A5065119701- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Ion Transport and Channel Regulation
- Hypothalamic control of reproductive hormones
- Sperm and Testicular Function
- Nerve injury and regeneration
- Cell Adhesion Molecules Research
- Animal Nutrition and Physiology
- Exercise and Physiological Responses
- Mycotoxins in Agriculture and Food
- Sleep and related disorders
- Biochemical Analysis and Sensing Techniques
- Blood properties and coagulation
- Selenium in Biological Systems
- Renal and related cancers
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Platelet Disorders and Treatments
- Bryophyte Studies and Records
- Hormonal Regulation and Hypertension
- Lichen and fungal ecology
- Pesticide Exposure and Toxicity
- Digestive system and related health
University of Naples Federico II
2014-2024
University of Basilicata
2011-2012
GTx (United States)
2007
Ochratoxin A (OTA) is a powerful mycotoxin found in various foods and feedstuff, responsible for subchronic chronic toxicity, such as nephrotoxicity, hepatotoxicity, teratogenicity, immunotoxicity to both humans several animal species. The severity of the liver damage caused depends on dose duration exposure. Several studies have suggested that oxidative stress might contribute increasing hepatotoxicity OTA, antioxidants, including curcumin (CURC), been tested counteract toxic hepatic action...
Ochratoxin A (OTA) is a powerful nephrotoxin and the severity of its damage to kidneys depends on both dose duration exposure. According scientific data currently available, mechanism action still not completely clarified, but it supposed that oxidative stress responsible for OTA-induced nephrotoxicity. Bioactive compound use has emerged as potential approach reduce chronic renal failure. Therefore, curcumin (CURC), due therapeutic effects, been chosen our study toxic effects induced by OTA....
Abstract In this work, we investigated the effects of red orange and lemon extract (RLE) on ochratoxin A (OTA)‐induced nephrotoxicity. particular, analyzed change in renal function oxidative stress Sprague–Dawley rats treated with OTA (0.5 mg/kg body weight, b.w.) RLE (90 by oral administration. After treatment, found alterations biochemical parameters kidney, related to a severe decrease glomerular filtration rate. The treatment normalized activity antioxidant enzymes prevented...
ABSTRACT Cyclosporine A (CsA) is the prototype of immunosuppressant drugs that has provided new perspectives in human and veterinary medicine to prevent organ transplant rejection treat certain autoimmune diseases dermatologic diseases. Unfortunately, treatment with CSA often limited by severe adverse effects such as hypertension nephrotoxicity. Some data suggest reactive oxygen species (ROS) oxidative stress play an important role its pathogenesis, particular superoxide (O 2 − ) most...
ABSTRACT Ochratoxin A (OTA) is a natural mycotoxin, involved in the development of important human and animal diseases. In this work we have studied role oxidative stress OTA nephrotoxicity effect new recombinant mitochondrial manganese containing superoxide dismutase (rMnSOD) to prevent kidney damage induced by OTA. Blood pressure, glomerular filtration rate renal histology were analyzed control rats treated rats. addition, lipid peroxidation, catalase productions measured. Our data showed...
Aquaporin-1 (AQP1), a six-transmembrane domain protein, belongs to highly conserved group of proteins called aquaporins known regulate permeability across cell membranes. Although the role AQP1 has been extensively studied, its specific activity along gastrointestinal tract in animals during early postnatal development is poorly known. This study investigates expression mRNA and protein small large intestine water buffalo calves after colostrum ingestion using reverse...
Orexins A (ox A) and B are two peptides originally discovered in neurons of rat hypothalamus, later found different cellular types the gastrointestinal genital tracts. They arise from proteolytic cleavage a common precursor molecule, prepro-orexin, bind to receptors, namely receptor 1 (ox1r) 2 for orexins, that show binding affinity. The central role has been extensively studied, whereas their activity periphery is still poorly known. Here, we investigated presence ox ox1r epididymis South...
Aquaporins (AQPs) are membrane channel proteins that play a role in regulating water permeability many tissues. To date, seven isoforms of AQPs have been reported the gastrointestinal tract different mammalian species. In contrast, both tissue distribution and expression unknown buffalo. The purpose this study was to investigate AQP4 AQP5 mRNAs their relative large intestinal tracts buffalo calves after colostrum suckling using reverse transcriptase polymerase chain reaction (RT-PCR),...
Echistatin, a snake‐venom RGD‐containing protein, was previously shown to disrupt cell‐matrix adhesion by mechanism that involves the reduction of pp125 FAK tyrosine phosphorylation levels. The aim this study establish sequence events downstream dephosphorylation could be responsible for echistatin‐induced disassembly actin cytoskeleton and focal adhesions in fibronectin‐adherent B16‐BL6 melanoma cells. results obtained show echistatin induces decrease both autophosphorylation kinase...
ABSTRACT Ochratoxin A (OTA) is a mycotoxin produced by Aspergillus and Penicillium that represent toxic real threat for human beings animal health. In this study we evaluated the effect of new recombinant mitochondrial manganese containing superoxide dismutase (rMnSOD) on oxidative stress alterations fluid reabsorption in renal proximal tubule (PT) as possible causes OTA nephrotoxicity. Finally, have measured concentration O 2 − kidney through dihydroethidium assay (DHE) nitric oxide (NO)...
There is growing evidence by the literature that unbalance between androgens and estrogens a relevant condition associated with common canine reproductive disorder known as cryptorchidism. The role of in regulating testicular cell function events supposedly due to wide expression two nuclear estrogen receptors (ERs), ER-alpha ER-beta trans-membrane G protein-coupled receptor (GPER) testis. In this study, immunohistochemistry, Western blotting qRT-PCR were used assess distribution GPER...
Nerve Growth Factor (NGF) is a member of the neurotrophin family. Neurotrophins exert their effects by binding to corresponding receptors, which are formed tyrosine protein kinases TrkA, TrkB, and TrkC, low affinity p75NTR receptor. The role neurotrophins in biology male genital organs far from clear. In particular, little known about influence sex hormones on expression receptors. present study, using immunohistochemistry real time RT-PCR, we investigated NGF TrkA vas deferens accessory...