A5069416847- Insect Resistance and Genetics
- Plant-Microbe Interactions and Immunity
- Malaria Research and Control
- Mosquito-borne diseases and control
- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- Advanced Antenna and Metasurface Technologies
- Insect-Plant Interactions and Control
- Plant Parasitism and Resistance
- Plant Pathogens and Resistance
- Invertebrate Immune Response Mechanisms
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Metamaterials and Metasurfaces Applications
- Antenna Design and Analysis
- Insect symbiosis and bacterial influences
- Legume Nitrogen Fixing Symbiosis
- Infectious Diseases and Mycology
- Respiratory viral infections research
- Plant Pathogens and Fungal Diseases
- Toxin Mechanisms and Immunotoxins
- Viral Infections and Immunology Research
- Fungal Biology and Applications
- Plant Pathogenic Bacteria Studies
- Silicon Nanostructures and Photoluminescence
Second Hospital of Anhui Medical University
2025
Anhui Medical University
2025
The First Affiliated Hospital, Sun Yat-sen University
2025
Zhongshan Hospital
2025
Fudan University
2015-2025
Sun Yat-sen University
2025
Nanjing Agricultural University
2014-2024
Numerical Method (China)
2022-2023
China Academy of Launch Vehicle Technology
2023
Guangzhou University of Chinese Medicine
2023
报道上海第l例确诊新型冠状病毒（2019-nCoV）感染患儿的诊治经过。患儿 男，7岁，因"发热3 h伴咳嗽"以及父亲被确诊2019-nCoV感染的肺炎收入复旦大学附属儿科医院负压病房。经过对症治疗后治愈。儿童2019-nCoV感染临床表现相对成人较轻，家庭内传播是儿童感染重要的途径。本例患儿虽然症状轻，但恢复期连续2次2019-nCoV核酸检测阳性，提示需要观察轻症儿童病例在恢复期无症状排毒的传染性。.
Abstract The mirid bug Apolygus lucorum has become a major agricultural pest since the large-scale cultivation of Bt-cotton. It was assumed that A. lucorum, similarly to other phloem sap insects, could secrete saliva contains effector proteins into plant interfaces perturb host cellular processes during feeding. However, secreted effectors are still uncharacterized and unstudied. In this study, 1878 putative were identified from transcriptome which either had homology with published aphid or...
Phytophthora genomes encode a myriad of Crinkler (CRN) effectors, some which contain putative kinase domains. Little is known about the host targets these kinase-domain-containing CRNs and their infection-promoting mechanisms. Here, we report target functional mechanism conserved CRN effector named CRN78 in notorious oomycete pathogen, sojae . promotes capsici infection Nicotiana benthamiana enhances P virulence on plant Glycine max by inhibiting H 2 O accumulation immunity-related gene...
RXLR effectors, a class of secreted proteins that are transferred into host cells to manipulate immunity, have been reported widely exist in oomycetes, including those from genera Phytophthora, Hyaloperonospora, Albugo, and Saprolegnia. However, Pythium species, no effector has yet characterized, the origin evolution such virulent effectors still unknown. Here, we developed modified regular expression method for de novo identification RXLRs characterized 359 putative nine species....
Abstract RNA-binding proteins (RBPs) participate in a diverse set of biological processes plants, but their functions and underlying mechanisms plant–pathogen interactions are largely unknown. We previously showed that Arabidopsis thaliana BPA1-LIKE PROTEIN3 (BPL3) belongs to conserved plant RBP family negatively regulates reactive oxygen species (ROS) accumulation cell death under biotic stress. In this study, we demonstrate BPL3 suppresses FORKED-LIKE7 (FL7) transcript raises levels the...
Post-cardiac arrest brain injury (PCABI) remains the main cause of death and poor prognosis in patients after resuscitation. In June 2024, International Liaison Committee on Resuscitation (ILCOR) released a scientific statement improving PCABI based relevant research progress. The proposed pathological mechanism PCABI, explored reasons why previous preclinical data could not be translated into clinical practice, outlined possible future directions for advancement. This article interprets key...
Background Sepsis-associated liver injury (SALI) is a frequent and lethal complication among critically ill patients in the intensive care unit (ICU). Despite its significance, there has been notable lack of specialized tools for evaluating in-ICU mortality risk these patients. This study seeks to address this gap by developing practical nomogram predict factors associated with suffering from SALI. Methods Data were extracted MIMIC-IV database, Critical Care Public Medical Information Mart....
Abstract Background Rabies remains a devastating and fatal infectious disease worldwide. To date, vaccination is the most reliable effective strategy for controlling rabies. However, despite effectiveness of inactivated vaccines, cumbersome procedures high costs post-exposure prophylaxis impose significant economic burden, particularly in developing countries with limited access to vaccines. Therefore, there an urgent need develop novel rabies vaccine that reduces while enhancing safety...
Understanding phylogenetic relationships within species complexes of disease vectors is crucial for identifying genomic changes associated with the evolution epidemiologically important traits. However, high degree genetic similarity among sibling confounds ability to determine using molecular markers. The goal this study was infer ancestral-descendant malaria and nonvectors Anopheles gambiae complex by analyzing breakpoints fixed chromosomal inversions in ingroup several outgroup species....
