A5015761151- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Caveolin-1 and cellular processes
- Inflammatory Biomarkers in Disease Prognosis
- Brain Metastases and Treatment
- Cancer, Hypoxia, and Metabolism
- HER2/EGFR in Cancer Research
- Cutaneous lymphoproliferative disorders research
- Neuroendocrine Tumor Research Advances
- Head and Neck Cancer Studies
- Frailty in Older Adults
- Nutrition and Health in Aging
- RNA Research and Splicing
- Esophageal Cancer Research and Treatment
- Proteoglycans and glycosaminoglycans research
Catholic University of Korea
2015-2024
Uijeongbu St. Mary's Hospital
2014-2023
Cheongju St. Mary's Hospital
2013
St. Vincent's Hospital
2009-2012
The microRNA‐200 (miR‐200) family plays a major role in specifying epithelial phenotype by preventing expression of the transcription repressors ZEB1 and ZEB2, which are well‐known regulators epithelial‐to‐mesenchymal transition (EMT) tumors including oral squamous cell carcinoma (OSCC). Here, we elucidated whether miR‐200 members control RNA‐binding protein quaking (QKI), newly identified tumor suppressor that is regulated during EMT. We predicted miR‐200a miR‐200b could recognize QKI...
The purpose of the study is to investigate associations between sarcopenia and health-related quality life in elderly men women Korea.In a cross-sectional using data from 2008 2011 Korean National Health Nutrition Examination Survey, 4,937 adults aged 60 years older who underwent dual-energy X-ray absorptiometry scan were included study. Sarcopenia defined as an appendicular skeletal muscle index two standard deviations or more below mean for young, healthy reference populations. was...
Dickkopf-1 (DKK1) is a Wnt/ß-catenin pathway antagonist related to gastric cancer (GC) carcinogenesis. However, the prognostic role of combined DKK1 and ß-catenin expression in advanced GC (AGC) not clear.In total, 158 patients with AGC who underwent resection were enrolled this study. was evaluated whole tumor sections by immunohistochemistry.DKK1 high 73 (46.2%) patients, while positive 51 (32.3%) patients. The positively correlated that (P < 0.001). significantly associated N stage (N2...
CD8+ tumor-infiltrating lymphocytes (TILs) play a major role in antitumor immunity. High endothelial venules (HEVs) are related to diverse immune cells solid tumors. We analyzed and Foxp3+ TILs combination with HEVs determine their prognostic advanced gastric cancer (AGC). enrolled 157 patients AGC this study. The densities of were calculated using immunohistochemical staining. evaluated by MECA-79 expression. identified 60 (38.2%) cases was significantly associated an increased number (p =...
Considering the protumorigenic roles of interleukin-6 (IL-6) transsignaling, we assessed serum levels IL-6, soluble receptor (sIL-6R), and glycoprotein 130 (sgp130) in 143 patients with breast cancer. Serum IL-6 were elevated advanced T N stage. sIL-6R lower estrogen receptor-positive The median values sgp130 did not differ between recurrence those without recurrence. However, higher at diagnosis associated significantly shorter relapse-free survival
Abstract To compare the incidence of brain metastases advanced non-small cell lung cancer (NSCLC) treated with systemic cytotoxic chemotherapy (CC) and targeted therapy (TT), we performed a large-scale, retrospective, nationwide, cohort study. The population data were extracted from Health Insurance Review Assessment Service Korea database January 1, 2011, to November 30, 2016. Of 29,174 patients newly diagnosed stage IIIB or IV NSCLC who received treatment, investigated initial subsequent...
Human papillomavirus ( HPV ) infection plays a significant role in the development and progression of head neck squamous cell carcinoma HNSCC ). Expression mi R ‐21 has prognostic wide variety cancers. The upregulation suppresses number target genes, including phosphatase tensin homologue PTEN programmed death 4 PDCD4 We investigated association between expression clinical features using stratified analysis based on status. status tissues from 167 patients were evaluated situ hybridization....
Background We aimed to evaluate the expression of APOBEC3A (A3A), 3B (A3B) mRNA, and germline APOBEC3A/B deletion polymorphism in patients with breast cancers investigate correlation between their expressions clinicopathological characteristics. Methods RNA DNA samples were extracted from 138 cancer tissues adjacent normal tissues. The levels A3A A3B mRNA transcripts determined using quantitative real-time polymerase chain reaction. Insertion PCR assays performed detect allele. serum...
