A5027583416- Heart Failure Treatment and Management
- Cardiovascular and exercise physiology
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Chronic Kidney Disease and Diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Hormonal Regulation and Hypertension
- Exercise and Physiological Responses
- Muscle activation and electromyography studies
- Advanced Glycation End Products research
- Antioxidant Activity and Oxidative Stress
- Pain Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- Muscle metabolism and nutrition
- Cardiovascular Health and Risk Factors
- Renal and Vascular Pathologies
- Muscle Physiology and Disorders
- Sports Performance and Training
- Hemodynamic Monitoring and Therapy
- Physical Activity and Health
- Cardiac Fibrosis and Remodeling
University of Minnesota
2005-2022
University of Minnesota Medical Center
2005-2019
Wayne State University
2018
Vanderbilt University
2005-2017
American Heart Association
2017
National Institutes of Health
2017
DuPont (United States)
2017
University of Ontario Institute of Technology
2017
Dupont Hospital
2017
Vanderbilt University Medical Center
2011-2015
GASKILL, S. E., B. C. RUBY, A. J. WALKER, O. SANCHEZ, R. SERFASS, and LEON. Validity reliability of combining three methods to determine ventilatory threshold. Med. Sci. Sports Exerc., Vol. 33, No. 11, 2001, pp. 1841–1848. Purpose: This research was undertaken validate a combination methodologies threshold (VT). Methods: Three were used individually then combined VT as follows: 1) equivalencies, 2) excess CO2 production, 3) modified V-slope method. groups participants—endurance athletes (N =...
Oxidative stress, inflammation and endothelial dysfunction are interrelated factors in the etiology of cardiovascular disease, but their linkage to type 2 diabetes is less clear. We examined association these biomarkers with incident (T2D). Analysis 2339 participants community-based coronary artery risk development young adults (CARDIA) study. Participants (age 40.1 ± 3.6 years, 44 % Black, 58 women) were free diabetes, followed 10 years. Cox regression was used estimate hazard ratios (HRs)...
Abstract BACKGROUND GlycA is a biomarker that reflects integrated concentrations and glycosylation states of several acute-phase proteins. We studied the association inflammatory biomarkers with future death disease. METHODS A total 6523 men women in Multi-Ethnic Study Atherosclerosis who were free overt cardiovascular disease (CVD) generally good health had baseline blood sample taken. assayed high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), d-dimer. spectral deconvolution...
OBJECTIVES: To investigate the validity and reliability of surface electromyography (EMG) as a new non-invasive determinant metabolic response to incremental exercise in elite cyclists. The relation between EMG activity other more conventional methods for analysing aerobic-anaerobic transition such blood lactate measurements (lactate threshold (LT) onset accumulation (OBLA)) ventilatory parameters (ventilatory thresholds 1 2 (VT1 VT2)) was studied. METHODS: Twenty eight road cyclists (age 24...
Nonenzymatic modification of proteins in hyperglycemia is a major mechanism causing diabetic complications. These modifications can have pathogenic consequences when they target active site residues, thus affecting protein function. In the present study, we examined role glucose autoxidation functional damage using lysozyme and RGD-α3NC1 domain collagen IV as model vitro. We demonstrated that induced inhibition activity well NC1 binding to αVβ3 integrin receptor via critical arginine...
In diabetes, toxic oxidative pathways are triggered by persistent hyperglycemia and contribute to diabetes complications. A major proposed pathogenic mechanism is the accumulation of protein modifications that called advanced glycation end products. However, other nonenzymatic post-translational may also damage in diabetes. We demonstrate hypohalous acid–derived renal tissues extracellular matrix (ECM) proteins significantly elevated experimental diabetic nephropathy. Moreover, ECM shows...
Incidence of postdonation hypertension, risk factors associated with its development, and impact type treatment received on renal outcomes were determined in 3700 kidney donors. Using Cox proportional hazard model, adjusted ratios (HRs) for cardiovascular disease (CVD); estimated glomerular filtration rate (eGFR) <60, <45, <30 mL/min/1.73m2 ; end stage (ESRD); death hypertensive donors determined. After a mean (standard deviation [SD]) 16.6 (11.9) years follow-up, 1126 (26.8%) developed...
