A5061968051- Renal Diseases and Glomerulopathies
- Immune Response and Inflammation
- Lymphatic System and Diseases
- Chronic Kidney Disease and Diabetes
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Systemic Sclerosis and Related Diseases
- Mast cells and histamine
- Reproductive System and Pregnancy
- Muscle and Compartmental Disorders
- Lymphatic Disorders and Treatments
- Apelin-related biomedical research
- Neuroinflammation and Neurodegeneration Mechanisms
- Pulmonary Hypertension Research and Treatments
- Acute Kidney Injury Research
- Chemokine receptors and signaling
- Fatty Acid Research and Health
- Inflammasome and immune disorders
- Tuberous Sclerosis Complex Research
- Bladder and Urothelial Cancer Treatments
- Hematopoietic Stem Cell Transplantation
- Dialysis and Renal Disease Management
- Body Contouring and Surgery
- Protease and Inhibitor Mechanisms
- Autoimmune and Inflammatory Disorders Research
Rega Institute for Medical Research
2016-2024
KU Leuven
2016-2024
University Medical Center Groningen
2012-2024
University of Groningen
2012-2024
Renal fibrosis leads to end-stage renal disease demanding replacement therapy because no adequate treatment exists. IFN-γ is an antifibrotic cytokine that may attenuate fibrosis. Systemically administered causes side effects be prevented by specific drug targeting. Interstitial myofibroblasts are the effector cells in fibrogenesis. Here, we tested hypothesis cell-specific delivery of platelet-derived growth factor receptor β (PDGFRβ)-expressing attenuates obstructive nephropathy [unilateral...
Proteinuria is an important cause of progressive tubulo-interstitial damage. Whether proteinuria could trigger a renal lymphangiogenic response has not been established. Moreover, the temporal relationship between development fibrosis, inflammation and lymphangiogenesis in chronic kidney disease clear yet. Therefore, we evaluated time course lymph vessel (LV) formation relation to interstitial damage rat model unilateral adriamycin nephrosis. kidneys were up 30 weeks after induction LVs...
Renal fibrosis is a serious clinical problem resulting in the greatest need for renal replacement therapy. No adequate preventive or curative therapy available that could be clinically used to target specifically. The search new efficacious treatment strategies therefore warranted. Although vitro models using homogeneous cell populations have contributed understanding of pathogenetic mechanisms involved fibrosis, these poorly mimic complex vivo milieu. Therefore, we here evaluated...
Background: Ischemia-reperfusion (IR) is a major contributor to graft rejection after liver transplantation. During IR injury, an intense inflammatory process occurs in the liver. Neutrophils are considered central players events that lead injury. CXC chemokines mediate hepatic inflammation following reperfusion. However, few studies have demonstrated real-time behavior of recruited neutrophils. We used confocal intravital microscopy (IVM) image neutrophil migration and analyze parameters...
// Fariba Poosti 1,5 , Ruchi Bansal 2 Saleh Yazdani Jai Prakash Leonie Beljaars 3 Jacob van den Born 4 Martin H. de Borst Harry Goor 1 Jan-Luuk Hillebrands 1,* and Klaas Poelstra 3,* Department of Pathology Medical Biology, Division Pathology, University Center Groningen, The Netherlands Biomaterials Science Technology, Targeted Therapeutics, MIRA Institute, Twente, Enschede, Pharmacokinetics, Toxicology Targeting, Internal Medicine, Nephrology, 5 Microbiology Immunology, Laboratory...
Proteinuria is an important cause of tubulointerstitial damage. Anti-proteinuric interventions are not always successful, and residual proteinuria often leads to renal failure. This indicates the need for additional treatment modalities by targeting harmful downstream consequences proteinuria. We previously showed that triggers lymphangiogenesis before onset interstitial inflammation fibrosis. However, interrelationship these events in yet clear. To this end, we specifically blocked...
Hepatic cell death occurs in response to diverse stimuli such as chemical and physical damage. The exposure of intracellular contents DNA during necrosis induces a severe inflammatory that has yet be fully explored therapeutically. Here, we sought means neutralize the ability extracellular induce deleterious tissue inflammation when drug‐induced liver injury had already ensued. were investigated vivo using intravital microscopy. necrotic debris was studied murine livers models vitro by...
Abstract Excessive lymphangiogenesis is associated with cancer progression and renal disease. Attenuation of might represent a novel strategy to target disease although clinically approved anti-lymphangiogenic drugs are not available yet. VitaminD(VitD)-deficiency increased risk chronic kidney Presently, effects VitD on unknown. Given the apparently protective deleterious associations disease, we here tested hypothesis that has direct in vitro able attenuate vivo. In cultured mouse lymphatic...
Summary Background To recruit leucocytes to an inflammatory site, chemokine binding glycosaminoglycans ( GAG s) is critical. Therefore, strategies interfere with this interaction, aiming at the production of anti‐inflammatory agents, were developed. These include modified chemokines without affinity for G protein‐coupled receptors but enhanced s. Such compete functional binding, prevent immobilization and presentation, inhibit leucocyte migration. In addition chemokines, a ‐binding peptide...
Systemic juvenile idiopathic arthritis (sJIA) is an immune disorder characterized by fever, skin rash, and splenomegaly. Recently, increasing number of sJIA patients were reported having lung disease. Here, we explored abnormalities in a mouse model for relying on injection IFN-γ deficient (IFN-γ KO) mice with complete Freund's adjuvant (CFA). Monitoring changes during development using microcomputer tomography revealed moderate enlargement lungs, decrease aerated increase non-aerated...
Chronic kidney disease (CKD), accompanied by renal dysfunction, fibrosis, and apoptosis, is highly prevalent in postmenopausal women. We tested the hypothesis that isoflavone daidzein may ameliorate dysfunction fibrosis through angiotensin II type 1 (AT1R) 1-7 (MasR) receptors association with microRNAs 33a 27a.Two weeks before initiation of experiments, rats (n=84) underwent ovariectomy (OVX). Then, unilateral ureteral obstruction (UUO) was performed OVX rats, animals were allocated to...
Renal fibrosis accompanies all chronic kidney disorders, ultimately leading to end-stage disease and the need for dialysis or even renal replacement. As such, poses a major threat global health search effective therapeutic strategies prevent treat is highly needed. We evaluated applicability of positively charged human peptide derived from COOH-terminal domain chemokine CXCL9, namely CXCL9(74-103), intervention. Because its high density net positive charges at physiological pH, CXCL9(74-103)...
Ischemia-reperfusion injury (IRI) drives graft rejection and is the main cause of mortality after liver transplantation. During IRI, an intense inflammatory response marked by chemokine production neutrophil recruitment occurs. However, few strategies are available to restrain this excessive response. Here, we aimed interfere with function during IRI in order disrupt injured liver. For this, utilized a potent glycosaminoglycan (GAG)-binding peptide containing 30 C-terminal amino acids CXCL9...
The increasing prevalence of end-stage renal disease urges novel therapeutic strategies for the treatment chronic kidney disease. As protein kinases play a pivotal role in inflammation and fibrosis, specific kinase inhibitors have been demonstrated to be renoprotective experimental studies. However, since are also involved key physiological mechanisms such as cell differentiation, growth proliferation, these beneficial effects associated with serious side effects, limiting their clinical...