A5087230334- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Tannin, Tannase and Anticancer Activities
- Electrospun Nanofibers in Biomedical Applications
- Colorectal Cancer Treatments and Studies
- Eicosanoids and Hypertension Pharmacology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Edible Oils Quality and Analysis
- Inflammatory Bowel Disease
- Cancer Cells and Metastasis
- melanin and skin pigmentation
- Fatty Acid Research and Health
- Cancer, Stress, Anesthesia, and Immune Response
- NF-κB Signaling Pathways
- Gut microbiota and health
- Stoma care and complications
- Organ Transplantation Techniques and Outcomes
- Nanoparticle-Based Drug Delivery
- Mycobacterium research and diagnosis
- Circular RNAs in diseases
- Telomeres, Telomerase, and Senescence
Bursa Uludağ Üni̇versi̇tesi̇
2022-2025
The effects of Olea europaea leaf extract (OLE) phenolics, including oleuropein (OL), hydroxytyrosol (HT), tyrosol (TYR), and rutin against glioblastoma (GB), independently in combination with temozolomide (TMZ), were investigated T98G A172 cells. Cell growth was assessed by WST-1, real-time cell analysis, colony formation, cycle distribution assays. A dual acridine orange propidium iodide (AO/PI) staining annexin V assay determined viability. sphere-forming assay, an intracellular oxidative...
Congenital lung malformations (CLMs) refer to structural abnormalities of the lungs that occur during fetal development. Matrix metalloproteinases (MMPs) constitute a group zinc-dependent enzymes, with certain members this family playing pivotal roles in remodeling both prenatally and postnatally. This study aimed explore expression levels MMP-2, MMP-7, MMP-9 CLMs which are recognized as contributors their clinical pathology. A total 41 patients between ages 0-17 years had undergone surgery...
The purpose of this study was to investigate the effect Olea europaea L. leaf extract (OLE) on senescence and senescence-associated secretory phenotype (SASP) caused by temozolomide (TMZ) in glioblastoma (GB).A β-galactosidase assay a colony formation were used determine effects OLE, TMZ, OLE + TMZ cellular aggressiveness GB cell lines T98G U87MG. mRNA expression levels p53, factor, interleukin (IL)-6, matrix metalloproteinases (MMP)-9, nuclear factor kappa B1 (NF-κB1) as SASP factors Bcl-2...
Metastasectomy of liver metastases colorectal cancer (CRC) offers the greatest likelihood cure. Nevertheless, recurrence rates after this procedure are high, and chemotherapy is a reasonable choice with inconclusive evidence. In our study, we aimed to investigate parameters that can be used predict development metastasectomy by examining clinical, pathological molecular markers in primary tumor their metastases. Epithelial-mesenchymal-Transition (EMT) mechanism, stem cell (CSC) RAS, mTOR,...
<title>Abstract</title> Infliximab (IFX) is widely used in the treatment of inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn's disease (CD). Still, long-term use may be ineffective or suggest some side effects. This study investigated role Myricetin, a flavonoid, alone its complementary therapeutic potential combination with IFX against UC, CH, cancerization. DSS triggered development acute UC syndromes Wistar albino rats, while TNBS symptoms seen CD. The...
The overall survival of patients with the advanced and recurrent gastric cancer (GC) remains unfavorable. In particular, this is due to spreading resistance chemotherapy associated epithelial-mesenchymal transition (EMT) tumor cells. EMT can be identified by transcriptome profiling GC for markers. Indeed, analysis TCGA GTEx databases (n= 408) acohortof 43) revealed that expression theCDH2gene was significantly decreased in tumors vs. non-tumor tissues correlated patients. Expression...
Total resection of glioblastoma (GB) tumors is nearly impossible, and systemic administration temozolomide (TMZ) often inadequate. This study presents a hybrid layered composite nanofiber mesh (LHN) designed for localized treatment in GB tumor bed. The LHN, consisting polyvinyl alcohol core-shell polylactic acid layers, was loaded with TMZ rutin.
Aim: The risk of colorectal cancer development associated with low-grade dysplasia (LGD) and high-grade (HGD) colon polyps at baseline polypectomy remains unclear.In this study, we investigated the role microsatellite instability (MSI) in formation prognosis dysplasia.Method: In 40 diagnosed as HGD, LGD were evaluated according to revised Vienna criteria (2015) a result polypectomy.MSI analysis was performed by fragment using five different primers.Results: Three eight HGD turned into during...
This study was conducted to examine the dose-related effects over time of oleuropein on proliferation and area tumor spheroids in hepatocellular carcinoma cells.We examined possible 100 500 μM dose concentrations HepG2 cell using a real-time analyzer. A 3-dimensional spheroid model established by seeding cells at density 160 cells/well custom 96-well microplates with low attachment surfaces culturing for 3 days. Tumor spheres were treated increasing doses 72 hours, images captured every 24...
Introduction: Metastasectomy is one of the effective treatment methods for liver metastases developing from primary colorectal cancer (CRC). However, recurrence after metastasectomy biggest problem in these cancers. 
 The present study aimed to examine role Epithelial-Mesenchymal Transition (EMT) development CRCs.
 Materials and Methods: In study, 85 patients were evaluated. RNA was isolated archive tumors normal tissues patients. Expression profiles 7 different EMT markers...
To describe the role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in glioblastoma (GB) progression patients concurrently diagnosed with diabetes mellitus (DM).Formalin-fixed paraffin-embedded (FFPE) tumor samples 47 GB only and 13 DM (GB-DM) were enrolled this study. Data for p53 Ki67 immunohistochemical staining tumors blood HbA1c levels retrospectively collected. MALAT1 expression was assessed using quantitative real-time polymerase chain reaction.The coexistence...