A5040620463- Gut microbiota and health
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Birth, Development, and Health
- Health, psychology, and well-being
- Stress Responses and Cortisol
- MicroRNA in disease regulation
- Telomeres, Telomerase, and Senescence
- Salivary Gland Disorders and Functions
- Child Abuse and Trauma
- Oral microbiology and periodontitis research
- Genetic Associations and Epidemiology
- Anesthesia and Neurotoxicity Research
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Clostridium difficile and Clostridium perfringens research
- Identity, Memory, and Therapy
- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Health
- Memory and Neural Mechanisms
- Circular RNAs in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Infant Health and Development
Universidad Complutense de Madrid
2022-2024
Centro de Investigación Biomédica en Red de Salud Mental
2022-2024
Research Institute Hospital 12 de Octubre
2023-2024
Universidad de Oviedo
2024
Instituto de Salud Carlos III
2022-2024
South African Medical Research Council
2015-2023
Stellenbosch University
2012-2023
Versar (United States)
2017
Lowry Memorial College & Group of Institutions
2017
South African Tuberculosis Vaccine Initiative
2016
Inadequate immunoregulation and elevated inflammation may be risk factors for posttraumatic stress disorder (PTSD), microbial inputs are important determinants of immunoregulation; however, the association between gut microbiota PTSD is unknown. This study investigated microbiome in a South African sample PTSD-affected individuals trauma-exposed (TE) controls to identify potential differences diversity or community structure.The Clinician-Administered Scale DSM-5 was used diagnose according...
The prevalence of anxiety and depression soared following the COVID-19 pandemic. To effectively treat these conditions, a comprehensive understanding all etiological factors is needed. This study investigated fecal microbial features associated with mental health outcomes (symptoms anxiety, depression, or posttraumatic stress disorder (PTSD)) in Spanish cohort aftermath Microbial communities from stool samples were profiled 198 individuals who completed validated, self-report questionnaires....
Background: Women are at an increased risk of depression and other mental health problems following rape. Various etiological factors for depression, including predisposing genetic factors, have been identified. Telomeres repetitive nucleoprotein structures located chromosomal ends that protect them from premature degradation. reduce in length with each cell division, resulting cellular senescence apoptosis. Methods: Relative quantification telomeric repeats using qPCR was performed to...
This study was aimed at elucidating the common sequence variation present in CYP2C19 gene within South African Xhosa population and comparing it with Cape Mixed Ancestry (CMA) for possible future pharmacogenetic applications.Common identified through resequencing of 15 individuals. The detected variants were prioritized genotyping an additional 85 75 CMA individuals, while 5 -upstream analyzed using dual luciferase reporter assays.Resequencing revealed 30 variants, including novel CYP2C19*27...
Obsessive-compulsive disorder (OCD) is a psychiatric illness that significantly impacts affected patients and available treatments yield suboptimal therapeutic response. Recently, the role of gut-brain axis (GBA) in has emerged as potential target for exploration. However, studies concerning GBA OCD are limited. To investigate whether naturally occurring obsessive-compulsive-like phenotype rodent model, large nest building deer mice, associated with perturbations gut microbiome, we...
The neuropathogenesis of the human immunodeficiency virus (HIV) may manifest as various neurocognitive impairments (NCI). HIV-positive individuals also have significantly shorter telomere length (TL) in peripheral blood mononuclear cells (PBMCs) and CD8+ T compared to HIV-negative individuals. Additionally, reduced TL has been found be associated with chronic psychological stress. This study focused on effects HIV-infection stress childhood trauma length, investigated whether leukocyte...
Alterations in brain-derived neurotrophic factor (BDNF) expression and release may play a role the pathogenesis of post-traumatic stress disorder (PTSD).This study evaluated road traffic accident (RTA) survivors to determine whether PTSD trauma-related factors were associated with plasma BDNF levels Val66Met carrier status following RTA exposure.One hundred twenty-three (mean age 33.2 years, SD = 10.6 years; 56.9% male) assessed 10 (SD 4.9) days after exposure. Acute (ASD), as Stress...
Appetitive aggression is a sub-category of instrumental aggression, characterised by the primary intrinsic enjoyment aggressive activity. Aggression heritable, and serotonergic monoaminergic neurotransmitter systems have been found to contribute underlying molecular mechanisms. The aim this study was investigate role that genetic variants in serotonin transporter (SLC6A4) monoamine oxidase A (MAOA) genes play aetiology appetitive South African Xhosa males (n = 290). SLC6A4 5-HTTLPR, rs25531,...
The role of the oral microbiome in mental health has recently been appreciated within proposed oral-brain axis. This study examined structure and composition salivary a large-scale population-based cohort individuals reporting symptoms (n = 306) compared to mentally healthy controls 164) using 16S rRNA sequencing. Mental were evaluated validated questionnaires included depression, anxiety, posttraumatic stress disorder (PTSD), with accompanying periodontal outcomes. Participants also...
Chronic systemic inflammation has been implicated in trauma exposure, independent of a psychiatric diagnosis, and posttraumatic stress disorder (PTSD) its highly comorbid conditions, such as metabolic syndrome (MetS). The present study used network analysis to examine the interacting associations between pro-inflammatory cytokines, (PTS) symptoms symptom clusters, individual components MetS, cohort 312 participants (n = 139 PTSD cases, n 173 trauma-exposed controls). Pro-inflammatory...
The Y-Specific Simple Sequence Length Polymorphism (SSLP) of the locus DYS19 was investigated in two Slovakian samples--Bratislava and Medzev--and German samples--Bremen Hannover. allele frequencies show a significant difference between samples.