A5100438085- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Neuroblastoma Research and Treatments
- Wnt/β-catenin signaling in development and cancer
- RNA regulation and disease
- Pituitary Gland Disorders and Treatments
- Ferroptosis and cancer prognosis
- Galectins and Cancer Biology
- RNA modifications and cancer
Tsinghua University
2025
Hebei Agricultural University
2020
Beijing Children’s Hospital
2019-2020
Capital Medical University
2011-2020
Guangdong Province Stomatological Hospital
2016
Southern Medical University
2016
The objective of this study was to investigate the role lncRNA XIST and its relationship with miR-133a in myocardial I/R injury. H9C2 cells treated by hypoxia/reoxygenation (H/R) were used establish an vitro model. small interfering RNA (siRNA) for miR-133 mimics, inhibitor, suppressor cytokine signaling (SOCS2) recombinant plasmids transfect cells. Cell apoptosis determined flow cytometry analysis, cell viability 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide, Thiazolyl...
Abstract Cardiac hypertrophy (CH) is a common cardiac disease and closely associated with heart failure. Protocadherin 17 (PCDH17) was reported to aggravate myocardial infarction. Present study designed illustrate the impact of PCDH17 mechanism expression regulation in CH. CH model vivo vitro established by transverse aortic constriction (TAC) Ang‐II treatment. Hypertrophy evaluated PMC H9c2 cells examining cell surface area hypertrophic markers. Results demonstrated that up‐regulated vitro....
Abstract Colorectal cancer (CRC) ranks among the primary causes of human mortality globally. Numerous studies have highlighted significant role PLOD3 in progression various cancers. However, exact function and underlying mechanisms CRC remains incompletely understood. To investigate expression PLOD3, qRT‒PCR, immunohistochemistry western blotting were utilized to analyze tissues adjacent normal tissues. Functional assays conducted assess roles both vitro vivo. elucidate potential mechanism...
Objective To study the diagnosis and treatment of familical hemangioblastoma with same parts central nervous system.Methods The clinical presentation, surgical outcomes in two families cerebellar three brainstem were analyzed retrospectively literature review was performed.Results Family A suspected to be VHL, family B confirmed VHL.Five tumors removed completely.The KPS all patients more than 90 during follow - up period ( from 6 months 48 ).Conclusion MRI DSA may most important methods for...
Objective To investigate the mutations of AIP gene in primary and recurrent pituitary adenomas Chinese,and to analyze correlation between relapse rate adenomas.Method 38 29 which were verified by pathology collected,and all specimens not accepted concurrent chemoradiotherapy chemo - treatment.DNA was extracted from specimens,and then proceeded PCR reaction,and DNA sequence.Results After comparing sequence investigated with Genebank,the mutation 5 12 found.There a significantly difference two...