Paul B. Shyn

ORCID: 0000-0003-0538-2151
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About
Contact & Profiles
Research Areas
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Pancreatic and Hepatic Oncology Research
  • Medical Imaging Techniques and Applications
  • Radiomics and Machine Learning in Medical Imaging
  • Cancer Genomics and Diagnostics
  • Renal cell carcinoma treatment
  • Radiation Dose and Imaging
  • MRI in cancer diagnosis
  • Medical Imaging and Pathology Studies
  • Lung Cancer Diagnosis and Treatment
  • Advanced Radiotherapy Techniques
  • Liver Disease Diagnosis and Treatment
  • Ultrasound in Clinical Applications
  • Radiology practices and education
  • Advanced X-ray and CT Imaging
  • Pleural and Pulmonary Diseases
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Renal and related cancers
  • Inflammatory Bowel Disease
  • Liver Disease and Transplantation
  • Adrenal and Paraganglionic Tumors
  • Cardiac, Anesthesia and Surgical Outcomes
  • Anesthesia and Sedative Agents
  • Microscopic Colitis
  • Gallbladder and Bile Duct Disorders

Brigham and Women's Hospital
2015-2024

Harvard University
2015-2024

Harvard Affiliated Emergency Medicine Residency
2021

Lemuel Shattuck Hospital
2017-2021

IGI Technologies (United States)
2021

Chestnut Hill College
2016-2020

Dana-Farber Cancer Institute
2018

Beth Israel Deaconess Medical Center
2012

Harvard University Press
2010

University of California San Francisco Medical Center
1992

Clinically relevant subtypes exist for pancreatic ductal adenocarcinoma (PDAC), but molecular characterization is not yet standard in clinical care. We implemented a biopsy protocol to perform time-sensitive whole-exome sequencing and RNA patients with advanced PDAC. Therapeutically genomic alterations were identified 48% (34/71) pathogenic/likely pathogenic germline 18% (13/71) of patients. Overall, 30% (21/71) enrolled experienced change management as result data. Twenty-six had and/or...

10.1158/2159-8290.cd-18-0275 article EN Cancer Discovery 2018-06-14

To determine the sensitivity and specificity of magnetic resonance (MR) imaging for depicting pancreatic small, functional islet cell tumors minimum number sequences expedient diagnosis.Twenty-eight patients clinically suspected to have underwent T1- T2-weighted spin-echo (SE) MR with without fat suppression, fast SE imaging, spoiled gradient-echo (GRE) before after injection gadopentetate dimeglumine. Sensitivity, specificity, best definitive diagnosis were determined.MR images depicted...

10.1148/radiology.214.2.r00fe32483 article EN Radiology 2000-02-01

To establish the feasibility of performing combined positron emission tomography (PET)/computed (CT)-guided biopsy abdominal masses by using previously acquired PET/CT images registered with intraprocedural CT images.In this HIPAA-compliant institutional review board-approved study, 14 patients underwent clinically indicated percutaneous (mean size, 3.3 cm; range, 1.2-5.0 cm) in liver (n = 6), presacral soft tissue 3), retroperitoneal lymph nodes 2), spleen and pancreas 1). obtained no more...

10.1148/radiol.10090931 article EN Radiology 2010-06-23

Percutaneous Image-Guided Cryoablation of Hepatic Tumors: Single-Center Experience With Intermediate to Long-Term OutcomesDaniel I. Glazer1, Servet Tatli2, Paul B. Shyn1, Mark G. Vangel3, Kemal Tuncali1 and Stuart Silverman1Audio Available | Share

10.2214/ajr.16.17582 article EN American Journal of Roentgenology 2017-09-27

Lung ultrasound (LUS) is an important imaging modality used by emergency physicians to assess pulmonary congestion at the patient bedside. B-line artifacts in LUS videos are key findings associated with congestion. Not only can interpretation of be challenging for novice operators, but visual quantification B-lines remains subject observer variability. In this work, we investigate strengths and weaknesses multiple deep learning approaches automated detection localization videos. We curate...

10.1109/jbhi.2023.3282596 article EN IEEE Journal of Biomedical and Health Informatics 2023-06-05

The purpose of this study was to determine which MRI features observed 24 hours after technically successful percutaneous cryoablation liver tumors predict subsequent local tumor progression and describe the evolution imaging findings cryoablation.Thirty-nine adult patients underwent imaging-guided 54 (hepatocellular carcinoma, 8; metastases, 46). pertaining tumor, ablation margin, surrounding treatment were assessed independently by two readers. Fisher exact or Wilcoxon rank sum tests...

10.2214/ajr.13.10747 article EN American Journal of Roentgenology 2014-02-20

Purpose: Advancements in and adoption of consumer virtual reality (VR) are currently being propelled by numerous upcoming devices such as the Oculus Rift. Although applications growing around entertainment field, wide-spread VR opens up potential for other that may have been unfeasible with past implementations VR. A environment provide an equal or larger screen area than what is provided use multiple conventional displays while remaining comparatively cheaper more portable making it...

10.1142/s2424905x16400031 article EN Journal of Medical Robotics Research 2016-03-01

Background Percutaneous ablation for cT1 renal cell carcinoma (RCC) remains underused, partially because of heterogeneous and limited long-term outcomes data assessing recent cryoablation methods. Purpose To report intermediate- to image-guided percutaneous RCC compare CT versus MRI guidance. Materials Methods This HIPAA-compliant retrospective single-institution study assessed patients who underwent solitary pathology-proven between August 2000 July 2017. Tumors (cT1a, n = 282; cT1b, 25;...

10.1148/radiol.2020200149 article EN Radiology 2020-07-07

BACKGROUND. To our knowledge, outcomes between percutaneous microwave ablation (MWA) and cryoablation of sarcoma lung metastases have not been compared. OBJECTIVE. The purpose this study was to compare technical success, complications, local tumor control, overall survival (OS) after MWA versus metastases. METHODS. This retrospective cohort included 27 patients (16 women, 11 men; median age, 64 years; Eastern Cooperative Oncology Group performance score, 0-2) who, from 2009 2021, underwent...

10.2214/ajr.21.26551 article EN American Journal of Roentgenology 2021-10-07

The purpose of this study was to evaluate the diagnostic efficacy low-dose, combined <sup>18</sup>F-FDG PET/CT enterography (PET/CTE), compared with CT (CTE) alone, in assessment patients Crohn disease. <b>Methods:</b> Thirteen disease were prospectively enrolled pilot and underwent abdominal–pelvic PET/CTE using neutral oral intravenous contrast medium. effective dose from 17.7 mSv for first 4 8.31 last 9 patients. Six surgical resection bowel, 7 colonoscopy biopsies within 27 d (mean, 12...

10.2967/jnumed.110.080796 article EN Journal of Nuclear Medicine 2010-11-15
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