Aims Papillary renal neoplasm with reverse polarity (PRNRP) is a newly documented rare tumour type. Its molecular pathological features have thus far been very little studied. Methods and results There were 13 PRNRP cases including 3 The Cancer Genome Atlas (TCGA) our 10 in this study. TCGA found by combined analysis of GATA3 mRNA expression levels digital slides from the papillary cell carcinoma project. KRAS codon 12 mutations identified three PRNRPs TCGA. Of cases, also discovered using...

Abstract Mitochondrial creatine kinase (Mt-CK) is a major determinant of cardiac energetic status and down-regulated in chronic heart failure, which may contribute to disease progression. We hypothesised that cardiomyocyte-specific overexpression Mt-CK would mitigate against these changes thereby preserve function. Male overexpressing mice (OE) WT littermates were subjected transverse aortic constriction (TAC) or sham surgery assessed by echocardiography at 0, 3 6 weeks alongside final LV...

Abstract To develop MRI-based radiomics model for predicting prostate cancer (PCa) in men with prostate-specific antigen (PSA) levels of 4–10 ng/mL, to compare the performance and PI-RADS v2.1, further verify predictive ability lesions different v2.1 score. 171 patients PSA ng/mL were divided into training (n = 119) testing 52) groups. score was assessed by two radiologists. All volumes interest segmented on T 2 -weighted imaging, diffusion weighted apparent coefficient sequences, from which...

Background Matrix metalloproteinase-9 (MMP-9) over-expression disrupts the blood-brain barrier (BBB) in ischemic brain. The retinoid X receptor agonist bexarotene suppresses MMP-9 expression endothelial cells and displays neuroprotective effects. Therefore, we hypothesized that may have a beneficial effect on I/R-induced BBB dysfunction. Methods A total of 180 rats were randomized into three groups (n = 60 each): (i) sham-operation group, (ii) cerebral ischemia-reperfusion (I/R) (iii) an...

Objective. The study aims to research the interventional effect and mechanism of astragaloside IV (Ast) synergizing with ferulic acid (FA) on idiopathic pulmonary fibrosis (IPF) induced by bleomycin in mice. Methods. mice were randomly divided into seven groups 10 each group, namely, a sham operation model miRNA-29b (miR-29) miR-29b negative control group (NC group), FA an Ast combination group. A mouse was established intratracheal instillation bleomycin. Samples collected after 28 days...

A classification system of renal cysts developed by Bosniak is based on computed tomography (CT) findings and has been applied to deal with the complex cystic masses. Magnetic resonance (MR) excellent soft-tissue resolution, it used further evaluate some lesions, especially those suspected containing soft tissue components hyperattenuating lesions seen CT. Compared CT, MR images may find additional information, which lead inconsistent classification. However, at present, there no consensus...

Sestrins (Sesns), a group of oxidative stress-related proteins, have been reported to be involved in various cardiovascular diseases, including aortic dissection and chronic heart failure. This study is aimed at investigating the level circulating Sesn1, Sesn2, Sesn3 hypertension patients.Plasma levels 400 hypertensive patients 100 normotensive subjects were detected using enzyme-linked immunosorbent assay (ELISA) kits. The divided into groups with grade I (n = 140), II 180), III 80)...

Air pollution is the main cause of respiratory diseases. Fine particulates with diameter below 2.5 μm can get into alveoli and then enter blood circulation through lung tissue ventilation function multiple systemic diseases especially This study investigated pathological mechanism lungs injury in rats induced by PM2.5 effect Chinese herbal medicine number 2 Feibi Recipe (number FBR) on injury. In this experiment, Wistar were used. Lungs was PM2.5. Number FBR used to treat rats. The result...

Number 2 Feibi Recipe (N2FBR) is a traditional Chinese medicine formula for treating idiopathic pulmonary fibrosis. N2FBR inhibits H2O2-mediated oxidative stress damage in alveolar epithelial cells by increasing autophagy, as we previously demonstrated. However, it unknown if similar mechanisms occur vivo. We established fibrosis model instilling bleomycin (BLM) from the airway to examine effects of on and investigate its probable mechanism this work. discovered that treatment effectively...

The overexpression of somatostatin receptor type 2 (SSTR2) is a unique characteristic gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs), which establishes the basis for both diagnosis and therapy. SSTR status can be evaluated by immunohistochemical staining (IHC) 68Ga-DOTATATE positron emission tomography/computed tomography (PET/CT) imaging. This study attempted to determine relationship between IHC PET/CT imaging explore optimal cutoff value reading.A total 100 GEP-NENs with...

Abstract Background Because of the lack reproducible brainstem ischemia models in rodents, temporal profile ischemic lesions after transient has not been evaluated intensively. Previously, we produced a model Mongolian gerbils. Here, showed ischemia. Results Brainstem was by occlusion bilateral vertebral arteries just before their entry into transverse foramina cervical vertebrae Animals were subjected to for 15 min, and then reperfused 0 d (just ischemia), 1 d, 3 7 (n = 4 each group)....

This paper mainly introduces a newly invented therapy which is called Target Treatment Injection of Micro-injury (TTIM) treating tuberculosis the lung. treatment injection micro-injury to use compound anti-TB medicine injecting into TB focus through skin lung according Computerized Tomography (CT) dimensionally, then aide with nutrition, movement, body and mental at same time cure disease once time. best way because it costs little, not much relapse can all kinds tuberculosis, take pleuritis...

Our study aimed to discuss the mechanism of pterostilbene in improving myocardial injury after percutaneous coronary intervention (PCI) through targeting miR-26a-5p. The cells were isolated from C57BL/6 mice. They frozen liquid nitrogen for reservation they passaged. cell transfection was performed with miR-26a-5p depressor or lipofectamine 3000. Ischemia-Reperfusion (I/R) model established. divided into several sets including control set, I/R imitative set and set. presentation GAPDH...

Falls in patients with cancer harbor potential for serious sequelae. Patients brain metastases (BrM) may be especially susceptible to falls but supporting investigations are lacking. We assessed the frequency, etiologies, risk factors, and sequelae of BrM using 2 data sources.We identified 42 648 111 utilizing Surveillance, Epidemiology, End Results (SEER)-Medicare (2008-2016) Brigham Women's Hospital/Dana-Farber Cancer Institute (BWH/DFCI) institutional (2015), respectively, characterized...

Coronavirus disease 2019 (COVID-19), which causes severe respiratory illness, was first reported in Wuhan, China. The etiology of the is a new novel coronavirus named acute syndrome 2 (SARS-CoV-2), to share same origin as SARS-CoV, causing public health events 2002. Unlike conquered early summer 2003, this virus still contagious widely and reached pandemic level. It can spread fast even if season's temperature raised. Here, we made model pneumonia human 229E (HCoV-229E) with damp-heat...

To initially explore traditional Chinese medicine patterns in a bleomycin-induced pulmonary fibrosis mouse model. Thirty-six C57BL/6 mice were divided by the random number table method (with 12 rats per group) into three groups: blank group, model and 2 Feibi recipe (FBR-2) group. The was established intratracheal instillation of bleomycin. FBR-2 group treated with for 4 weeks. Symptoms such as mental behavior, food/water intake, body weight, temperature, respiratory rate, tongue image...