Pythium guiyangense, an oomycete from a genus of mostly plant pathogens, is effective biological control agent that has wide potential to manage diverse mosquitoes. However, its mosquito-killing mechanisms are almost unknown. In this study, we observed P. guiyangense could utilize cuticle penetration and ingestion mycelia into the digestive system infect mosquito larvae. To explore pathogenic mechanisms, high-quality genome sequence with 239 contigs N50 contig length 1,009 kb was generated....
Riptortus pedestris (Fabricius) is a polyphagous hemipteran crop pest that mainly feeds on the leguminous plants, resulting in shriveled and dimpled seeds. With recent several outbreaks Huang-Huai-Hai region of China, as well South Korea Japan, this species has caused enormous economic losses to soybean crops. In present study, we found R. feeding results local lesions at infestation sites. To identify key effectors induce plant damage during feeding, salivary glands were dissected for...
Nonrandom distribution of rearrangements is a common feature eukaryotic chromosomes that not well understood in terms genome organization and evolution. In the major African malaria vector Anopheles gambiae, polymorphic inversions are highly nonuniformly distributed among five chromosomal arms associated with epidemiologically important adaptations. However, it clear whether genomic content inversion polymorphism fixation rates.To better understand evolutionary dynamics inversions, we...
To facilitate physical genome mapping, we have developed a new cytogenetic photomap for Anopheles stephensi (Liston) (Diptera: Culicidae), an important malaria vector in Asia. The high-resolution images of the ovarian polytene chromosomes been straightened and divided by numbered divisions lettered subdivisions. exact chromosomal locations eight DNA probes determined fluorescent situ hybridization. Using sequences, established correspondence between arms among An. stephensi, gambiae...
Physical mapping is a useful approach for studying genome organization and evolution as well sequence assembly. The availability of polytene chromosomes in malaria mosquitoes provides unique opportunity to develop high-resolution physical maps. We report 0.6-Mb-resolution map consisting 422 DNA markers hybridized 379 chromosomal sites the Anopheles stephensi chromosomes. This makes An. second only gambiae density among mosquitoes. Three hundred sixty-three (363) probes single sites, whereas...
Abstract The aim of this study was to investigate whether a moderate‐intensity static magnetic field (SMF) can enhance the killing effect adriamycin (ADM) on K562 cells, and explore effects SMF combined with ADM cells. We analyzed metabolic activity cell cycle distribution, DNA damage, change in ultrastructure, P‐glycoprotein (P‐gp) expression after cells were exposed continuously uniform 8.8 mT for 12 h, or without ADM. Our results showed that (25 ng/ml) significantly inhibited ( P <...
Abstract The oomycete pathogen Phytophthora capsici encodes hundreds of RXLR effectors that enter the plant cells and suppress host immunity. Only a few these genes are conserved across different strains species. Such core might target hub immune pathways in hosts. Here, we describe functional characterization P. effector RXLR242. expression RXLR242 was up‐regulated during infection, its ectopic Nicotiana benthamiana , an experimental host, further promoted infection. physically interacted...
The malaria mosquito species of subgenus Cellia have rich inversion polymorphisms that correlate with environmental variables. Polymorphic inversions tend to cluster on the chromosomal arms 2R and 2L but not X, 3R 3L in Anopheles gambiae homologous other species. However, it is unknown whether polymorphic distantly related from nonrandomly share similar sets genes. It also unclear if evolutionary breakage inversion-poor under constraints. To gain a better understanding arm-specific...
Valsa pyri is the causal agent of pear canker disease, which leads to enormous losses production in eastern Asian, especially China. In this study, we identified a fungal-specific transcription factor 1 (termed as VpFSTF1) from V. pyri, highly conserved fungi. To characterize its functions, generated mutant and complementation strains found that ΔVpFSTF1 mutants lost ability form fruiting bodies along with reduced virulence. The radial growth was sensitive increasing concentrations hydrogen...
Plants deploy various immune receptors to recognize pathogen-derived extracellular signals and subsequently activate the downstream defense response. Recently, increasing evidence indicates that endoplasmic reticulum (ER) plays a part in plant response, known as ER stress-mediated immunity (ERSI), halts pathogen infection. However, mechanism for stress response of infection remains unclear. Here, we characterized regulator NAC089, which was previously reported positively regulate programed...
Summary Apolygus lucorum (Meyer‐Dur; Heteroptera: Miridae) is a major agricultural pest infesting crops, vegetables, and fruit trees. During feeding, A. secretes plethora of effectors into its hosts to promote infestation. However, the molecular mechanisms these manipulating plant immunity are largely unknown. Here, we investigated mechanism underlying effector Al106 manipulation plant–insect interaction by RNA interference, electrical penetration graph, insect pathogen bioassays,...
The mirid bug (Riptortus pedestris), a major soybean pest, migrates into fields during the pod filling stage and causes staygreen syndrome, which leads to substantial yield losses. mechanism by R. pedestris elicits (Glycine max) defenses counter-defenses remains largely unexplored. In this study, we characterized protein family from pedestris, designated Riptortus HAMP 1 (RPH1) its putative paralogs (RPH1L1, 2, 3, 4, 5), whose members exhibit dual roles in triggering inhibiting plant...
In the near future, inactivated enterovirus 71 (EV71) vaccine is expected to become available on market in China. Since EV71 a major cause of hand, foot and mouth disease (HFMD), significantly reduce number cases, as well detrimental economic effect disease. However, for national vaccination strategy be developed, policy-makers need more information socioeconomic burden HFMD infection. Based 2011 population data, we estimated clinical infection children aged 0-9 years Shanghai, The annual...