A5000484673- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac pacing and defibrillation studies
- Enhanced Recovery After Surgery
- Abdominal Surgery and Complications
- Cardiac Valve Diseases and Treatments
- Nutrition and Health in Aging
- Erythropoietin and Anemia Treatment
- GDF15 and Related Biomarkers
- Potassium and Related Disorders
- Heart Failure Treatment and Management
- Muscle Physiology and Disorders
- Anesthesia and Pain Management
- ECG Monitoring and Analysis
- Health and Medical Research Impacts
- Cardiovascular Health and Disease Prevention
- Trauma Management and Diagnosis
- Innovations in Medical Education
- Traumatic Ocular and Foreign Body Injuries
- Empathy and Medical Education
- Cardiovascular Function and Risk Factors
- Aortic aneurysm repair treatments
- Cell Adhesion Molecules Research
- Atrial Fibrillation Management and Outcomes
University of Cambridge
2017-2024
Papworth Hospital NHS Foundation Trust
2020-2023
Cambridge University Hospitals NHS Foundation Trust
2023
Cambridge School
2023
UCLA Health
2018-2019
Addenbrooke's Hospital
2019
Abstract Aims Heart failure and associated cachexia is an unresolved important problem. This study aimed to determine the factors that contribute cardiac in a new model of heart mice lack integrated stress response (ISR) induced eIF2α phosphatase, PPP1R15A. Methods results Mice were irradiated reconstituted with bone marrow cells. lacking functional PPP1R15A, exhibited dilated cardiomyopathy severe weight loss following irradiation, whilst wild-type unaffected. was increased expression Gdf15...
Ageing and several age-related chronic conditions including obesity, insulin resistance hypertension are associated with mitochondrial dysfunction represent independent risk factors for atrial fibrillation (AF).Atrial arrhythmogenesis was investigated in Langendorff-perfused young (3-4 month) aged (>12 month), wild type (WT) peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β-/-) murine hearts modeling age-dependent during regular pacing programmed electrical...
Abstract Long QT Syndrome 3 (LQTS3) arises from gain-of-function Na v 1.5 mutations, prolonging action potential repolarisation and electrocardiographic (ECG) interval, associated with increased age-dependent risk for major arrhythmic events, paradoxical responses to β-adrenergic agents. We investigated independent interacting effects of age S cn5a + /ΔKPQ genotype in anaesthetised mice modelling LQTS3 on ECG phenotypes before following β-agonist challenge, upon fibrotic change. Prolonged...
Objectives Although cardiovascular disease (CVD) is a common comorbidity associated with chronic obstructive pulmonary (COPD), it unknown how to improve prediction of (CV) risk in individuals COPD. Traditional CV scores have been tested different populations but not uniquely The potential alternative markers COPD unknown. We aimed determine the predictive value conventional CVD factors and if additional beyond factors. Design Data from Evaluation Role Inflammation Chronic Airways cohort,...
Key Teaching Points•Intraseptal ventricular tachycardia can be difficult to ablate using conventional unipolar ablation methods.•Bipolar produce successful intraseptal lesions by delivering energy between catheters positioned in the left and right ventricle.•Venoarterial extracorporeal membrane oxygenation safely provide hemodynamic support high-risk patients. •Intraseptal
Abstract Heart failure and associated cachexia is an unresolved important problem. We report a new model of severe heart that consistently results in cachexia. Mice lacking the integrated stress response (ISR) induced eIF2α phosphatase, PPP1R15A, exhibit dilated cardiomyopathy weight loss following irradiation, whilst wildtype mice are unaffected. This with increased expression Gdf15 levels GDF15 circulation. provide evidence blockade activity prevents slows progression failure. Our data...
We thank Drs Futyma and Kułakowski for their interest insights regarding our case report how it relates to the increasing utilization of bipolar ablation challenging ventricular tachycardia (VT) substrates. This was one early ablations performed at center therefore power conservative, with gradual up-titration after assessing lack complications lower power. The long-term clinical control incessant unipolar-resistant VT, as well dramatic septal morphologic wall motion changes noted on...
An 80-year-old woman with coronary artery disease, mitral regurgitation and persistent atrial fibrillation intermittent rapid ventricular rate was accepted for Coronary Artery Bypass Grafting (CABG) epicardial lead insertion, at a joint CTS-cardiology meeting. A porcelain aorta found