A5002743258- Thyroid Disorders and Treatments
- Diabetes Management and Research
- Pancreatic function and diabetes
- interferon and immune responses
- Connective tissue disorders research
- Congenital Diaphragmatic Hernia Studies
- Hypothalamic control of reproductive hormones
- Parathyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Growth Hormone and Insulin-like Growth Factors
- Diabetes and associated disorders
- Vitamin D Research Studies
- Ovarian function and disorders
- Neonatal Health and Biochemistry
- Dermatological and Skeletal Disorders
- Gastrointestinal motility and disorders
- MicroRNA in disease regulation
- Heterotopic Ossification and Related Conditions
- Salivary Gland Disorders and Functions
- Cancer-related molecular mechanisms research
- Electrolyte and hormonal disorders
- Congenital gastrointestinal and neural anomalies
- Reproductive Biology and Fertility
- Testicular diseases and treatments
- Plant Reproductive Biology
Ümraniye Eğitim ve Araştırma Hastanesi
2018-2022
Sağlık Bilimleri Üniversitesi
2019-2022
Kocaeli Üniversitesi
2016-2019
Istanbul University
2013-2018
Center for Rheumatology
2013
Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders and when compared to vast knowledge pertaining adults with IBS, very little known about IBS in children adolescents. We aimed explore prevalence identify symptoms contributing factors also examine efficacy trimebutine maleate adolescents.The study involved 345 adolescents (4-18 years) parents were requested fill a questionnaire, Rome III criteria was used diagnose IBS. To exclude organic disease,...
The causes of gonadotropin-independent precocious puberty are diverse, and often have overlapping clinical biochemical features. With the exception congenital adrenal hyperplasia (CAH), disorders that cause (GIPP) uncommon. literature is devoid any large-scale studies on etiologic distribution GIPP. aim this study was to determine frequency each etiology in a cohort patients with GIPP (excluding those CAH), evaluate laboratory features these patients. This multicenter, nationwide web-based...
To assess the incidence of type 1 diabetes mellitus (T1DM) in children under 18 years age northwest region Turkey during 2013-2015.
To determine the adherence of pediatricians to nationwide 'Vitamin D Prophylaxis Program' and evaluate their attitudes about vitamin intake. The study was conducted using Turkish National Pediatrics Association network. were asked respond an online questionnaire that included five questions on 'What dose they recommend for supplementation?', 'At what age start 'Supplementation method', 'Clichés truths D', 'High-dose therapy indications'. Responses 167 evaluated in this study. 75.5% indicated...
Premature thelarche (PT) is defined as isolated breast development in girls before eight years of age. Gonadotropin-releasing hormone (GnRH) stimulation test sometimes used to distinguish between PT and central precocious puberty (CPP), although the interpretation at early ages challenging. The objective this study was determine follicle stimulating (FSH) luteinizing (LH) responses GnRH with below 3
Abstract Background Thyroid dysfunction is the most common hormonal abnormality in obesity. It should actually be considered as an adaptation response to fat excess. However, little has been reported on morphology of thyroid gland, and no data regarding relationship between gland changes metabolic parameters are available obese adolescents. Objective The study aimed evaluate frequency non-autoimmune thyroiditis adolescents compare status patients with or without thyroiditis. Methods A total...
To describe the baseline clinical and laboratory findings treatment modalities of 367 children adolescents diagnosed with Type 2 diabetes in various paediatric endocrinology centres Turkey.A standard questionnaire regarding characteristics at onset was uploaded to an online national database system. Data for (aged 6-18 years) newly 37 different were analysed.After exclusion a BMI Z-score < 1 SD, those genetic syndromes associated diabetes, whose C-peptide and/or insulin levels not available,...
Late neonatal hypocalcemia (LNH) is a common metabolic problem associated with hypoparathyroidism, high phosphate intake and vitamin D deficiency, often presenting seizures. In this cross-sectional study, we aimed to evaluate the role of deficiency in LNH Turkey describe characteristics affected newborns.Conducted design participation 61 centers from December 2015 2016, study included term neonates (n=96) their mothers (n=93). Data were registered on FAVOR Web Registry System. Serum samples...
Abstract Neonatal diabetes is a rare form of monogenic characterised by persistent hyperglycaemia during the first 6–9 months age. About half cases neonatal are transient forms resulting from mutations in genes imprinted region chromosome 6q24 and other permanent forms. Activating potassium ATP (K
Leptin resistance is one of the important causes obesity in children. Besides known leptin like mutations and receptor genes, overexpression SOCS3 arcuate nucleus a potential cause resistance. We aimed to determine effects circulating miRNAs on obese children by targeting pathway.miRNAs potentially were determined using online target prediction databases. Polymorphisms miRNA sequences genome browsers. expression levels (n=35) non-obese (n=30) qPCR method, genotyping performed real-time PCR...
Generalized arterial calcification of infancy (GACI) is a rare autosomal-recessive disorder, characterized by the internal elastic lamina, fibrotic myointimal proliferation muscular arteries and resultant stenosis.Treatment with bisphosphonates has been proposed as means reducing calcifications in GACI patients, although there no formalized treatment approach.The case reported here was patient severe diagnosed at three months age who had response to bisphosphonate treatment, but clinically...
What is already known on this topic?Late neonatal hypocalcemia occurs after the first 72 hours and most common causes include excessive phosphate intake, hypomagnesemia, hypoparathyroidism, vitamin D deficiency. study adds?Maternal deficiency was found to be cause of late in our study.Due immaturity regulating factors parathormone calcium, serum iPTH levels may not reach expected phosphorus remain high deficient neonates, posing a diagnostic dilemma by mimicking primary hypoparathyroidism.
<h3>Background</h3> Primary Sjögren's syndrome (pSjS) is a chronic autoimmune disease primarily involving the exocrine glands. The clinical picture of pSjS ranges from exocrinopathy to systemic disease. Environmental and hormonal factors, such as vitamin-D may play role in pathogenic process expression activity. literature investigating relationship between vitamin D limited. <h3>Objectives</h3> We aimed evaluate levels its association with activity pSjS. <h3>Methods</h3> This study included...
What is already known on this topic?Generalized arterial calcification of infancy (GACI) a rare disease that associated with high mortality rate owing to the development severe hypertension and cardiovascular complications.GACI can begin in utero during third trimester, 50% children GACI present well-developed large calcifications within first week life.Although there no definitive treatment, it claimed patients treated bisphosphonates have better survival rates.In contrast, not were also...