A5027023236- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Organometallic Compounds Synthesis and Characterization
- Cardiac electrophysiology and arrhythmias
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- Advanced MRI Techniques and Applications
- Corrosion Behavior and Inhibition
- Erythrocyte Function and Pathophysiology
- Mesenchymal stem cell research
- Cardiovascular Function and Risk Factors
- Prenatal Screening and Diagnostics
- Synthesis and Characterization of Heterocyclic Compounds
- Marine Biology and Environmental Chemistry
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Wound Healing and Treatments
- Metal complexes synthesis and properties
- Potassium and Related Disorders
- Cardiac Imaging and Diagnostics
- Ultrasound and Hyperthermia Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Periodontal Regeneration and Treatments
- Metal and Thin Film Mechanics
- Synthesis of Tetrazole Derivatives
Fondazione Toscana Gabriele Monasterio
2013-2014
Istituto di Fisiologia Clinica
2013-2014
Istituto di Biomedicina e di Immunologia Molecolare Alberto Monroy
2008-2013
University of Siena
2011
National Research Council
2009
Due to the limited data available in literature, aim of this multi-centre study was prospectively compare thalassemia major (TM) patients efficacy combined deferiprone (DFP) and deferoxamine (DFO) regimen versus either DFP DFO monotherapy by cardiovascular magnetic resonance (CMR) over a follow up 18 months. Among first 1135 TM MIOT (Myocardial Iron Overload Thalassemia) network, we evaluated those who had received (DFO + DFP, N=51) or (N=39) (N=74) monotherapies between two CMR scans....
Summary The relationship between diabetes mellitus ( DM ) and cardiac complications has never been systematically studied in thalassaemia major TM ). We evaluated a large retrospective historical cohort of to determine whether is associated with higher risk heart complications. compared 86 patients affected by 709 without consecutively included the Myocardial Iron Overload Thalassaemia database where clinical/instrumental data are recorded from birth first cardiovascular magnetic resonance...
Summary The age at which it is necessary to start Cardiovascular Magnetic Resonance ( CMR ) T2* screening in thalassaemia major TM still uncertain. To clarify this point, we evaluated the prevalence of myocardial iron overload MIO ), function and fibrosis by patients younger than 10 years. We retrospectively selected 35 enrolled Myocardial Iron Overload Thalassaemia network. was measured multislice multiecho technique. Biventricular parameters were cine images. detect fibrosis, late...
Purpose: Cardiovascular Magnetic Resonance (CMR) plays a key role in the management of thalassemia major (TM), allowing to assess myocardial iron overload (MIO), biventricular function, atrial dimensions, and fibrosis. We determined predictive value CMR parameters for heart failure (HF) arrhythmias TM. Methods: followed prospectively 537 patients enrolled MIOT network. Fifty were excluded because cardiac complication was present at time first CMR. All variables associated with outcome...
Background Thalassemia intermedia (TI) patients were shown to have significantly higher cardiac output and volumes with respect thalassemia major (TM) patients. So, compare biventricular parameters in TI established ranges from TM may be misleading. The aim of this study was establish the for normal ejection fraction (EF) left ventricular (LV) mass assessed by cardiovascular magnetic resonance (CMR) TI.
Purpose: Sickle-thalassemia is an inherited hemoglobin disorder resulting from the combined heterozygosity for sickle-cell and β-thalassemia genes. Myocardial iron overload in patients with sickle-thalassemia has been poorly studied; however, a report shown no evidence of cardiac small group (n=10) multitransfused Arab patients. The current study aims to further evaluate larger Italian using T2* multislice approach explore its correlation transfusions, age sex. Methods: Fifty-nine (29 males,...
Purpose: Cardiovascular Magnetic Resonance (CMR) by late gadolinium enhancement (LGE) allows to detect myocardial fibrosis. Myocardial fibrosis was shown be a relative common finding in Italian thalassemia major (TM) patients mainly related HCV infection, but specific studies involving only pediatric are not available.
Background Myocardial iron overload assessment by multislice multiecho T2* technique is used in the clinical management of thalassemia major (TM) patients. Signal decay curves are extracted from 16 left ventricular (LV) segments and fitting these to a mono-exponential model provides corresponding values. In patients with severe cardiac overload, where signal will quickly becoming comparable image noise, manual truncation excluding later echo times (TEs) adopted. this study an automatic...