Excess deposition of fat within and around vital organs nonadipose tissues is hypothesized to contribute cardiovascular disease (CVD) risk. We evaluated the association abdominal intermuscular adipose tissue (IMAT) volume with coronary artery calcification in CARDIA study (Coronary Artery Risk Development Young Adults) participants.
High-density lipoprotein (HDL) particles have properties beyond reverse cholesterol transport. We hypothesized that their protection extends to inflammation-related disease. The predictive value of HDL particle subclasses and inflammatory markers was studied for noncardiovascular, noncancer chronic death hospitalization, incident cardiovascular disease (CVD).A multiethnic, multicenter, prospective observational study conducted in 6475 men women (aged 45 84 years) free known CVD at baseline...
Abstract Blood oxygenation level dependent (BOLD) contrast in skeletal may reflect the contributions of both intravascular and extravascular relaxation effects. The purpose this study was to determine significance BOLD effect muscle at 3 T. In experiments, R 2 * measured before during arterial occlusion under following conditions: ( 1 ) leg extended rotated (to vary capillary orientation with respect amplitude static field) blood's signal nulled using a multiecho vascular space occupancy...
Higher circulating concentrations of cellular adhesion molecules (CAMs) can be used as markers endothelial dysfunction. Given that the brain is highly vascularized, we assessed whether function associated with cognitive performance.
In the general population, obesity is associated with an increased risk of developing hypertension (HTN), type 2 diabetes mellitus (DM), and end-stage renal disease (ESRD). Therefore, most transplant centers have a body mass index (BMI) threshold for accepting living kidney donors. But there been no studies postdonation weight gain trends any risks. We tracked serial BMIs in 940 donors median (IQ range) follow-up 22.3 (15.4-35.8) years. studied impact model adjusted family history HTN or DM....
The purpose of this study was to determine whether there are differences in postisometric contraction blood volume and oxygenation responses among groups type 2 diabetes mellitus (T2DM), obese, lean individuals detectable using MRI. Eight T2DM patients were individually matched by age, sex, race non-T2DM with similar body mass index (obese) subjects. Functional MRI performed a dual-gradient-recalled echo, echo-planar imaging sequence repetition time 1 s at two echo times (TE = 6 46 ms). Data...
Longitudinal associations between the aminoterminal pro-B-type natriuretic peptide (NT-proBNP) and incident hypertension are lacking.We tested baseline NT-proBNP (bNT-proBNP) change in (ΔNT-proBNP) (visit 3 - bNT-proBNP, 3.2 years apart) with (SBP ≥ 140 and/or DBP ≥90 mmHg or taking antihypertensive medications). Incident was evaluated 5596 individuals Multi-Ethnic Study of Atherosclerosis without at (53% women, age range 45-84 overt cardiovascular disease) follow-up for 9.5 a subgroup...
The purpose of this study was to characterize the contractile properties individual skinned muscle fibers from insulin-treated streptozotocin-induced diabetic rats after an endurance exercise training program. We hypothesized that single-fiber function would decrease in sedentary and preserve function. In study, 28 were assigned either a nondiabetic sedentary, exercise, or group. Rats groups received subcutaneous intermediate-lasting insulin daily. exercise-trained ran on treadmill at...
The effects of gestation, lactation and season on plasma thyroxine kinetics in the mare were studied following a single injection 131I-thyroxine. labeled was recovered from by trichloroacetic acid (TCA), LH-20 column purification methods. Plasma concentrations determined protein competitive binding technique. No significant difference observed for mean half-life values obtained TCA Thyroxine unaffected (winter, 47.2 hr. vs. summer, 54.4 hr.), pregnancy (non-pregnant, early pregnancy, 58.6...
Sustained remodeling of extracellular matrix can compromise organs and tissues. Procollagen type III N-terminal propeptide (PIIINP) collagen I carboxy-terminal telopeptide (ICTP) reflect synthesis degradation. We studied their predictive value for future death disease.A total 3068 men women in the Multi-Ethnic Study Atherosclerosis who were free cardiovascular disease (CVD) generally good health had a baseline blood sample taken ICTP PIIINP. Median follow-up was 13.0 years. Among 4 primary...