A5092415740- Congenital gastrointestinal and neural anomalies
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Receptor Mechanisms and Signaling
- Regulation of Appetite and Obesity
- Gut microbiota and health
- Biochemical Analysis and Sensing Techniques
Monash University
2024
The enteric nervous system (ENS) consists of an extensive network neurons and glial cells embedded within the wall gastrointestinal (GI) tract. Alterations in neuronal distribution function are strongly associated with GI dysfunction. Current methods for assessing suffer from undersampling, partly due to challenges imaging analyzing large tissue areas, operator bias manual analysis. We present Gut Analysis Toolbox (GAT), image analysis tool designed characterization their neurochemical...
Abstract The enteric nervous system (ENS) plays an important role in coordinating gut function. ENS consists of extensive network neurons and glial cells within the wall gastrointestinal tract. Alterations neuronal distribution, function, type are strongly associated with neuropathies (GI) dysfunction can serve as biomarkers for disease. However, current methods assessing counts distribution suffer from undersampling. This is partly due to challenges imaging analyzing large tissue areas,...
Summary All cells face the challenge of integrating multiple extracellular signals to produce relevant physiological responses. Different combinations G protein-coupled receptors, when co-expressed, can lead distinct cellular outputs, yet molecular basis for this co-operativity is controversial. One such interaction reversal, from inhibition excitation, at dopamine D2 receptor in ghrelin receptor’s presence, defecation control. Here we demonstrate that reversal activity, excitatory, occurs...