A5073761743- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Gestational Diabetes Research and Management
- Regulation of Appetite and Obesity
- Nutritional Studies and Diet
- Food composition and properties
- Diet and metabolism studies
- Proteins in Food Systems
- Child Nutrition and Water Access
- Pregnancy and preeclampsia studies
- Epigenetics and DNA Methylation
- Retinoids in leukemia and cellular processes
- Vitamin D Research Studies
- Phytase and its Applications
- Agriculture Sustainability and Environmental Impact
- Folate and B Vitamins Research
- Muscle metabolism and nutrition
- Consumer Attitudes and Food Labeling
- Peroxisome Proliferator-Activated Receptors
- Stress Responses and Cortisol
- Energy and Environment Impacts
- Nutrition, Genetics, and Disease
- Biotin and Related Studies
- Polysaccharides Composition and Applications
- Agricultural and Food Sciences
University of Toronto
2013-2021
Canada Research Chairs
2019-2021
Toronto Public Health
2019
Faculty (United Kingdom)
2019
Tecnológico de Monterrey
2008-2017
Excess vitamins, especially folate, are consumed during pregnancy but later-life effects on the offspring unknown. High multivitamin (10-fold AIN-93G, HV) gestational diets increase characteristics of metabolic syndrome in Wistar rat offspring. We hypothesized that vitamin active DNA methylation, accounts for these through epigenetic modification food intake regulatory genes. Male dams fed 10-fold folate (HFol) diet and weaned to recommended (RV) or HFol were compared with those born RV 29...
Abstract Background: Obesity is associated with increased consumption and preference for dietary fat. Experimental models of fat-induced obesity use either lard or vegetable shortening. Yet, there are no direct comparisons these commonly used fat sources, the influence their fatty acid composition, on development diet-induced obesity. Objective: To compare effects hydrogenated vegetable-shortening diets, which differ in weight gain insulin resistance rats. Methods design: Male Wistar rats...
High multivitamin (HV, tenfold AIN-93G) gestational diets fed to Wistar rats increase food intake, obesity, and characteristics of metabolic syndrome in the offspring. We hypothesized that methyl vitamins, specifically folate, HV diet contribute obesogenic phenotypes consistent with their epigenetic effects on hypothalamic intake regulatory mechanisms.Male offspring dams AIN-93G high vitamins (HMethyl; B12, B6) (Study 1) recommended folate (HVRF) 2) were compared those from vitamin (RV)...
The 2015 Canadian Community Health Survey was used to investigate the protein content and quality of diets consumed by adults (≥19 years) when plant is increased. Individuals (n = 6498) were allocated quartiles increasing proportions from foods (Quartile 1: 0-24.9%; Quartile 2: 25%-49.9%; 3: 50-74.9%; 4: 75-100%). Protein Digestibility Corrected Amino Acid Score (PDCAAS) estimated using indispensable amino acid concentrations an assumed digestibility coefficient 0.8. intakes determined...
Durum Wheat Semolina (DWS) pastas with added fababean (FB) protein flour reduce postprandial blood glucose and appetite have higher nutritional quality.
Dietary guidance and Canada's 2019 Food Guide encourage increased consumption of plant-based foods as a source dietary protein. However, there is an absence recent data on protein nutrient intakes quality Canadian patterns that might occur with plant intakes. This study compared food sources adults within groups increasing protein-containing diets. The CCHS 2015 Public-Use Microdata File single 24-hour recalls males females ≥19 years (n = 6498) or ≥70 1482) were examined. Respondents...
Rats fed gestational diets high in multivitamin or folate produce offspring of altered phenotypes. We hypothesized that female rat born to dams a diet folic acid (HFol) have compromised bone health and feeding the same HFol attenuates these effects. Pregnant rats were with either recommended (RFol) 10-fold higher amounts. Female weaned RFol for 17 weeks. maternal resulted lower body weights (6%, P = 0.03) and, after adjusting weight femoral length, smaller area (2%, 0.03), compared control...
