Abstract T and B lymphocytes have been implicated in the pathogenesis of renal ischemia reperfusion injury (IRI). The trafficking into kidneys during IRI has postulated to underlie this effect, but not rigorously studied. We therefore characterized lymphocyte populations infiltrating mouse 3 24 h after IRI. Immunohistochemistry flow cytometry staining kidney showed increased CD3+ cells CD19+ both sham-operated mice In mice, infiltration NK1.1+ CD4+NK1.1+ compared with normal was observed...

Turmeric (Curcuma longa) is a rhizomatous herbaceous perennial plant of the ginger family which has been used to treat biliary disorders, anorexia, cough, rheumatism, cancer, sinusitis, hepatic hyperglycemia, obesity, and diabetes in both Ayurvedic Traditional Chinese Medicine. Suggested mechanisms action include modulation signal transduction cascades effects on gene expression, however they remain be elucidated. In this study, expression some proteins responsible for transcription factors,...

Nitrosative and oxidative stress play a key role in obesity diabetes-related mitochondrial dysfunction. The objective was to investigate the effect of curcumin treatment on state 3 4 oxygen consumption, nitric oxide (NO) synthesis, ATPase activity lipid oxidation mitochondria isolated from liver kidneys diabetic db/db mice. Hyperglycaemia increased consumption decreased NO synthesis mice relative control In kidney mitochondria, hyperglycaemia thiobarbituric acid-reactive substances (TBARS)...

Abstract Healthy liver, intestine, lung, and skin harbor resident lymphocytes with conventional unconventional phenotypes. Lymphocytes also have been detected in healthy mice kidneys; however, these cells not well studied largely overlooked. To better characterize the intra-renal lymphocytes, we extensively perfused C57BL/6J PBS then isolated mononuclear for flow cytometry analysis. We observed T cells, B NK normal kidneys after extensive perfusion. Approximately 50% of kidney expressed...

We evaluated the effects of curcumin treatment on protein oxidation (PO), lipid peroxidation (LP) and brain-derived neurotrophic factor (BDNF) levels in hippocampus frontal cortex (FC) diabetic db/db mice (DM) sera obese humans. Thus, DM were treated daily with 50 mg/kg during an 8-week period. Obese human 500 750 mg that was administered orally for 12 weeks; BDNF, PO LP determined at weeks 0, 2, 6 treatment. BDNF decreased FC as compared untreated wild-type mice. Curcumin improved or...

Type 2 diabetes mellitus (T2DM) is characterized by chronic inflammation, in which different types of immune cells participate, such as TH17 and Treg cells. The aim this study was to determine the relationship between Th17 patients with times T2DM progression.Nineteen control subjects 40 were included. classified into two groups: first group consisted twenty less than10 years disease progression (T2DM < 10), second included 20 a 10 or more ≥ 10). Additionally, an analysis performed according...

The COVID-19 pandemic showed an impact mainly on the health of people and economy households. levels food security in world’s households, especially Mexico, have decreased. When do not security, their is compromised they financial problems; other hand, environmental deterioration has a link with security. purpose this review to analysis current situation Mexico economy, main lessons learned these areas proposals integrating public policies. A was carried out databases (MEDLINE, Embase,...

Abstract Salmonella species invade the host via intestinal epithelium. Hence, intraepithelial lymphocytes (iIELs) are potentially first element of immune system to encounter during infection. In this study, we demonstrate, in a mouse model, expansion CD8αβ+CD94−TCRγδ+ T cell subset within iIEL population response oral infection with virulent or avirulent Salmonella. This can be detected 3 days following infection, represents up 15% TCRγδ+ iIELs, and is dependent on MHC class Ib molecule T23...

Recently, a direct correlation with telomere length, proliferative potential and telomerase activity has been found in the process of aging peripheral blood cells. The objective study was to evaluate length mononuclear cells (PBMCs) after stimulation Concanavalin A (ConA) young adults compared older adults. Blood samples were obtained from 20 healthy males (20–25 years old) (group Y) (60–65 O). We PBMC proliferation before ConA. DNA isolated separated culture ConA for telomeric measurement...

Escherichia coli (E.coli) is a widely distributed microorganism in nature and normally colonize the human gastrointestinal tract.E. strains are part of normal gut microbiota.In recent years, some E. producing genotoxin colibactin have been associated with development progression colon cancer.However, role their toxins carcinogenesis not entirely clear.Thus, proteins secreted by bacteria may trigger promote tumor development.In this paper, we focus on reviewing produced coli, which...

A device's instrumentation for magnetic stimulation on human lymphocytes is presented. This a new procedure to stimulate growing cells with ferrofluid in vortices of field. The was provided at five different frequencies, from 100 2500 Hz and intensities 1.13 4.13 mT. To improve the effects, paramagnetic added cell culture medium. results suggest that frequency changes field variation produce an important increase number proliferating as well cellular viability. modality could trigger...

Type 2 diabetes mellitus is characterized by hyperglycemia and insulin resistance. Liver a key organ for the maintenance of systemic glucose homeostasis in mammals, including humans mice. Under many nutritional conditions liver maintains nearly constant blood glucose. We analyzed protein profile from ten-week old diabetic obese db/db mice through twodimensional electrophoresis (2DE) identity differentially expressed proteins was determined using matrix-assisted laser desorption/ionization...

Although it has been shown that gammadelta T lymphocytes are able to react with different cell-associated or soluble antigens, the immune repertoire of these cells appears be skewed recognition mycobacterial antigens. We have studied number and reactivity towards several antigens in patients tuberculosis leprosy, as well their healthy contacts control individuals. found an increased Vdelta2+ (PPD+ lepromin+) tuberculoid leprosy patients. The from lepromatous showed a decreased response all...

La diabetes mellitus (DM) es una enfermedad metabólica que frecuentemente se presenta en perros, caracteriza por niveles elevados de glucosa plasmática. En la actualidad, no existe ninguna clasificación los distintos tipos este padecimiento perros. humanos, puede clasificarse como: DM tipo I, II y asociada a gestación. perros utiliza misma pero hay cuadros clínicos asociados al diestro pancreatitis. el 50% I resto agrupa entre otros. Los principales signos presentan diabéticos son: poliuria,...

The aim of the present study was to describe presence co-infection by

La diabetes mellitus (DM) es una enfermedad metabólica crónica y compleja caracterizada por niveles elevados de glucosa en sangre (hiperglucemia). Además los síntomas clásicos como la poliuria, polidipsia, pérdida peso visión borrosa; cronicidad hiperglucemia tiene potenciales riesgos a largo plazo. Recientes investigaciones han demostrado que DM afecta significativamente salud ósea alterando densidad mineral (DMO), predisponiendo al desarrollo osteoporosis mayor riesgo fracturas. En el...