A5013888618- Asthma and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Mast cells and histamine
- Blood groups and transfusion
- IL-33, ST2, and ILC Pathways
- Neuroendocrine Tumor Research Advances
- Parasites and Host Interactions
- IgG4-Related and Inflammatory Diseases
- Complement system in diseases
- Autoimmune Bullous Skin Diseases
- Skin and Cellular Biology Research
- Research on Leishmaniasis Studies
- Amoebic Infections and Treatments
- Psoriasis: Treatment and Pathogenesis
- Neonatal skin health care
- Monoclonal and Polyclonal Antibodies Research
Erasmus MC
2013-2022
Monash University
2019
Erasmus University Rotterdam
2013
While treatment for atopic rhinitis is aimed mostly to relieve symptoms, only allergen-specific immunotherapy (AIT) targeted modify the natural history of allergic diseases. This results in sustained clinical tolerance, even when has stopped. The immunomodulatory effects AIT are attributed mainly increased regulatory T-cell function and IgG4 , yet little known about effect on memory B-cell compartment.We examine IgE- IgG subclass-expressing B cells.We recruited 29 patients with seasonal...
Despite the critical role of soluble IgE in pathology IgE-mediated allergic disease, little is known about abnormalities memory B cells and plasma that produce patients. We here applied a flow cytometric approach to cross-sectionally study blood IgE+ plasmablasts 149 children with atopic dermatitis, food allergy, and/or asthma correlated these helper T(h)2 eosinophils. Children disease had increased numbers IgE+CD27- IgE+CD27+ plasmablasts, as well eosinophils Th2 cells. plasmablast...
Antibody responses are thought to play an important role in control of Schistosoma infections, yet little is known about the phenotype and function B cells human schistosomiasis. We set out characterize cell subsets receptor Toll-like 9 stimulation Gabonese schoolchildren with haematobium infection. Frequencies memory (MBC) were increased, whereas naive frequencies reduced schistosome-infected group. At functional level, isolated from children showed higher expression activation marker CD23...
Comel-Netherton syndrome (NS) is a rare autosomal disease, characterized by severe skin hair shaft defects, atopic diathesis, and increased susceptibility for infections. Since patients with NS suffer from recurrent infections, it has been hypothesized that an underlying immunodeficiency attributes to this. Here, we studied clinical immunological characteristics of the cohort in Netherlands order identify whether potential immunodeficiencies result risk infectious complications.Phenotypes...
Summary Background Treatment of atopic dermatitis ( AD ) is focused on topical anti‐inflammatory therapy, epidermal barrier repair and trigger avoidance. Multidisciplinary treatment in both moderate maritime alpine climates can successfully reduce disease activity children with . However, it remains unclear whether abnormalities B cell T memory normalize this differs between strategies. Objective To determine successful normalizes B‐ lymphocytes to severe Methods The study was performed the...
BackgroundIndolent systemic mastocytosis (ISM) is characterized by pathologic accumulation of mast cells. The mechanism behind its phenotypic heterogeneity not well understood. Interaction cells with other immune might cause inflammation and thereby associated symptoms.ObjectiveWe investigated peripheral leukocyte compartments serum proteome in ISM.MethodsPeripheral blood phenotyping using flow cytometry a cohort 18 adults ISM 12 healthy controls. Targeted proteomics was performed to measure...