Der Sheng Sun, M.D., Yeon Joo Chun, Jeong Hwa Lee, Sang Hyun Gil, Byoung Yong Shim, Ok Kyung R.N.*, In Soon Jung, M.S.W.† and Hoon Kyo Kim, M.D.. J Hosp Palliat Care 2009;12:20-6. https://doi.org/10.14475/kjhpc.2009.12.1.20
Autophagy, a cellular degradation process, has complex roles in tumourigenesis and resistance to cancer treatment humans. The aim of this study was explore the expression levels autophagy-related proteins patients with rectal evaluate their clinical role neoadjuvant chemoradiotherapy setting. All specimens evaluated were obtained from 101 colorectal who had undergone curative surgery. primary outcomes measured two (microtubule-associated protein 1 light chain 3 beta (LC3β) beclin-1) by...
Background/Aims This study was conducted to identify risk factors that predict vulnerability cancer therapy on the basis of clinical, geriatric, and quality life assessment before starting treatment in elderly patients. Methods Seventy-five patients aged 65 years over with newly diagnosed stage IV solid receiving chemotherapy were analyzed. Clinical laboratory data collected. The geriatric performed using Korean versions Modified Barthel Index, Instrumental Activities Daily Living,...
Background/Aim. Bax-interacting factor-1 (Bif-1) plays a crucial role in apoptosis and autophagy. The aim of this study was to evaluate Bif-1 protein expression its prognostic significance colorectal cancer (CRC). Methods. We analyzed 251 resected specimens from patients with CRC by immunohistochemistry using tissue microarray. Results. Low observed 131 (52.2%) high 120 (47.8%). No significant differences were clinicopathological parameters between low expression. Kaplan-Meier survival...
Background and Objectives: The prediction of the prognosis effect neoadjuvant therapy is vital for patients with advanced or unresectable colorectal carcinoma (CRC). Materials Methods: We investigated several tumor microenvironment factors, such as intratumoral budding (ITB), desmoplastic reaction (DR), Klintrup-Mäkinen (KM) inflammation grade, tumor-stroma ratio (TSR) in pretreatment biopsy samples (PBSs) collected from CRC. A total 85 74 rectal carcinomas 11 colon cancers treated at our...
Abstract Chemotherapy‐induced nausea and vomiting (CINV) is an unbearable side effect. Identifying high emetic risk patients providing more active antiemetics strategies are mandatory to improve the tolerability of chemotherapy. In this prospective cohort study, leptin, ghrelin, substance P were measured at baseline, day 3, 14 during first cycle Nausea each for 4 days Eighty‐two enrolled. Colorectal cancer (61%) gastric (35.4%) common types. All received moderate Forty‐five (54.9%) had...
Objective . Caveolin-1 (Cav-1), as the main component of caveolae, has complex roles in tumourigenesis human malignancies. We investigated Cav-1 primary and metastatic tumor cells gastric cancer (GC) its association with clinical outcomes. Methods. retrieved 145 cases GC who had undergone curative gastrectomy. The expression levels was evaluated by immunohistochemistry, clinicopathological parameters patient survival analyzed. Results. High protein stomach lymph node 12.4% (18/145) 16.5%...
e17062 Background: Clear cell ovarian cancer is rare, accounts for about 3-10% of epithelial carcinoma, and known to be associated with endometriosis. This tumor type has poor prognosis due inherent chemoresistance. We investigated clinical characteristics prognostic factors clear in South Korea. Methods: reviewed the medical records 308 patients histology who underwent debulking surgery from 21 institutions Korea between 1995 2015. Results: Mean age was 51 years (range, 25-81) 194 (63.7%)...
We compared the efficacy of granisetron transdermal system (GTS) with that ondansetron for controlling chemotherapy-induced nausea and vomiting (CINV) in patients treated highly emetogenic chemotherapy (HEC).We randomized a total 389 to groups by GTS before HEC. The primary endpoint was percentage achieving complete response (CR; no retching/vomiting/rescue medication) CINV from time initiation 24 hours after last administration (prespecified non-inferiority margin 15%). Quality life (QoL)...