ABSTRACT The corn tortilla plays an integral role in the Mexican diet and is ideal vehicle for micronutrient fortification. Approximately 60% of tortillas Mexico are produced from nixtamal, with remainder prepared masa flour. A process continuous fortification nixtamal was evaluated two commercial mills Mexico. powder dosifier used to add premix containing iron, zinc, folic acid, niacin, riboflavin, thiamin (1 g/kg) as it milled. After training preliminary sampling, fortified unassisted four...
High intakes of multivitamins (HV) during pregnancy by Wistar rats increase food intake, body weight, and characteristics the metabolic syndrome in male offspring. In this study, high-fat soluble vitamins were fed combination gestation to test hypothesis that they partially account for effects HV diet. Pregnant (14-16/group) a recommended multivitamin diet (1-fold all vitamins) or vitamin (HFS; 10-fold A, D, E, K) pregnancy. Offspring preference as well expression selected genes hypothalamus...
Background Obesity is associated with increased consumption and preference for dietary fat. Experimental models of fat‐induced obesity use either lard or vegetable shortening. Yet, there are no direct comparisons these commonly used fat sources, the influence their fatty acid composition on development diet‐induced obesity. Objective To compare effects hydrogenated shortening diets, which differ in composition, weight gain insulin resistance rats. Methods Design Male Wistar rats were fed ad...
Abstract Objective Chronic testosterone blood concentrations associate with food intake (FI), but acute effects of on appetite and effect protein glucose consumption response have had little examination. Methods In a randomized, crossover study, twenty‐three adolescent (12‐18 years old) males were given beverages containing either: (a) whey (1 g/kg body weight), (b) weight) or (c) calorie‐free control (C). Plasma testosterone, luteinizing hormone (LH), GLP‐1 (active), ghrelin (acylated),...
Soybean milk powder (SMP) and amaranth flour (AF) can improve the nutritional profile of bakery products. Nonetheless, these ingredients impart undesirable effects on batter rheology product texture. In this study, effect three additives (carboxymethyl cellulose(CMC), sodium stearoyl-2-lactylate (SSL), guar–xanthan gum mix (GX)) was evaluated physical, chemical textural parameters muffins baked with SMP AF. Protein content increased in all made SMP–AF. SMP–AF also muffins' hardness...
Background: Stunting during childhood has long-term consequences on human capital, including decreased physical growth, and lower educational attainment, cognition, workforce productivity wages. Literature quantified the costs of stunting to national economies however few studies have focused private sector which employs nearly 90% in many low- middle-income countries (LMICs). We aimed examine i) impact income loss LMICs; ii) quantify losses sales firms LMICs due stunting; iii) estimate...
High multivitamin (HV, 10‐fold AIN‐93G) gestational diets fed to Wistar rats produce offspring with higher food intake, obesity and characteristics of metabolic syndrome. The objective was determine if folate within the HV diet contributes obesogenic phenotype through epigenetic effects on hypothalamic regulatory mechanisms. Male dams normal (NF) (HVNF) were compared those from dams. Offspring weaned a high fat for 8 weeks. HVNF had lower intake (5%, P=0.0005), body weight (4%, P=0.03),...
High multivitamin (10‐fold, HV) or folic acid (Fol) intake alone during pregnancy leads to an obesogenic phenotype in the offspring but its effects on later post‐weaning (PW) weight gain of dams has not been reported. This study investigated whether Fol as a component HV gestational diet affects PW and associates with expression peroxisome‐proliferator activated receptor isoforms (PPAR‐α/β/γ) involved lipid metabolism adipocyte differentiation. Wistar rat were fed AIN‐93G containing either:...
Diet‐induced obesity is known to alter dopamine neurochemistry within central reward circuitry essential for coding the rewarding properties of palatable foods. Our objective was investigate whether high multivitamin (10‐fold, HV) intake during pregnancy alone, which increases post‐weaning (PW) weight gain in Wistar rat dams, affects their (DA) metabolism and related gene expression nucleus accumbens (NAc) when exposed an obesogenic environment. Pregnant rats were fed AIN‐93G diet with...