A5004468606- Plant-Microbe Interactions and Immunity
- Plant Gene Expression Analysis
- Plant tissue culture and regeneration
- Ferroptosis and cancer prognosis
- Glioma Diagnosis and Treatment
- Plant Molecular Biology Research
- Mechanisms of cancer metastasis
- MicroRNA in disease regulation
- Cancer-related gene regulation
- S100 Proteins and Annexins
- Epigenetics and DNA Methylation
- Plant pathogens and resistance mechanisms
- Galectins and Cancer Biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Skin Protection and Aging
- Extracellular vesicles in disease
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Animal Virus Infections Studies
- Microbial infections and disease research
- RNA Research and Splicing
- Dermatology and Skin Diseases
- Polysaccharides and Plant Cell Walls
- Plant Parasitism and Resistance
Hebei Medical University
2019-2024
Second Hospital of Hebei Medical University
2019-2024
Kunming University of Science and Technology
2021-2024
Air Force Medical University
2020
Xijing Hospital
2020
Although it is well-known that human skin aging accompanied by alteration in the microbiota, we know little about of how composition this changes during course and effects age-related microbes on aging. Using 16S rDNA ITS sequencing to profile microbiomes 160 samples from two anatomical sites, cheek abdomen, 80 individuals varying ages, developed microbiota profiles for both intrinsic photoaging provide an improved understanding age-dependent variation microbial composition. According...
The root rot mainly caused by Fusarium solani is a bottleneck in the cultivation of Panax notoginseng. In this study, we reported gene encoding plant cell wall structural protein, P. notoginseng proline-rich protein (PnPRPL1), whose transcription was upregulated F. and induced some hormone signals. PnPRPL1 recombinant significantly inhibited growth conidial germination pathogens. Downregulation RNA interference (RNAi) leaves increased susceptibility to solani, whereas overexpression tobacco...
Panax notoginseng (Burk) F.H. Chen is a rare and valuable Chinese herb, but root rot mainly caused by Fusarium solani severely affects the yield quality of P. herbal materials. In this study, we isolated 30 WRKY transcription factors (TFs), which were divided into three groups (I, II, III) on basis phylogenetic analysis. The expression levels 10 genes, including PnWRKY9, in roots increased response to methyl jasmonate (MeJA) treatment following F. infection. Additionally, PnWRKY9 was...
Panax notoginseng (Burk) F. H. Chen is a valuable traditional Chinese medicinal plant, but its commercial production seriously affected by root rot caused some pathogenic fungi, including Fusarium solani. Nevertheless, the genetic breeding for disease resistance of P. remains limited. The WRKY transcription factors have been revealed to play important roles in plant defense responses, which might provide an inspiration improvement notoginseng.In this study, regulatory mechanism factor...
High mobility group box 2 (HMGB2) is considered as a biomarker of poor prognosis in various cancers.This study aims to investigate the effect and mechanism HMGB2 gliomas.
Root rot, mainly caused by Fusarium oxysporum, is the most destructive disease affecting lily (Lilium spp.) production. The WRKY transcription factors (TFs) have important roles during plant immune responses. To clarify effects of TFs on defense responses to pathogens, a gene (LrWRKY2) was isolated from Lilium regale Wilson, which wild species highly resistant F. oxysporum. expression LrWRKY2, encodes nuclear protein, induced various hormones (methyl jasmonate, ethephon, salicylic acid, and...
MCM4 expression difference in HCC were analyzed from TCGA and GEO data verified by real-time PCR western blot. ROC curve was used to analyze the diagnostic value of AFP. Additionally, relationship between stage or nodal metastasis status grade age cohort with observed UALCAN website. The univariate multivariate Cox functional analyses done explore prognostic cohort.It found that significantly highly expressed tissues TCGA, GEO, experimental data. Furthermore, analysis showed superior be a...
WRKY transcription factors (TFs) play vital roles in plant growth and development, secondary metabolite synthesis, response to biotic abiotic stresses. In a previous transcriptome sequencing analysis of Lilium regale Wilson, we identified multiple TFs that respond exogenous methyl jasmonate treatment lily Fusarium wilt (Fusarium oxysporum).In the present study, TF LrWRKY3 was further analyzed reveal its function defense F. oxysporum. The protein localized cell nucleus, transgenic tobacco...
Gliomas are the most aggressive intracranial tumors accounting for vast majority of brain with very poor prognosis and overall survival (OS). Cancer-derived immunoglobulin G (cancer-IgG) has been found to be widely expressed in several malignancies such as breast cancer, colorectal lung cancer. Cancer-IgG could promote tumorigenesis progression. However, its role glioma not revealed yet.We mined open databases including Chinese Glioma Genome Atlas (CGGA), The Cancer (TCGA), Gene Expression...
Root rot of Panax notoginseng, a precious Chinese medicinal plant, seriously impacts its sustainable production. However, the molecular regulatory mechanisms employed by P. notoginseng against root pathogens, including Fusarium solani, are still unclear. In this study, PnMYB2 gene was isolated, and expression affected independent treatments with four signaling molecules (methyl jasmonate, ethephon, salicylic acid, hydrogen peroxide) as assessed quantitative real-time PCR. Moreover, level...
Glioma is the most frequent brain malignancy presenting very poor prognosis and high recurrence rate. Focal adhesion complexes play pivotal roles in cell migration act as hubs of several signaling pathways.We used bioinformatic databases (CGGA, TCGA, GEO) identified a focal adhesion-related differential gene expression (FADG) signature by uniCox LASSO regression analysis. We calculated risk score every patient using coefficient value each gene. Survival analysis, receiver operating...
Objective: The expression, prognosis, and related mechanisms of ANXA1 are investigated in glioma, with the objective to find potential therapeutic molecular targets for glioma. Methods: We analyzed gene expression using glioma-related databases, including Chinese Glioma Genome Atlas (CGGA) database, Cancer (TCGA) Gene Expression Omnibus (GEO) database. Moreover, we collected sample tissues corresponding paracancerous 23 glioma patients then conducted a Western blot experiment verify...
Background Aberrant DNA methylation of tumor suppressor genes is a common event in the development and progression gastric cancer (GC). Our previous study showed NDRG1, which could suppress cell invasion migration, was frequently down-regulated by its promoter GC. Purpose Methods To analyze relationship between expression NDRG1 methyltransferase (DNMT) family. We performed comprehensive comparison analysis using 407 patients including sequencing data GC from TCGA. Results GC, negatively...
Abstract Background: WRKY transcription factors (TFs) play vital roles in plant growth and development, secondary metabolite synthesis, response to biotic abiotic stresses. In a previous transcriptome sequencing analysis of Lilium regale Wilson, we identified multiple TFs that respond exogenous methyl jasmonate treatment lily Fusarium wilt ( oxysporum ). Results: the present study, TF LrWRKY3 was further analyzed reveal its function defense F. . The protein localized cell nucleus, transgenic...
Abstract Background Aberrant DNA methylation of tumor suppressor genes is a common event in the development and progression gastric cancer(GC). Our previous study showed NDRG1, which could suppress cell invasion migration, was frequently down-regulated by its promoter GC. Purpose Methods To analyze relationship between expression NDRG1 methyltransferase (DNMT) family. We performed comprehensive comparison analysis using 407 patients including sequencing data GC from TCGA. Results negatively...