A5012202111- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Urinary and Genital Oncology Studies
- Urologic and reproductive health conditions
- Neuroendocrine Tumor Research Advances
- Testicular diseases and treatments
- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Breast Cancer Treatment Studies
- Urological Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Breast Lesions and Carcinomas
- Colorectal and Anal Carcinomas
- Lymphatic Disorders and Treatments
- Tuberous Sclerosis Complex Research
- Reproductive tract infections research
- Tumors and Oncological Cases
- Peptidase Inhibition and Analysis
- Cancer and Skin Lesions
- Gestational Trophoblastic Disease Studies
- Caveolin-1 and cellular processes
- Wnt/β-catenin signaling in development and cancer
- Ear and Head Tumors
- Protein Tyrosine Phosphatases
National Police Hospital
2022-2024
Inje University Sanggye Paik Hospital
2021-2022
Catholic University of Korea
2017-2018
Uijeongbu St. Mary's Hospital
2017-2018
Ulsan College
2011-2017
Asan Medical Center
2012-2017
University of Ulsan
2011-2017
Seoul National University Hospital
2013
There are limited conventional chemotherapy options for biliary tract cancers (BTCs), a heterogenous group of lethal, rare malignancies. The receptor tyrosine kinase (RTK) is closely associated with the progression human malignancies through regulation cell cycle. Overexpression or amplification RTKs has been investigated as potential biomarker and therapeutic target in BTC; herein, we investigate value such interventions.
Dickkopf-1 (DKK1) is a Wnt/ß-catenin pathway antagonist related to gastric cancer (GC) carcinogenesis. However, the prognostic role of combined DKK1 and ß-catenin expression in advanced GC (AGC) not clear.In total, 158 patients with AGC who underwent resection were enrolled this study. was evaluated whole tumor sections by immunohistochemistry.DKK1 high 73 (46.2%) patients, while positive 51 (32.3%) patients. The positively correlated that (P < 0.001). significantly associated N stage (N2...
The non-receptor tyrosine phosphatase SHP2 has scaffolding functions in signal transduction cascades downstream of growth receptors. A recent study suggested that acts as a tumor suppressor during hepatocellular carcinoma (HCC) development. Herein we examined whether links the HBx-NF-κB pathway to EGFR signaling HCC overexpression HBx or NF-κB led increased expression via binding Shp2 promoter. EGF treatment induced ERK activation well rapid assembly SHP2, EGFR, and Gab1. Upon LPS...
Endoscopic resection is the first-line treatment for rectal neuroendocrine tumors (NETs) measuring <1 cm and those between 1 2 in size. However, conventional endoscopic cannot achieve complete all cases. We aimed to analyze clinical outcomes of precut mucosal (EMR-P) used management NET.EMR-P was treat NET 72 patients at a single tertiary center 2011 2015. Both, circumferential precutting EMR were performed with same snare device patients. Demographics, procedural details, histopathological...
Orbital solitary fibrous tumor (SFT) has recently been proposed as the encompassing terminology for hemangiopericytoma, giant cell angiofibroma (GCAF), and histiocytoma of orbit. The lacrimal gland is a very rare location both SFT GCAF. A 39-year-old man presented with painless left upper eyelid mass. An orbital computed tomography scan identified 1.1 cm-sized well-defined nodule located in gland. He underwent mass excision. Histopathologic examination showed proliferation relatively uniform...
Objective . Caveolin-1 (Cav-1), as the main component of caveolae, has complex roles in tumourigenesis human malignancies. We investigated Cav-1 primary and metastatic tumor cells gastric cancer (GC) its association with clinical outcomes. Methods. retrieved 145 cases GC who had undergone curative gastrectomy. The expression levels was evaluated by immunohistochemistry, clinicopathological parameters patient survival analyzed. Results. High protein stomach lymph node 12.4% (18/145) 16.5%...
Background: Primary squamous cell carcinoma (SCC) of the upper genital tract, including endometrium, fallopian tubes, and ovaries, is extremely rare.It must be distinguished from mucosal extension primary cervical SCC because determination tumor site important for staging.However, patients with tubes or ovarian surface have often undergone prior hysterectomy inadequate examination cervix, making it difficult to determine site.Methods: We compared histologic findings, p16 INK4a expression,...
Teratoma: An Unusual Case ReportWe report an unusual case of 9.5-cm-sized embryonal rhabdomyosarcoma arose from a mediastinal mature teratoma in 46-yr-old man.A man presented with chest trauma as result accident at 10 September 2011.On X-ray, anterior mass was detected.To obtain further information, computed tomography (CT) contrast enhancement performed, revealing mass.Complete surgical excision performed and entire specimen evaluated.Pathologic diagnosis arising cystic teratoma.After...
ABSTRACT Diffuse pulmonary lymphangiomatosis (DPL) is a rare disorder involving the intrathoracic lymphatic system from mediastinum to pleura. Although DPL developmental abnormality and pathologically benign, it has various clinical presentations progressive course. We recently studied case of in 35‐year‐old man presenting with cough hemoptysis unilateral chylothorax. A chest computed tomography scan showed diffuse interstitial thickening along peribronchovascular bundles intralobular septae...
Transitional cell metaplasia (TCM) of the uterine cervix and vagina is typically seen in patients with adrenogenital syndrome high serum androgen levels those under treatment as well some peri/postmenopausal women. Considering that TCM occurs increased levels, a microenvironment altered sex hormones might be involved urothelial-like differentiation observed TCM. To investigate histogenetic role development, we compared distribution patterns intensity receptor (AR), estrogen (ER), GATA3 (a...
Abstract Background : Basaloid squamous cell carcinoma (BSCC) is a rare, aggressive variant of with high stage presentations and poor outcomes. It especially difficult to differentiate BSCC an adenoid cystic pattern from grade (ACC) using small biopsies. Case presentation: We describe different clinicopathological, immunohistochemical, ultrastructural findings (n=2) ACC (n=1) the uterine cervix. Despite similar histopathologic features, had significantly higher cellular atypism distinct...
Metaplastic carcinoma of the breast is a heterogeneous group neoplasms with mixed epithelial and mesenchymal differentiation. rare aggressive malignancy, high recurrence metastasis. chondroid differentiation an uncommon subtype that tends to have relatively good prognosis than other subtypes. We report imaging features three cases pathologically proven metaplastic as follows: high-density mass amorphous or coarse calcifications on mammography; microlobulated partially indistinct, complex...
Infection with high-risk (HR) Human Papillomavirus (HPV) is associated the development of precancerous lesions or invasive carcinoma uterine cervix. Thus, high viral load (VL) HR-HPV DNA currently serves as a representative quantitative marker for cervical cancer. However, clinical significance low HPV VL remains undetermined. This study aimed to evaluate association between and cytology/histologic diagnosis samples. We searched electronic medical databases resultant analyses genotyping...