The BZLF1 protein of Epstein-Barr virus (EBV) is a key immediate-early which has been shown to disrupt latency in EBV-infected B cells. We have generated monoclonal antibody, BZ1, reacts immunohistology, immunoblotting, and immunoprecipitation recognizes both the active, dimeric form inactive, monomeric protein. Biopsies oral hairy leukoplakia, an AIDS-associated lesion characterized by high-level EBV replication, were examined immunohistochemistry using BZ1 antibody. A...

Epstein-Barr virus (EBV) infects both B lymphocytes and oropharyngeal epithelium, it has been argued that the true reservoir of persistence in vivo is self-renewing basal epithelial compartment. The identification oral hairy leukoplakia (HL) AIDS patients as a clinically apparent focus EBV replication lingual epithelium therefore provides means studying EBV-epithelial cell interaction situ. Replicative DNA productive cycle antigens are restricted to upper, more differentiated layers HL, here...

ObjectiveTo evaluate the cascade of HIV care in Oman 2018 and longitudinal change each step from 2015 to 2018.MethodsPopulation-based data on all diagnosed people living with reported National AIDS Programme 1984–2018 were used.ResultsAs December 31, 2018, estimated number was 3030; 1532 (50.6%) aware their infection. Of patients, 95.9% linked care, 85.8% retained 84.3% ART. The proportions patients viral suppression out HIV, persons, those ART 37.3%, 73.7%, 87.5%, respectively. proportion...

The aim of this study was to determine the proportions and predictors late presentation (LP) advanced HIV disease (AD) in Oman. LP AD were defined as presenting with a baseline CD4 count < 350 200 cells/mm3, respectively.We conducted retrospective database analysis National Surveillance System identify Omani people (≥ 13 years old) who diagnosed period between January 2000 December 2019 had documented cell count. We calculated rates trend over time AD. A logistic regression carried out AD.A...

OBJECTIVES--To investigate the presentation of HIV infection and AIDS amongst Africans diagnosed with living in London. METHODS--Identification all cases African origin attending four specialist centres South London--Guy9s, King9s, St George9s Thomas9 Hospitals--up to March 1994, by retrospective review case notes positive patients. RESULTS--Of 86 patients (53 women, 33 men) studied, 59 (69%) were from Uganda. The most frequent AIDS-defining diagnoses were: Pneumocystis carinii pneumonia...

A variant form of splicing RNA crossing the Epstein-Barr virus (EBV) BZLF1 gene was observed in late productive cycle EBV. This splice omits middle exon and joins outer two exons frame, but shortened protein (Z delta) could not be detected natural EBV infections.

A number of surveys highlight a shortage dentists in the UK. There is also evidence discrimination against those with HIV reported within dental profession and service users. We decided to assess extent this problem our outpatients by conducting cross-sectional survey, asking them complete questionnaire exploring issues related care access, using clients attending routine genitourinary (GU) medicine outpatient clinic as controls. total 241 completed whom 51 (21%) were patients....

We used population-based data on all diagnosed people living with Human Immunodeficiency (HIV) reported to the National AIDS Programme in 1984-2018 describe HIV epidemiology Oman.A total of 3060 Omanis were from 1984 2018.The proportions new infections attributed sexual contact accounted for 56.3% (376/668) 1984-1996 compared 80.7% (630/780) 2013-2018.Of 1417 patients a documented CD4 count at entry care, 45.3% had baseline <200 cells/mm 3 .Compared heterosexuals, homosexuals higher rates...

Previous studies have highlighted disparities in care and outcomes HIV-positive prisoners compared to individuals the population. We audited clinical of accessing 2011. Public Health England were notified 161 with HIV time period studied. Audit proformas sent clinics reporting genitourinary medicine clinic activity dataset Thirty-two responded. Data for 151 reported by 12 clinics, other not any prisoners. Outcomes a previous audit, British Association (BHIVA) National AIDS Trust guidelines....

Gynaecomastia arising in the context of antiretroviral therapy for HIV infection presents a number challenges diagnosis and management. We describe thirty year old gay man with rapidly developing breast enlargement who was successfully treated anti-oestrogen tamoxifen.

Gonococcal eye infection in adults is an uncommon cause of blindness, where prompt diagnosis and effective treatment are essential the prevention ophthalmic morbidity. We present a case report detailing management complications encountered this condition patient coinfected with human immunodeficiency virus (HIV).

In January 2016, the National AIDS Programme (NAP) in Oman introduced a package of interventions, including capacity building for service providers, to improve quality HIV services.To report impact these interventions on rate vertical transmission period from 2016 December 2019. We also describe virological and obstetric outcomes HIV-infected pregnant women.This was medical record review 94 HIV-positive women (median age 32 years; interquartile range 25-34 years) reported NAP 2016-2019.There...

Resistance of Neisseria gonorrhoeae (GC) to azithromycin is increasing. The dose used for treating uncomplicated genital chlamydia may be subtherapeutic GC and contribute gonococcal resistance. National Chlamydia Screening Programme (NCSP) does not routinely screen but advises further testing clients with symptoms. This will miss asymptomatic cases. We conducted a case-note review 100 women aged 16–24 years diagnosed co-infected chlamydia, who attended London genitourinary clinic from 1...

A cohort of homosexual men at risk for human immunodeficiency virus (HIV) infection were studied prospectively over a 7-year period (1982/88) to assess trends in sexual behaviour and amyl nitrite intake. During the period, there dramatic declines proportion HIV seropositive seronegative subjects reporting multiple casual partners anal intercourse, unprotected intercourse recreational use nitrite. Reported rates orogenital remained same during whilst total number seroconversions fell from 17...

The commissioning of health services for all prisoners in publicly run prisons England was transferred to local Primary Care Trusts April 2006, pledging provide an equivalent standard care as that the community. We reviewed our experience providing a specialist in-reach HIV service by performing retrospective case notes review HIV-positive who accessed from prison genitourinary medicine three London prisons. A total 112 were seen health-care between 2004 and 2006. This is first study look at...

We conducted a cross-sectional analysis to determine HIV virologic failure and its associated factors among Omani people living with who are on ART for &gt; 6 months. Patients (n = 1427) were identified from central national surveillance dataset. Two-thirds (67%) of patients male, the median age was 39 years (IQR, 32-48 years). Out 1427 patients, 14.4% had (HIV viral load [VL] ≥ 200 copies/ml). The multivariate showed that aged 25-49 (adjusted odds ratio [aOR]: 1.76, 95% CI: 1.01-3.08)...

In 2008, guidelines aimed at reducing undiagnosed HIV infection were published, recommending normalization of testing. Local initiatives carried out in south-west London including an extensive primary care education programme. This study to establish the impact these on diagnoses. Data all new diagnoses referred our centre collected and analysed from patient records. A total 394 patients newly diagnosed with 2007 2011. Diagnosis other non-sexual health (SH) settings increased by 184% during...

Three hundred and fourteen homosexual/bisexual men at risk for human immunodeficiency virus (HIV) infection (170 seroprevalent HIV-positive, 144 seronegative) were prospectively studied over 8 years to assess rates of HIV disease progression, in conjunction with cellular serological markers. In HIV-positive subjects, CD4+ lymphocyte counts rose strikingly during the period surrounding seroconversion, then fell progressively intervening a mean level 300 cells/mm 3 when AIDS developed. Changes...