes of the thioredoxin superfamily, and primarily function as glutathione (GSH) dependent disulphide reductases. Whereas, E. coli Glutaredoxin 2 ( Ec Grx2) encoded by grxB has two conserved GST-fold domains, it still lacks a classical Grx-like functions. In this study, we show for first time, that Grx2 exists in both soluble membrane integrated forms. The form associates with previously unidentified GSH dehydroascrobate (DHA)...
Abstract Ascorbate, a primary antioxidant, gets readily oxidized to dehydroascorbate (DHA). Hence, recycling by reductase (DHAR) enzymes is vital for protection from cellular oxidative stress in eukaryotes. However, detailed kinetic analysis of plant DHARs and their human orthologs; chloride intracellular channels ( Hs CLICs) lacking. We demonstrate that DHAR adapted pearl millet Pennisetum glaucum Pg DHAR) shows the highest turnover rate whereas CLIC1, 3, 4 reduce DHA, albeit at lower...