A5023658478- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease and Transplantation
- Pregnancy and Medication Impact
- Systemic Lupus Erythematosus Research
- Celiac Disease Research and Management
- Cancer Immunotherapy and Biomarkers
- Cancer therapeutics and mechanisms
- Colorectal Cancer Treatments and Studies
- Pediatric health and respiratory diseases
- Pharmacological Effects of Natural Compounds
- Dental Education, Practice, Research
- Microscopic Colitis
- Dental Health and Care Utilization
- IgG4-Related and Inflammatory Diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Hepatitis B Virus Studies
- Epilepsy research and treatment
Aarhus University Hospital
2013-2025
Regional Hospital Horsens
2020-2025
ERN GUARD-Heart
2025
ERN RARE-LIVER
2025
University of Nottingham
2020-2024
There are few population-based studies of the incidence and mortality autoimmune hepatitis. The burden disease how it has changed over time have not been fully explored. We conducted a cohort study on hepatitis in England, 1997-2015.From Clinical Practice Research Datalink we included 882 patients diagnosed with 1997-2015. were followed through 2015, calculated sex- age-standardized prevalence examined variation by sex, age, calendar year, geographical region socioeconomic status, rate...
Background: Impaired health-related quality of life (HRQoL) contributes to the overall disease burden in autoimmune hepatitis (AIH). This study aimed evaluate HRQoL people with AIH and identify potentially modifiable factors associated impaired using validated patient-reported outcome measures. Methods: Adult patients diagnosed at 12 European centers were enrolled this prospective, cross-sectional from July 2020-June 2023. was assessed Physical Component Score (PCS) Mental (MCS) 12-item...
Summary Background Many patients with autoimmune hepatitis are women of fertile age. Some concerns these related to pregnancy. Aim To conduct a nationwide study on risk miscarriage, birth rate, and outcomes in hepatitis. Methods From Danish healthcare registries, 1994‐2015, we identified 179 births 103 hepatitis, 70 which were first‐time singleton births, 1623 1051 age‐matched (population controls), 662 births. We calculated the miscarriage rate after diagnosis controls. used logistic...
Background There is limited evidence to support the belief that benzodiazepines increase cirrhosis patients’ risk of hepatic encephalopathy (HE). Objective We aimed examine association between benzodiazepine use and HE development in patients. Methods used data on 865 patients with ascites from three trials study effect first-time HE. For each patient, we classified periods by number days since initiation. Cox regression compare current users vs. non-users adjusting for confounders. Results...
INTRODUCTION: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease and as such may increase the risk of cancer. We examined cancer risks in nationwide cohort patients with AIH. METHODS: This study was based on Danish healthcare registries. identified all persons diagnosed AIH between 1994 2018. included 1805 16,617 age- sex-matched population controls. estimated cumulative cancers ratios (RRs) Within AIH, we impact immunosuppressive treatment (IST) cirrhosis risks. RESULTS: The...
Abstract Background & Aims It is widely accepted that patients with autoimmune hepatitis have an increased prevalence of extrahepatic diseases. believed the patients' relatives share this trait, but it has not been studied in a satisfactory setting. We conducted nationwide registry‐based cohort study on issue. Methods From Danish healthcare registries 1994‐2015, we included 2745 hepatitis, 17 812 their first‐ and second‐degree 27 450 general population controls matched for sex age....
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease associated with an increased prevalence of extrahepatic autoimmune diseases and mortality compared the general population. The contribution to has not been clarified. Our aim was determine effect on in AIH patients.This nationwide register-based cohort study included all Danish patients diagnosed between 1995 2019. We examined presence without diseases. adjusted our analysis for age, sex, calendar year diagnosis, cirrhosis,...
Purpose: Smoking is a risk factor for some autoimmune diseases, but its association with hepatitis remains unknown. We conducted population-based matched case–control study to examine the between tobacco smoking and of in England. Patients Methods: From Clinical Practice Research Datalink linked Hospital Episode Statistics, 2005– 2017, we included 987 cases diagnosed after age 18 years up 10 frequency-matched population controls per case. used multiple logistic regression estimate odds ratio...
Immunotherapy-induced hepatitis is a well-known and relatively common side effect of immune checkpoint inhibitors. It usually mild to moderate responds well corticosteroids with full recovery. However, in rare cases, severe liver injury may develop, leading fulminant failure. In this case report, we present acute failure fatal outcome despite adequate treatment 67-year-old male following combination therapy carboplatin, pemetrexed, pembrolizumab for metastatic lung cancer.