A5102785918- Endometrial and Cervical Cancer Treatments
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- MRI in cancer diagnosis
- Glioma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Radiation Therapy and Dosimetry
- Brain Metastases and Treatment
- Cervical Cancer and HPV Research
- Breast Implant and Reconstruction
- Lung Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Management of metastatic bone disease
- Medical Imaging Techniques and Applications
- Colorectal Cancer Surgical Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Traffic Prediction and Management Techniques
- Gastric Cancer Management and Outcomes
- Tannin, Tannase and Anticancer Activities
- Sarcoma Diagnosis and Treatment
- Total Knee Arthroplasty Outcomes
- Reconstructive Surgery and Microvascular Techniques
- Traditional Chinese Medicine Analysis
- Time Series Analysis and Forecasting
Kyungpook National University
2013-2024
Kyungpook National University Hospital
2013-2022
Dong-Eui University
2019
Keimyung University
2018-2019
Kyungpook National University Medical Center
2015-2017
Creative Research Enterprises (United States)
2016
Samsung Medical Center
2013
Sungkyunkwan University
2013
Concurrent chemoradiotherapy (CRT) is the standard treatment for locally advanced cervical cancer (LACC), but its responsiveness varies among patients. A reliable tool predicting CRT responses necessary personalized treatment. In this study, we constructed prediction models using handcrafted radiomics (HCR) and deep learning (DLR) based on pretreatment MRI data to predict response in LACC. Furthermore, investigated potential improvement performance by incorporating clinical factors. total of...
Abstract Background Radiomics is a promising field in oncology imaging. However, the implementation of radiomics clinically has been limited because its robustness remains unclear. Previous CT and PET studies suggested that radiomic features were sensitive to variations pixel size slice thickness images. The purpose this study was assess magnetic resonance (MR) resampling interpolation patients with cervical cancer. Methods This retrospective included 254 pathological diagnosis cancer stages...
To determine the incidence, risk factors, and clinical characteristics of pelvic insufficiency fracture (PIF) in patients with cervical cancer.Between July 2004 August 2009, 235 non-metastatic cancer were treated definitive chemoradiation or postoperative radiotherapy. Among patients, 117 (49.8%) underwent first positron emission tomography/computed tomography (PET/CT) within 1 year after The median radiation dose was 55 Gy (range, 45 to 60 Gy). Medical charts imaging studies, including...
This study aimed to build a comprehensive deep-learning model for the prediction of radiation pneumonitis using chest computed tomography (CT), clinical, dosimetric, and laboratory data.
Some patients with glioblastoma show a worsening presentation in imaging after concurrent chemoradiation, even when they receive gross total resection. Previously, we showed the feasibility of machine learning model to predict pseudoprogression (PsPD) versus progressive disease (PD) patients. The previous was based on dataset from two institutions (termed as Seoul National University Hospital (SNUH) dataset, N = 78). To test this larger collected cases multiple that raised problem PsPD vs....
The purpose of the current in silico planning study is to compare radiation doses whole-breast irradiation (WBI) and plus regional lymph node (WBI+RNI) administered nodes (RLN) pN1 breast cancer. Twenty-four participating institutions were asked create plans WBI WBI+RNI for two dummy cases. To target coverage between participants, an isodose line equal 90% prescribed dose was converted contour (contour90% iso). relative nodal (RND) obtained using ratio RLN dose. Fleiss’s kappa values which...
Abstract Background Current chemoradiation regimens for locally advanced cervical cancer are fairly uniform despite a profound diversity of treatment response and recurrence patterns. The wide range responses prognoses to standardized concurrent highlights the need reliable tool predict outcomes. We investigated pretreatment magnetic resonance (MR) imaging features primary tumor involved lymph node predicting clinical outcome in patients. Methods included 93 node-positive patients treated...
Objective This study investigated the metabolic parameters of primary tumors and regional lymph nodes, as measured by pre-treatment F-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) to compare prognostic value for prediction tumor recurrence. also identified most powerful parameter in patients with locally advanced cervical cancer treated concurrent chemoradiotherapy. Methods Fifty-six who were diagnosed pelvic and/or paraaortic node metastasis...
Cordycepin, a derivative of nucleoside adenosine, is one the active ingredients extracted from fungi genus Cordyceps, which have been used for traditional herbal remedies. In this study, we examined effect cordycepin on proliferation and apoptosis human bladder cancer T24 cells its mechanism action. Cordycepin treatment significantly reduced cell survival rate in concentration-dependent manner, was associated with induction apoptosis. activated caspase-8 -9, are involved initiation extrinsic...
