A5101937975- Epigenetics and DNA Methylation
- Neurological Disease Mechanisms and Treatments
- Inflammasome and immune disorders
- Histone Deacetylase Inhibitors Research
- Photoreceptor and optogenetics research
- Endoplasmic Reticulum Stress and Disease
- Chronic Myeloid Leukemia Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Bat Biology and Ecology Studies
- Selenium in Biological Systems
- Adipose Tissue and Metabolism
- Advanced Glycation End Products research
- Sex and Gender in Healthcare
- Pharmacological Effects of Natural Compounds
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Photonic and Optical Devices
- Photochromic and Fluorescence Chemistry
- interferon and immune responses
- Cryospheric studies and observations
- Polydiacetylene-based materials and applications
- Orthopaedic implants and arthroplasty
- Immune cells in cancer
- Hydrogen's biological and therapeutic effects
- Alkaline Phosphatase Research Studies
Liaoning University of Traditional Chinese Medicine
2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Air Force Medical University
2019-2024
Xijing Hospital
2023-2024
Heidelberg University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
University of Chinese Academy of Sciences
2021
Zhejiang University of Technology
2019
Wenzhou Medical University
2015
Abstract The realization of high-quality (Q) resonators regardless the underpinning material platforms has been a ceaseless pursuit, because high-Q provide an extreme environment for confining light to enable observations many nonlinear optical phenomenon with high efficiencies. Here, photonic microresonators mean Q factor 6.75 × 10 6 were demonstrated on 4H-silicon-carbide-on-insulator (4H-SiCOI) platform, as determined by statistical analysis tens resonances. Using these devices, broadband...
As an emerging treatment strategy for triple-negative breast cancer (TNBC), immunotherapy acts in part by inducing ferroptosis. Recent studies have shown that protein arginine methyltransferase 5 (PRMT5) has distinct roles among multiple cancers modulating the tumor microenvironment. However, role of PRMT5 during ferroptosis, especially TNBC immunotherapy, is unclear.PRMT5 expression was measured IHC (immunohistochemistry) staining. To explore function ferroptosis inducers and functional...
Oxidative stress (OS) is an essential factor in the pathogenesis of branch retinal vein occlusion (BRVO). Studies have demonstrated role hydrogen gas regulation OS. This study was designed to evaluate efficacy on BRVO rat model.Twenty-four rats were randomly divided into two groups: (H) group (42% H2, 21% O2, 37% N2) and model (M) (21% 79% N2). Rats H inhaled for 8 h every day up 30 d post-occlusion. Twelve age-matched healthy served as control (C) group. Retinal function morphology detected...
Background Cerebral ischemia/reperfusion injury (CIRI) is still a complicated disease with high fatality rates worldwide. Transmembrane Protein 79 (TMEM79) regulates inflammation and oxidative stress in some other diseases.
Fibroblast growth factor 2 (FGF2) plays a critical role in tumorigenesis and progression of solid tumor is upregulated gastric carcinoma serum. Therefore, it regarded as potential therapeutic target human cancer. Suppression bioactivities FGF2 may contribute to cancer therapy. Herein, we obtained novel FGF2-binding peptide derivative (named P32), which originated from previously isolated P7 with poor stability. We proved that P32, had half-life plasma up 12 h, enhanced stability exerted...
Bats are the only mammals capable of self-powered flight using wings. Critical adaptations for their include a pair dramatically elongated hands (forelimb digits II–V) with broad wing membranes. Although it has been studied over ten years, molecular mechanism bat evolution was still uncertain before 2014. Here we reviewed recently significant studies on this topic, which made great progress knowledge formation. Thousands differentially expressed genes and regulatory elements associated limb...
Abstract Brillouin spectroscopy is commonly used to study the acoustic properties of materials. Here we explored its feasibility in studying photoinduced isomerization azobenzene. The azobenzene changes solution elastic modulus, and scattering sensitive these changes. In this study, experimentally demonstrated photoswitching DMSO using our home-made virtually imaged phased array-based high-resolution optical spectrometer, confirmed results by ultraviolet–visible spectrophotometry. Remarkable...
Molecular glue degraders (MGDs) are proximity-inducing agents that mediate the cooperative interaction between a target protein and an E3 ligase, introducing additional layer of specificity beyond afforded by traditional small molecules. Historically, molecular glues stabilize protein-protein interactions were often discovered serendipitously. In this study, we leveraged reprogramming potential cereblon (CRBN)-based ligands conducted CRBN-dependent proliferation screen to identify CRBN-based...
To observe the effect of eye-acupuncture on antioxidant function axis：System xc(-)-glutathione-glutathione peroxidase 4 (System xc［-］-GSH-GPX4) in cortical tissue ischemic penumbra acute cerebral ischemia-reperfusion injury (CIRI) rats, so as to explore its underlying mechanism improvement CIRI by ameliorating ferroptosis neurons via axis.