A5068685657- Coronary Interventions and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Digestive system and related health
- Neuroscience of respiration and sleep
- Cardiac Arrhythmias and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Coronary Artery Anomalies
- Erythrocyte Function and Pathophysiology
- Vascular Procedures and Complications
- Advanced X-ray and CT Imaging
- Adenosine and Purinergic Signaling
- Venous Thromboembolism Diagnosis and Management
- Microscopic Colitis
- Health, Environment, Cognitive Aging
- Nitric Oxide and Endothelin Effects
- Case Reports on Hematomas
- Cardiac pacing and defibrillation studies
- Computational Drug Discovery Methods
- Intracranial Aneurysms: Treatment and Complications
- Clinical practice guidelines implementation
- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
Karolinska University Hospital
2011-2024
Karolinska Institutet
2011-2024
Ollscoil na Gaillimhe – University of Galway
2021
Royal Brompton Hospital
2021
VA Palo Alto Health Care System
2021
Stanford University
2021
Svenska Örtmedicinska Institute
2011
Humboldt-Universität zu Berlin
2003
Charité - Universitätsmedizin Berlin
2003
Medizinische Hochschule Hannover
2003
The independent clinical correlates and prognostic impact of QRS prolongation in heart failure (HF) with reduced preserved ejection fraction (EF) are poorly understood. rationale for cardiac resynchronization therapy (CRT) EF is unknown. aim was to determine the prevalence of, with, HF EF.We studied 25,171 patients (age 74.6 ± 12.0 years, 39.9% women) Swedish Heart Failure Registry. We assessed width 40 other clinically relevant variables. Correlates were multivariable logistic regression,...
Abstract Background Cholinesterase inhibitors (ChEIs) are the first-line symptomatic pharmacologic treatment for patients with mild-to-moderate Alzheimer's disease (AD). Although target organ this group of drugs is brain, inhibition enzyme may affect cardiac function through vagotonic and anti-inflammatory effects. Objective To assess impact ChEIs on outcomes in AD who have experienced myocardial infarction (MI) prior to diagnosis. Methods Patients had MI before they were diagnosed or mixed...
Microemboli observed during coronary angiography can cause silent ischemic cerebral lesions. The aim of this study was to investigate if the number particulate microemboli is influenced by access site used.Fifty-one patients with stable angina pectoris referred for were randomized right radial or femoral arterial access. passing middle arteries continuously registered transcranial Doppler.The median (minimum-maximum range) numbers emboli significantly higher 10 (1-120) than 6 (1-19) More...
The aim of this study was to evaluate the implementation a novel extra corporeal cardiopulmonary (ECPR) program in greater Stockholm area with focus on feasibility, safety aspects and clinical outcomes. Prospective observational ECPR including patients OHCA from January 2020 December 2022, fulfilling criteria: age 18–65 years, initial shockable rhythm or pulseless electrical activity, witnessed arrest, bystander resuscitation refractory arrest after three cycles advance cardiac life support....
Lactose intolerance with adult-onset is due to the inadequate enzymatic activity of lactasephlorizin hydrolase (LPH). It frequently seen in patients Crohn disease, but mechanism remains be elucidated. Two DNA genotypes, C/C(-13910) and G/G(-22018), located upstream from LCT locus, gene encoding for LPH, were recently identified as representing genetic markers lactose intolerance. We utilized these two genotypes study their role inflammatory bowel disease.We investigated prevalence variants...
Background and Aims: To evaluate genotyping for two DNA variants (c.1993+327C>T c.1438+117G>A), recently found to be associated with adult-type hypolactasia, in the diagnosis of lactose intolerance. Methods: In total, 166 consecutive patients gastrointestinal symptoms mimicking hypolactasia admitted clinic between March 2002 December were included. Genotyping c.1438+117G>A) standard H2 breath test was performed. Results: Among 116 positive test, c.1993+327C variantwas detectablein...
Red blood cells (RBCs) are suggested to play a role in cardiovascular regulation by exporting nitric oxide (NO) bioactivity and ATP under hypoxia. It remains unknown whether such beneficial effects of RBCs protective patients with acute myocardial infarction. We investigated from ST-elevation infarction (STEMI) protect against ischemia-reperfusion injury effect involves NO purinergic signaling the RBCs. STEMI undergoing primary coronary intervention healthy controls were administered...
Red blood cells from patients with STEMI and systemic inflammation induce endothelial dysfunction ex vivo. The RBC-induced is mediated through increased arginase 1 a shift in the redox balance toward oxidative stress. Inhibition of or free radicals attenuates impairment function. study suggests that red deserve attention as key player STEMI.
Background: In patients with chronic coronary syndrome undergoing percutaneous intervention, the optimal timing of P2Y12 inhibitors’ administration is uncertain. We compared pretreatment versus treatment in catheterization laboratory (In-Cathlab) a real-world population. Methods: Swedish Coronary Angiography and Angioplasty Registry, all angiography ad hoc between 2006 2017 were identified. Pretreatment was defined as inhibitor before angiography, outside laboratory. Outcomes net adverse...
Abstract Background During the last decades, there have been substantial improvements in treatment techniques for percutaneous coronary intervention (PCI). Yet, in-stent restenosis (ISR) continues to pose significant challenges as they account 10% of all PCI cases and are associated with worse outcome compared de-novo lesions. When assessing ISR PCI, balloon angioplasty drug-coated balloons (DCB) is frequently used. Purpose Despite frequent use DCB, a lack long-term data ensuring safety DCB...
Abstract Background Red blood cells (RBC) are suggested to act as important mediators in the regulation of cardiovascular function by exporting nitric oxide (NO) bioactivity and ATP under hypoxic/ischemic conditions. In addition, RBCs known protect from ischemia-reperfusion injury via export NO experimental settings. However, it remains unknown if such beneficial effects protective patients with acute myocardial infarction. Purpose To investigate whether ST-elevation infarction (STEMI)...
Congenitally corrected transposition of the great arteries (ccTGA) is a rare congenital heart anomaly with atrioventricular and ventriculoarterial discordance that often associated other cardiac coronary artery anomalies. Here, we report case patient ccTGA non-ST elevation myocardial infarction (NSTEMI) challenging anatomy was treated stress-perfusion magnetic resonance imaging (spCMR) guided percutaneous intervention (PCI).A 46-year-old male smoker ccTGA, dyslipidaemia, diabetes Type 2...