A5023370588- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Contact Dermatitis and Allergies
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Respiratory and Cough-Related Research
- Medicine and Dermatology Studies History
- Medical and Health Sciences Research
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Hair Growth and Disorders
- Cutaneous Melanoma Detection and Management
- Occupational exposure and asthma
- Stress Responses and Cortisol
- Liver Diseases and Immunity
- Drug-Induced Adverse Reactions
- Tattoo and Body Piercing Complications
- Advancements in Transdermal Drug Delivery
- Food Allergy and Anaphylaxis Research
- Cutaneous lymphoproliferative disorders research
- Complementary and Alternative Medicine Studies
- Metabolism, Diabetes, and Cancer
- Dermatologic Treatments and Research
Novo Nordisk (Denmark)
2024
Gentofte Hospital
2014-2019
University of Copenhagen
2014-2019
ABSTRACT Background Semaglutide, a glucagon‐like peptide‐1 receptor agonist, has demonstrated potential beneficial effects in metabolic dysfunction‐associated steatohepatitis (MASH). Aims To describe the trial design and baseline characteristics of ‘Effect Semaglutide Subjects with Non‐cirrhotic Non‐alcoholic Steatohepatitis’ (ESSENCE) (NCT04822181). Methods ESSENCE is two‐part, phase 3, randomised, multicentre evaluating effect subcutaneous semaglutide 2.4 mg participants biopsy‐proven MASH...
Abstract Background Patient‐reported triggers for atopic dermatitis ( AD ) flares include changes in ultraviolet irradiation, humidity and temperature. Objectives To identify the relationships between weather data healthcare utilization patients. Methods Using nationwide registries, clinic (1994–2012) hospital visits (1977–2012) treatment were calculated as well monthly totals of topical corticosteroid TCS (1996–2012) calcineurin inhibitor TCI prescriptions (2003–20012) filled by We averages...
Natural moisturizing factor (NMF) is used as genotypic and phenotypic biomarker in diagnostics. This study a side-to-side comparison of two different methods to determine NMF atopic dermatitis patients: Raman microspectroscopy stratum corneum tape stripping followed by HPLC.Measured values were significantly correlated (R2 = .61; p < .0001), both demonstrated concentration-depth dependence reduced levels the carriers filaggrin null mutations. Good agreement between measurements left right...
During the winter in northern countries, risk of dermatitis is increased due to low temperature and humidity. Dermatitis particularly common on weather‐exposed skin such as cheeks hands. Recently, numbers unidentified nanosized protrusions corneocyte surface were associated with deficiency natural moisturizing factor (NMF). To investigate effect season NMF levels texture cheek hand healthy adults. Eighty volunteers (40 male 40 female) recruited: aged 18–40 years ≥ 70 years. Cheek dorsal was...
Atopic dermatitis (AD) is characterized by skin barrier dysfunction. Notably, a high number of nano-scale protrusions on the surface corneocytes, which can be expressed Dermal Texture Index (DTI), were recently associated with paediatric AD, loss-of-function mutations in filaggrin gene (FLG) and reduced levels natural moisturizing factors (NMF). No study has so far examined association between these parameters monomeric adults.To determine DTI, NMF healthy controls group patients controlled...
Epidermal deficiency of filaggrin, and the derived natural moisturizing factors (NMFs), is associated with increased risk atopic dermatitis (AD). While filaggrin gene mutations cause deficiency, there limited insight into causative environmental factors.To explore effect selected exogenous skin stressors on NMF cytokine levels in healthy adult epidermis.Forty volunteers (aged 18-49 years) were exposed to hard, soft chlorinated water, 0·5% sodium lauryl sulfate, house dust mite, cat allergen,...
Abstract Background Epidermal filaggrin deficiency due to common gene ( FLG ) mutations causes xerosis and strongly increases the risk of atopic dermatitis even asthma. However, it is unknown whether independent could also increase Objective To evaluate generalized was associated with asthma, in a cross‐sectional study on adult Danes. Methods A total 3396 adults from general population participated health examination. Lung function serum‐specific IgE levels inhalant allergens were measured...
Initially after tattooing, the skin barrier function is broken. However, long-term impact of clinically healed tattoos on this has never been studied. The aim was to investigate effect in normal and examples with chronic inflammatory complication.Participants were recruited from "Tattoo clinic" Dermatological Department Bispebjerg Hospital Denmark, where patients complicated tattoo reactions are treated. Transepidermal water loss (TEWL), conductance, capacitance, pH measured tattooed...
A 61-year-old non-atopic man was referred to us with complaints of recurrent and increasingly frequent episodes facial oedema, typically accompanied by erythema a burning sensation. The symptoms had affected him intermittently over 20-year period; they mostly lasted for approximately 7–14 days per episode, were followed spontaneous resolution (Fig. 1). There no history concomitant itch, urticaria, or swelling the tongue airways. patient otherwise in good health took prescription medications....
Die Haut ist eine wichtige Barriere, die den Organismus vor mechanischer Belastung, Mikroorganismen, Chemikalien und Allergenen schützt, umgekehrt aber auch Funktion erfüllt, Flüssigkeitsverlust zu reduzieren. Ein gemeinsames Kennzeichen vieler Dermatosen beeinträchtigte Funktionsfähigkeit der Hautbarriere, man könnte vermuten, dass hier durch vermehrtes Eindringen potenzieller Allergene ein erhöhtes Risiko für Kontaktsensibilisierung (CS) Allergie besteht. Beziehung zwischen häufigen...