A5008366637- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- Antimicrobial Resistance in Staphylococcus
- Orthopedic Infections and Treatments
- Cardiac Structural Anomalies and Repair
- Streptococcal Infections and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Infectious Diseases and Tuberculosis
- Infectious Aortic and Vascular Conditions
- Bacterial Identification and Susceptibility Testing
- Neurogenetic and Muscular Disorders Research
- Aortic Disease and Treatment Approaches
- Antibiotic Use and Resistance
- Microbial Metabolism and Applications
- Biochemical and Structural Characterization
- Mycobacterium research and diagnosis
- Congenital heart defects research
- Healthcare cost, quality, practices
- Bacterial Infections and Vaccines
- Peptidase Inhibition and Analysis
- Williams Syndrome Research
- Health Systems, Economic Evaluations, Quality of Life
- Whipple's Disease and Interleukins
Hôpital de la Timone
2017-2024
Assistance Publique Hôpitaux de Marseille
2022-2023
Méditerranée Infection Foundation
2020
Aix-Marseille Université
2017-2020
Institut de Recherche pour le Développement
2020
Objective The primary objective was to assess the characteristics and prognosis of pyogenic spondylodiscitis (PS) in patients with infective endocarditis (IE). secondary objectives were factors associated occurrence PS. Methods Prospective case–control bi-centre study 1755 definite IE (n=150) or without (n=1605) Clinical, microbiological prognostic variables recorded. Results Patients PS older (mean age 69.7±18 vs 66.2±14; p=0.004) had more arterial hypertension (48% 34.5%; p<0.001)...
We aimed to assess the role of multimodality imaging (MMI) in diagnosis marantic endocarditis (ME) associated with cancers and describe clinical characteristics, management, outcome these patients.In a retrospective multicentric study including four tertiary centres for treatment France Belgium, patients ME were included. Demographic, MMI [echocardiography, computed tomography (CT), 18F-fluorodeoxyglucose positron emission tomography/computed (18F-FDG PET/CT)], management data collected....
Platelets have largely demonstrated their implication in anti-infectious immunity. This effect is ensured by the secreted molecules stored mostly platelet alpha granules. Previous studies reported that Staphylococcus aureus showed sensitivity to this antibacterial of platelets. Statins, for part, shown a modulating on activation. Furthermore, several protective statins staphylococcal endocarditis. The aim study was investigate influence washed Blood samples were collected from healthy donors...
Whether left ventricular non-compaction (LVNC) bears a different prognosis than dilated cardiomyopathy (DCM) is still matter of debate.From multicenter French prospective registry, we compared the outcomes 98 patients with LVNC and 65 DCM. The primary endpoint combined cardiovascular death, heart transplantation, hospitalization for events. two groups presented similar but ejection fractions (LVEF) (43.3% in vs. 35.95% DCM, p = 0.001). For this reason, subgroup analysis was performed...
Abstract Aims To determine the prognosis of patients treated for infective endocarditis (IE) according to their healthcare pathway. assess how ESC guidelines are implemented concerning performance transoesophageal echocardiography, use antibiotic therapy, and valve surgery; compare epidemiological profile IE type centres in which hospitalized. Methods results In a prospective multicentric study including 22 hospitals South-East France, 342 were classified into three groups pathway: 119...
Abstract Funding Acknowledgements Type of funding sources: None. Background Despite the increasing number studies concerning Left Atrial Strain (LAS), few data are available comparing LAS patients with cardiac amyloidosis (CA) and sarcomeric hypertrophic cardiomyopathies (HCM). Purposes We aimed to perform a comparative multimodal imaging analysis prospective cohort CA HCM. Methods For each enrolled patient, we performed same-day two three-dimension echocardiography (TTE) magnetic resonance...
Approximately half of hypertrophic cardiomyopathy (HCM) patients lack a precise genetic diagnosis. The likelihood identifying clinically relevant variants increased over time. In this study, we conducted gene-centric reanalysis exome data 200 HCM cases 5 years after the initial analysis. This prioritized genes with matched entry in OMIM database and recently emerging HCM-associated gathered using text mining-based literature review. Further classification identified was performed Clinical...
Abstract Background Early diagnosis of cardiac amyloidosis (CA) is challenging. Several echocardiographic (echo) parameters have been proposed to differentiate CA from hypertrophic cardiomyopathy (HCM), but their respective value debated. known be characterized by a more severe decline in longitudinal deformation as compared with radial function (LVEF). This characteristic justified the use ejection fraction strain ratio (EFSR) these patients. However, since dysfunction usually predominates...
Abstract Background 18-Fluorodeoxyglucose Positron emission tomography (18F-FDG PET/CT) has been shown to be useful for the diagnosis of IE, but its prognostic value is unknown. Objectives This study sought assess 18F-FDG PET/CT in prosthetic (PVE) and native valve endocarditis (NVE). Methods We prospectively studied 173 consecutive patients (109 PVE 64 NVE) with definite IE who underwent a were follow-up one year. Primary end-point was composite major cardiac events i.e. death, recurrence...
Mitral valve prolapse (MVP) is a common valvular heart defect with variable outcomes. Several studies reported MVP as an underestimated cause of life-threatening arrhythmias and sudden cardiac death (SCD), mostly in young adult women. Herein, we report clinical genetic investigation family bileaflet history syncopes resuscitated death. Using based whole exome sequencing, identified two missense variants the SCN5A gene. A rare variant SCN5A:p.Ala572Asp well-known functional SCN5A:p.His558Arg...
Abstract Funding Acknowledgements Type of funding sources: None. Background/Introduction Sudden cardiac death (SCD) is a major issue in hypertrophic cardiomyopathy (HCM) management, and its risk prediction stays challenging for clinicians. Ventricular arrythmias (VAs) have to be treated rapidly, indeed VAs lower prognosis HCM patients. Current ESC guidelines cardioverter-defibrillator implantation include left atrial (LA) whereas ventricle (LV) ejection function (LVEF) incorporated AHA...