Purpose: We investigated myocardial iron overload (MIO), biventricular parameters and fibrosis assessed by cardiovascular magnetic resonance (CMR) in a large cohort of thalassemia intermedia (TI) patients categorized different transfusional regimens. This survey is particularly significant considering the debate on opportunity to transfuse TI patients. Methods: studied retrospectively 252 adult (119 females, 39±10 yrs) enrolled MIOT Network. MIO was multislice multiecho T2* approach. Cine...
Purpose: Movement abnormalities of the left ventricle (LV) have been reported in thalassemia major patients. We investigated relationships between movement and myocardial iron overload (MIO) fibrosis, detected by cardiovascular magnetic resonance (CMR).
Purpose: Myocardial iron overload assessment by multislice multiecho T2* technique is used in the clinical management of thalassemia major (TM) patients. Signal decay curves are extracted from 16 left ventricular (LV) segments and fitting these to a mono-exponential model provides corresponding values. In patients with severe cardiac overload, where signal will quickly becoming comparable image noise, manual truncation excluding later echo times (TEs) adopted. this study an automatic method...
Purpose: Thalassemia intermedia (TI) patients have significantly higher cardiac output and volumes with respect to thalassemia major patients. This study aimed establish the ranges for normal biventricular ejection fraction (EF) left ventricular (LV) mass assessed by cardiovascular magnetic resonance (CMR) in TI. Methods: Among 294 adult TI enrolled MIOT network, we selected 68 no known risk factors or history of disease, electrocardiogram, myocardial iron overload fibrosis. Biventricular...
Objectives: Movement abnormalities of the left ventricle (LV) have been reported in thalassemia major (TM) patients. can be detected through a qualitative analysis cine CMR images. Moreover, is gold standard technique for evaluation myocardial iron overload (MIO), biventricular global systolic function and fibrosis. The aim this study was to investigate relationship between movement MIO, ventricular Methods: (1.5T) performed 1092 TM patients (537 male; 30.6 ± 8.5 years) enrolled Myocardial...
Objectives: Myocardial iron overload (MIO) assessment by multislice multiecho T2* technique is used in the clinical management of thalassemia major patients. Signal decay curves are extracted from 16 left ventricular (LV) segments and fitting these to a mono-exponential model provides corresponding values. In patients with severe MIO signal decays quickly becoming comparable image noise, so manual truncation excluding later echo times (TEs) adopted. this study an automatic method avoiding...
Objectives: Cardiac complications are the main cause of death in thalassemia major (TM) patients. CMR plays a key role management TM, allowing to assess cardiac iron burden, biventricular dimension and function, atrial dimensions, myocardial fibrosis. We aimed determine predictive value parameters for heart failure (HF) arrhythmias TM. Methods: followed prospectively 537 white TM patients enrolled MIOT network. Fifty were excluded from analysis because complication was present at time first...
Objectives: Thalassemia intermedia (TI) patients were shown to have significantly higher cardiac output and volumes with respect thalassemia major (TM) patients. So, compare biventricular parameters in TI established ranges from TM may be misleading. The aim of this study was establish the for normal ejection fraction (EF) left ventricular (LV) mass assessed by cardiovascular magnetic resonance (CMR) TI. Materials: Among 294 > 18 years age enrolled Myocardial Iron Overload (MIOT) network who...
Objectives: Little is known about cardiac involvement in thalassemia intermedia (TI) using cardiovascular magnetic resonance (CMR), which the unique technique for non invasive evaluation of iron overload, myocardial function and fibrosis. Our aim was to investigate overload (MIO), biventricular parameters, fibrosis a large cohort TI categorized different transfusional regimens. Methods: We studied retrospectively 252 adult patients (119 females, 39.5 ± 10.4 years) enrolled Myocardial Iron...
Objectives: Sickle-thalassemia is an inherited hemoglobin disorder resulting from the combined heterozygosity for sickle-cell and β-thalassemia genes. Myocardial iron overload in patients with sickle-thalassemia has been poorly studied; however, a report shown no evidence of cardiac small group (n = 10) multitransfused Arab patients. The current study aims to further evaluate larger Italian using T2* multislice approach explore its correlation transfusions, age sex. Methods: Fifty-nine (29...
Objectives: CMR by late gadolinium enhancement (LGE) allows to detect myocardial fibrosis. Myocardial fibrosis was shown be a relative common finding in large cohort of Italian thalassemia major (TM) patients mainly related HCV infection, but specific studies involving only pediatric are not available. This study investigated the prevalence and clinical-instrumental correlates TM patients. Methods: We studied retrospectively 76 with (44 boys, 4.2 -17.9 years old, mean age 13.6 ± 3.4 years)...