A5101802995- Endometrial and Cervical Cancer Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Uterine Myomas and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Endometriosis Research and Treatment
- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- MRI in cancer diagnosis
- Cancer, Stress, Anesthesia, and Immune Response
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
- Lipoproteins and Cardiovascular Health
- Hedgehog Signaling Pathway Studies
- Advanced biosensing and bioanalysis techniques
- Peroxisome Proliferator-Activated Receptors
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Infection Control and Ventilation
- Medical Imaging Techniques and Applications
- Respiratory viral infections research
- Nasolacrimal Duct Obstruction Treatments
University of Miami
2021-2024
Sylvester Comprehensive Cancer Center
2024
Emory University
2022-2024
McGill University Health Centre
2020-2023
University of Washington
2023
Brigham and Women's Hospital
2023
University of Wisconsin Health
2023
Kura Oncology (United States)
2021
Stanford University
2020
University of California, Berkeley
2019
Purpose To determine the increase in clinically significant cancer detection prostate with increasing number of core samples obtained by using cognitive MRI-targeted transrectal US biopsy. Materials and Methods This retrospective cross-sectional study included 330 consecutive patients (mean age, 64.3 years; range, 42–84 years) who underwent multiparametric MRI from March 2012 to July 2017 had an index lesion that subsequently biopsy at least five (which were sequentially labeled) per lesion....
Abstract Recently we demonstrated that incorporating p ‐fluorophenylalanine (pFF) into phosphotriesterase dramatically improved folding, thereby leading to enhanced stability and function at elevated temperatures. To further improve the of fluorinated enzyme, Rosetta was used identify multiple potential stabilizing mutations. One such variant, pFF‐F104A, exhibited activity temperature maintained over many days in solution room temperature.
Abstract While it is known that cancer cell interactions with vascular endothelial cells (ECs) drive metastatic extravasation from blood vessels into secondary tumor sites, the mechanisms of action are still poorly understood. Here, we tested hypothesis neuraminidase‐induced degradation EC surface glycocalyx (GCX), particularly sialic acid (SA) residue components GCX, will substantially increase attachment to ECs. To our knowledge, study first isolate role GCX SA residues in endothelium,...
There is a paucity of research devoted to understanding the communication restrictions encountered by facial paralysis patients. We aim explore relationship between patient-reported in communicative participation and objective severity using validated scales movement.We performed pilot retrospective study consecutive series adult patients with diagnosis unilateral paralysis. In addition baseline demographics, subjects were evaluated Communicative Item Participation Bank Short Form (CPIB),...
We generated a novel human apolipoprotein E (apoE)-mimetic peptide, designated EpK. EpK contains an N-terminal cysteine residue, low-density lipoprotein receptor-binding fragment, 6 × lysine linker and lipid-binding fragment. The recombinant peptide was expressed in Escherichia coli, purified with chitin bead column followed by Heparin Sepharose CL-6B to yield pure peptide. displayed high solubility aqueous solution at neutral pH adopted low content of α-helical structure which significantly...
The Ovarian-Adnexal Reporting and Data System (O-RADS) MRI risk stratification system provides a standardized lexicon evidence-based score for evaluation of adnexal lesions. goals the are to improve report quality communication between radiologists clinicians, reduce variability in reporting language, optimize management O-RADS is based on presence or absence specific imaging features, including lipid content, enhancing solid tissue, number loculi, fluid type. probability malignancy ranges...
Abstract Deep learning (DL) has been proposed to automate image segmentation and provide accuracy, consistency, efficiency. Accurate of lipomatous tumors (LTs) is critical for correct tumor radiomics analysis localization. The major challenge this task data heterogeneity, including morphological characteristics multicenter scanning protocols. To mitigate the issue, we aimed develop a DL-based Super Learner (SL) ensemble framework with different correction normalization methods....
Abstract Adenoid cystic carcinoma (ACC) is a rare and lethal malignancy that originates in secretory glands of the head neck. A prominent molecular feature ACC overexpression proto-oncogene MYB. has poor long-term survival due to its high propensity for recurrence protracted metastasis. Currently, clinical technologies lack efficiency distinguish patient prognosis prior redevelopment. We hypothesize metastatic can be detected by monitoring tumor-specific MYB expression patients’ blood....
Abstract High-grade gliomas are the most common type of malignant intracranial tumor with dismal five-year prognostic outcomes despite developments in chemoradiotherapy and surgical intervention. Distinct oncogenes associated tumorigenesis progression have been identified, providing targets for potential therapeutic interventions modeling efforts. In this study, we evaluated efficacy vectors targeting EGFR PTEN, individually combination to produce high-grade brain gliomas. Four groups rats...
Adenoid cystic carcinoma (ACC) is a rare and lethal malignancy that originates in secretory glands of the head neck. A prominent molecular feature ACC overexpression proto-oncogene MYB. has poor long-term survival due to its high propensity for recurrence protracted metastasis. Currently, clinical technologies lack efficiency distinguish patient prognosis prior redevelopment. We hypothesize metastatic can be detected by monitoring tumor-specific MYB expression patients' blood. developed...