A5074944716- Galectins and Cancer Biology
- Antimicrobial Peptides and Activities
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Pancreatitis Pathology and Treatment
- Immune Response and Inflammation
- Macrophage Migration Inhibitory Factor
- Invertebrate Immune Response Mechanisms
- Eosinophilic Esophagitis
- Neurobiology and Insect Physiology Research
- Angiogenesis and VEGF in Cancer
- Cytokine Signaling Pathways and Interactions
- Synthesis and biological activity
- Clinical Nutrition and Gastroenterology
- S100 Proteins and Annexins
- Tryptophan and brain disorders
- Gastrointestinal disorders and treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Diabetes and associated disorders
- Immune cells in cancer
- Organ Transplantation Techniques and Outcomes
- Lymphatic System and Diseases
- Free Radicals and Antioxidants
- Polydiacetylene-based materials and applications
- Crystallization and Solubility Studies
University of Kragujevac
2014-2024
University of Vienna
2023
University of California, Davis
2012
The role of IL‐33/ST2 pathway in antitumor immunity is unclear. Using 4T1 breast cancer model we demonstrate time‐dependent increase endogenous IL‐33 at both the mRNA and protein levels primary tumors metastatic lungs during progression. Administration accelerated tumor growth development lung liver metastases, which was associated with increased intratumoral accumulation CD11b + Gr‐1 TGF‐β1 myeloid‐derived suppressor cells (MDSCs) that expressed IL‐13α1R, IL‐13‐producing Lin − Sca‐1 ST2...
Obesity-induced diabetes is associated with low-grade inflammation in adipose tissue and macrophage infiltration of islets. We show that ablation galectin-3 (Gal-3), a galactoside-binding lectin, accelerates high-fat diet–induced obesity diabetes. Obese LGALS3−/− mice have increased body weight, amount total visceral (VAT), fasting blood glucose insulin levels, homeostasis model assessment resistance, markers systemic compared diet-matched wild-type (WT) animals. VAT obese exhibited...
The importance of Galectin-3 (Gal-3) in obesity-associated liver pathology is incompletely defined. To dissect the role Gal-3 fibrotic nonalcoholic steatohepatitis (NASH), Gal-3-deficient (LGALS3−/−) and wild-type (LGALS3+/+) C57Bl/6 mice were placed on an obesogenic high fat diet (HFD, 60% kcal fat) or standard chow for 12 24 wks. Compared to WT mice, HFD-fed LGALS3−/− developed, addition increased visceral adiposity diabetes, marked steatosis, which was accompanied with higher expression...
Plasticin-L1 (GLVNGLLSSVLGGGQGGGGLLGGIL) is a conformationally flexible glycine/leucine-rich peptide originally isolated from norepinephrine-stimulated skin secretions of the South-American Santa Fe frog Leptodactylus laticeps (Leptodactylidae). A nuclear magnetic resonance/molecular dynamics characterization plasticin-L1 in presence dodecylphosphocholine (DPC) and DPC/sodium dodecylsulphate micelles as membrane-mimetic models showed that has affinity for both neutral anionic membranes. The...
Older adults lack of proper physical activity which is often accompanied by vitamin D deficiency. Those factors are known to contribute health issues in the later years life. The main goal this intervention study was investigate effect different supplementation strategies for 4 weeks solely or combined with a 10-week strength training program on chromosomal stability peripheral blood mononuclear cells community-dwelling older people. One hundred women and men (65-85 years) received either D3...
The cells of the innate and adaptive immune systems have been implicated in development obesity-induced metaflammation metabolic disorders including type 2 diabetes. Galectin-3, a β-galactoside-binding lectin, modulates immune/inflammatory responses specifically binds to advanced glycation end products (AGE), modified lipoproteins, endotoxin. In recently published study we demonstrate proinflammatory changes visceral adipose tissue pancreatic islets galectin-3-deficient mice fed high-fat...
Angiogenesis and lymphangiogenesis in PTC 429Angiogenesis are fundamental processes for tumor progression represent important characteristics of the microenvironment. 3While angiogenesis promotes growth metastasis, 4 provides an alternative route cancer cell dissemination to lymph nodes. 5 The frequently used method quantifying INTROduCTIONThe most common type thyroid malignancy is papillary carcinoma (PTC).PTC has a favorable prognostic outcome usually occurs several histological variants....
Diabetic patients have higher incidence and mortality of cancer. Recent study revealed that hyperglycemia-induced oxidative stress is involved in the acceleration tumor metastasis. We used model high-dose streptozotocin-induced diabetes to investigate its effect on growth modulation antitumor immune response 4T1 murine breast cancer BALB/c mice. Diabetes accelerated appearance, weight, which was associated with decreased NK cells cytotoxicity against vitro reduced frequencies systemic...
Sepsis is a life-threatening disease mediated by profound disturbances in systemic inflammatory response to infection. IL-33 multifunctional regulator of numerous aspects innate and adaptive immune response. The aim this article was further evaluate the role receptor (ST2) different pathways immunity during early polymicrobial sepsis. Polymicrobial sepsis induced using cecal ligation puncture (CLP) model ST2 deficient (ST2−/−) wild type BALB/c mice. Peritoneal spleen cells were isolated for...
// Milena Jurisevic 1, 2 , Aleksandar Arsenijevic 1 Jelena Pantic Nevena Gajovic Milovanovic 3 Marija Poljarevic 4 Tibor Sabo Danilo Vojvodic 5 Gordana D. Radosavljevic and Nebojsa Center for Molecular Medicine Stem Cell Research, Faculty of Medical Sciences, University Kragujevac, Serbia Department Pharmacy, Histology Embryology, Chemistry, Belgrade, Institute Medicine, Military Academy, Correspondence to: Radosavljevic, email: perun.gr@gmail.com Jurisevic, milena.jurisevic13@gmail.com...
ABSTRACT Acute pancreatitis is characterized by autodigestion of pancreatic cells followed acute inflammation leading to pathology and death. In experimental pancreatitis, acinar infiltrating macrophages express Galectin‐3 but its role in this disease unknown. Therefore, we studied using deficient mice. Deletion prolonged the survival mice, led attenuation histopathology, decreased infiltration mononuclear neutrophils that TLR‐4, particular, pro‐inflammatory N1 neutrophils. TLR‐4 are also...
Abstract Galectin-3, a unique chimaera-type member of the lectin family, displays wide range activities. This versatile molecule is involved in fundamental biological processes, including cell proliferation, cell-cell adhesion, apoptosis and immune responses. review aimed at providing general overview actions diverse effects Galectin-3 many pathological conditions, with specific focus on autoimmunity, inflammation tumour progression. We report herein that exerts deleterious functions...
Aim: We investigated the antitumor effects of zinc(II) complex with S-propyl thiosalicylic acid [Zn(S-pr-thiosal)2] in 4T1 murine breast cancer model. Results: The Zn(S-pr-thiosal)2 reduced primary tumor growth vivo and induced cell apoptosis. disrupted balance between pro- antiapoptotic Bcl-2 family members cells G1/S cycle arrest. increased percentage p16, p21 p27 positive cells. There was a significantly decrease expression STAT3 its targets c-Myc cyclin D3 treated thus contributing to...
Many studies so far have shown that antipsychotic therapy may an effect on the development of metabolic syndrome in patients diagnosed with schizophrenia. Our goal was to determine whether our respondents are at risk for developing and who is more predisposed it.In a stable phase, 60 schizophrenia were equally divided into three groups according drug (risperidone, clozapine, aripiprazole monotherapy). Control group had 20 healthy examinees. Patients evaluated first using The Positive...