We evaluated the clinical implications of pre- and post-treatment hematological parameters as prognostic factors in patients with locally advanced cervical cancer (LACC) who received definitive concurrent chemoradiotherapy (CCRT).We retrospectively analyzed 125 LACC (FIGO stage IIB to IIIB) CCRT. Clinical parameters, including neutrophil-to-lymphocyte ratio (NLR) were assessed post-CCRT. Univariate multivariate analysis for disease-free survival (DFS) overall (OS) performed using...
This study aimed to investigate the predictive factors of severe radiation-induced lung injury (RILI) in patients with cancer and coexisting interstitial disease (ILD) undergoing conventionally fractionated thoracic radiotherapy.
// Gun Oh Chong 1, * , Won Kee Lee 2, Shin Young Jeong 3 Shin-Hyung Park 4 Yoon Hee 1 Sang-Woo Dae Gy Hong Jae-Chul Kim and Soon Department of Obstetrics Gynecology, Kyungpook National University Medical Center, School Medicine, Daegu, Republic Korea 2 Research Collaboration Center in KNUH, University, Nuclear Radiation Oncology, These authors contributed equally to this work as co-first Correspondence to: Jeong, email: syjeongnm@gmail.com Keywords: intratumoral metabolic heterogeneity,...
Cervical cancer may recur after concurrent chemoradiotherapy (CCRT), even in patients with metabolic complete response (mCR) on post-CCRT F-FDG PET. We retrospectively analyzed the value of parameters, measured by pretreatment PET, as prognostic factors for predicting recurrence and death cervical mCR.In 61 who reached mCR post-CCRT, PET parameters including SUVmax, tumor volume (MTV), total lesion glycolysis (TLG) primary tumors, well those metastatic lymph nodes, were pre-CCRT Total MTV...
This study aimed to compare the dosimetric profiles of electron beams (EB) and X-ray (XB) for boosting irradiation in breast cancer patients who underwent breast-conserving surgery postoperative radiotherapy. For 131 surgery, we compared plans EB XB boost after whole-breast irradiation. The organs at risk (OAR) included cardiac chambers, coronary arteries, ipsilateral lung, skin. conformity index (CI), inhomogeneity (IHI), dose-volume parameters planning target volume (PTV), OAR were...
As the availability of breast reconstruction using implants is becoming widespread and many implant recipients undergo radiation therapy, there an increasing interest in understanding potential complications associated with capsule-tissue interactions response to irradiation. Accordingly, our medical institution designed animal experiment investigate effects irradiation on capsular contracture. A total 40 mice (C57BL6) were divided into four groups according whether or not they received time...
The standard radiation dose for patients with locally rectal cancer treated preoperative chemoradiotherapy is 45-50 Gy in 25-28 fractions. We aimed to assess whether a difference exists within this fractionation range.A retrospective analysis was performed compare three schedules. Patients received 50 25 fractions (group A), 50.4 28 B), or 45 C) the whole pelvis, as well concurrent 5-fluorouracil. Radical resection scheduled 8 weeks after chemoradiotherapy.Between September 2010 and August...
This study aimed to develop a prognosis-predicting model based on [18F]fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and clinicopathologic factors in locally advanced cervical cancer patients treated with concurrent chemoradiotherapy (CCRT). The medical records of 270 who were CCRT collected from three institutions reviewed retrospectively. A nomogram was used for predicting 2-year disease-free survival (DFS) 5-year overall (OS) Cox proportional hazards...
This study was to evaluate the prognostic value of metabolic parameters on F-18-FDG PET/CT and status human papillomavirus (HPV) infection known variables for predicting tumor recurrence investigating a model in patients with locally advanced cervical cancer treated concurrent chemoradiotherapy (CCRT).A total 129 squamous cell carcinoma who underwent initial CCRT were eligible this study. Univariate multivariate analyses performed using traditional factors, parameters, HPV infection....
Background: Our previous study demonstrated that tumor budding (TB) status was associated with inferior overall survival in cervical cancer. The purpose of this is to evaluate whether radiomic features can predict TB cancer patients. Methods: Seventy-four patients who underwent preoperative MRI and radical hysterectomy from 2011 2015 at our institution were enrolled. randomly allocated the training dataset (n = 48) test 26). Tumors segmented on axial gadolinium-enhanced T1- T2-weighted...
To determine the necessity of postmastectomy radiotherapy (PMRT) and which regions would be at risk for recurrence, we evaluated local regional recurrence in breast cancer patients with 1-3 positive nodes a tumor size <5 cm.We retrospectively analyzed data 133 female nodes, cm who were treated mastectomy followed by adjuvant systemic therapy between 2007 2016. The median follow-up period was 57 months (range, 12 to 115 months). Most (82.7%) axillary lymph node dissection. Adjuvant...