A5100758804- Pain Management and Opioid Use
- Anesthesia and Pain Management
- Climate Change and Health Impacts
- Inflammatory Bowel Disease
- Connective tissue disorders research
- Metabolism and Genetic Disorders
- Epigenetics and DNA Methylation
- Urban and spatial planning
- vaccines and immunoinformatics approaches
- Head and Neck Cancer Studies
- Nausea and vomiting management
- Medical Imaging and Pathology Studies
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Brain Metastases and Treatment
- Gene expression and cancer classification
- Colorectal Cancer Surgical Treatments
- Microscopic Colitis
- Antibiotic Resistance in Bacteria
- Lung Cancer Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Emergency and Acute Care Studies
- Trauma and Emergency Care Studies
- Monoclonal and Polyclonal Antibodies Research
- Pelvic floor disorders treatments
Weatherford College
2023-2024
Korea University
2023
Korea Advanced Institute of Science and Technology
2016-2023
Samsung (South Korea)
2020-2022
Sungkyunkwan University
2020-2022
Abstract Non-self epitopes, whether originated from foreign substances or somatic mutations, trigger immune responses when presented by major histocompatibility complex (MHC) molecules and recognized T cells. Identification of immunogenically active neoepitopes has significant implications in cancer virus medicine. However, current methods are mostly limited to predicting physical binding mutant peptides MHCs. We previously developed a deep-learning based model, DeepNeo, identify immunogenic...
CpG islands (CGIs) are interspersed DNA sequences that have unusually high ratios and GC contents. CGIs typically located in the promoter of protein-coding genes. They normally lack methylation but become hypermethylated induce repression associated genes cancer. However, biological functions non-promoter (orphan CGIs) largely remain unclear. Here, we identify orphan do not map to any or non-coding transcripts possess chromatin transcriptional marks reflect enhancer activity (termed eCGIs)....
Intravenous patient-controlled analgesia (IV PCA; IVA) is the most widely used method for postoperative pain management. An appropriate IVA regimen required, depending on expected intensity of after surgery. This study that a decrease in second prescription rate elective cesarean section (CS) would help establish an initial IVA. We retrospectively reviewed records 632 patients who were prescribed CS. classified into phase 1 (basal 15.00 mcg/hours, bolus dose mcg, total volume 100 mL) and 2...
Major progress in disease genetics has been made through genome-wide association studies (GWASs). One of the key tasks for post-GWAS analyses is to identify causal noncoding variants with regulatory function. Here, on basis >2000 functional features, we developed a convolutional neural network framework combinatorial, nonlinear modeling complex patterns shared by risk scattered among multiple associated loci. When applied major psychiatric disorders and autoimmune diseases, immune...
The aim of this study was to evaluate the impact coronavirus disease 2019 (COVID-19) on treatment outcomes in critically ill patients with carbapenem-resistant Acinetobacter baumannii (CRAB) bloodstream infection (BSI). This single-centre, retrospective cohort conducted a 1,048-bed university-affiliated tertiary hospital Republic Korea from January 2021 March 2022. participants included consecutive hospitalised adult (aged ≥18 years) intensive care unit CRAB monomicrobial BSI. During period,...
Administering opioids via intravenous patient-controlled analgesia is a prevalent approach for managing postoperative pain. Nevertheless, due to concerns about opioid-related side effects and the potential opioid tolerance, there growing emphasis on adopting opioid-sparing techniques pain management. We aimed investigate effect of adding basal rate infusion in fentanyl-based IVA following cesarean section (CS).
Objective Brain metastasis (BM) was a common complication of patient with non-small cell lung cancer (NSCLC) and associated poor prognosis. The study to evaluate the effect cerebral infarction (CI) which originated from emboli on risk BM in NSCLC for preventive therapy strategy. Methods Three hundred seven patients newly diagnosed our institute July 2013 2018 were retrospectively analyzed. diagnostic criteria CI refereed Updated Criteria Population-Based Stroke Transient Ischemic Attack...
Joubert syndrome and mitochondrial disease are rare congenital diseases in which a wide range of symptoms affects multiple organs. Patients with these present characteristic related to the musculoskeletal, respiratory, neurological systems, make it difficult for anesthesiologists manage patient's airway choose appropriate anesthetic drugs. A 13-year-old male patient underwent elective surgery insert continuous ambulatory peritoneal dialysis catheter. Anesthesia was induced maintained...
Background: There are insufficient studies on clinical and environmental factors that affect the use of emergency medical services (EMS) in pediatric patients. Objectives: We sought to identify characteristics patients transported department (ED) by EMS meteorological affecting EMS. Methods: reviewed records younger than 19 years who visited ED from January 2005 December 2019. Results: The rate was higher among older [adjusted odds ratio (aOR): 1.12; 95% confidence interval (CI): 1.11 -...