A5063334180- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Metastasis and carcinoma case studies
- Renal cell carcinoma treatment
- Renal and related cancers
- HER2/EGFR in Cancer Research
- Lymphoma Diagnosis and Treatment
- Frailty in Older Adults
- Urinary and Genital Oncology Studies
- Multiple and Secondary Primary Cancers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- PI3K/AKT/mTOR signaling in cancer
- Monoclonal and Polyclonal Antibodies Research
- Gastrointestinal Tumor Research and Treatment
- Bladder and Urothelial Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Pancreatic and Hepatic Oncology Research
- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Economic and Financial Impacts of Cancer
- Urological Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Health Systems, Economic Evaluations, Quality of Life
- Endometrial and Cervical Cancer Treatments
Inje University Busan Paik Hospital
2014-2024
Inje University
2013-2022
Moffitt Cancer Center
2017-2019
Yonsei University
2010-2011
Inje University Seoul Paik Hospital
2005
<b><i>Background:</i></b> To investigate the role of phosphoinositide 3-kinase (PI3K) pathway activation in human epidermal growth factor receptor 2 (HER2)-targeted therapy. <b><i>Methods:</i></b> We evaluated predictive roles PI3K, catalytic alpha (PIK3CA), and phosphatase tensin homolog (PTEN) HER2-based therapy (either trastuzumab or lapatinib). PTEN expression <i>PIK3CA</i> mutation were analyzed using immunohistochemistry...
We performed this study to analyze the clinical features and prognosis of Korean patients with liposarcoma.Between October 1986 April 2013, 231 who were diagnosed liposarcoma by histologic examination enrolled in study.The distribution subtypes was well-differentiated (n = 97, 42%), myxoid 74, 32%), dedifferentiated 32, 13.9%), pleomorphic 15, 6.5%), round-cell 13, 5.6%). The majority liposarcomas located lower extremities (35.5%) retroperitoneum (34.2%). Prognosis worse for trunk group...
The purpose of this study was to evaluate clinical characteristics and treatment pattern ovarian clear cell carcinoma (OCCC) in Korea the role adjuvant chemotherapy early stage.Medical records 308 cases from 21 institutions were reviewed data including age, performance status, endometriosis, thromboembolism, stage, cancer antigen 125, treatment, recurrence, death collected.Regarding stage OCCC, it I 194 (63.6%), II 34 (11.1%), III 66 (21.6%), IV 11 (3.6%) patients. All patients underwent...
We investigated the clinicopathologic information of patients with gastric cancer multiple primary cancers (GC-MPC) three or more sites.Between 1995 and 2009, 105,908 were diagnosed malignancy at Severance Hospital, Yonsei University Health System. Of these, 113 (0.1%) MPC sites registered, 41 (36.3%) these GC-MPC. retrospectively reviewed clinical data overall survival using medical records GC-MPC patients. defined synchronous as those occurring within 6 months first cancer, while...
Purpose We conducted a randomized, multicenter, phase III trial to compare S-1 plus docetaxel (DS) with cisplatin (SP) as adjuvant chemotherapy for stage gastric cancer patients. Materials and Methods Stage patients who had received curative gastrectomy D2 lymphadenectomy were randomized into equal groups receive of eight cycles DS (S-1 70 mg/m2/day on days 1-14 35 mg/m2on 1 8) every 3 weeks or SP 60 day 1) weeks. The primary endpoint was 3-year disease-free survival (DFS) rate. Results...
<b><i>Background:</i></b> HER2 positivity is reported to be <20% in gastric cancer. Clinicopathological characteristics will helpful understand the biological features of HER2-positive <b><i>Methods:</i></b> A total 813 cancer patients who underwent testing between January 2005 and December 2010 were included this study. <b><i>Results:</i></b> Ninety-five (11.7%) had Elevated serum carcinoembryonic antigen (CEA)...
Abstract Background Immune checkpoint inhibitor (ICI) or irinotecan-based chemotherapy is frequently used after failure of second-line paclitaxel plus ramucirumab treatment for patients with locally advanced unresectable metastatic gastric cancer (AGC). This study aimed to compare the efficacy between ICI and as third-line in AGC. Methods We retrospectively reviewed AGC, whose started July 2019 June 2021 at 17 institutions Korea. The group included who received nivolumab pembrolizumab,...
Because of rarity, role chemotherapy bladder adenocarcinoma are still unidentified. Therefore, we performed a retrospective analysis the clinical features and outcomes adenocarcinoma.Eligible patients for this were initially diagnosed with presented clinically no other primary site origin. The collected data included age, gender, performance status, stage, hemoglobin, albumin, initial date diagnosis, treatment modality utilized, response to treatment, presence relapse, last status patient,...
A major goal of breast cancer research is to prevent the molecular events that lead tumour metastasis. It well-established both cytoplasmic and mitochondrial reactive oxygen species (ROS) play important roles in cell migration Accordingly, this study examined mechanisms anti-metastatic effects NecroX-5, a ROS scavenger. NecroX-5 inhibited lung metastasis by ameliorating mouse model. In human cells, inhibition type-dependent. We observed effect correlated with reduction ROS, but MitoQ did not...
A subphrenic mass was noted on a surveillance computed tomography (CT) scan of 65-year-old man who had achieved complete remission oropharyngeal cancer after concurrent chemoradiotherapy. The 3.2 cm in size and showed multilobular enhancing pattern along the peritoneal lining. patient negative for hepatitis B surface antigen anti-hepatitis C virus antibody. His carcinoembryonic level within normal range. Contrast-enhanced CT revealed no liver. He underwent surgery, pale yellowish soft tumor...
We investigated the epidemiologic characteristics and prognostic significance of PIK3CA mutations/amplifications in curative resected liposarcoma.A total 125 liposarcoma tissue samples were collected over a 12-year period. mutations gene copy number amplifications analyzed by pyrosequencing fluorescence situ hybridization (FISH).Nine 105 liposarcomas (8.6%) had activating mutation. more frequent myxoid/round cell pleomorphic tumors compared with well-differentiated/dedifferentiated (13.3%...
The proper dose and schedule of sunitinib have yet to be established for patients with metastatic renal cell carcinoma (RCC) on hemodialysis. We reviewed two RCC hemodialysis who had been treated in Yonsei Cancer Center, University College Medicine. Fifty milligrams was administered intermittently after each session (3 or 4 times a week). Overall responses were partial response both cases. Progression-free survivals 16 6 months, respectively, at the time reporting (April 2010). Both subjects...
e17062 Background: Clear cell ovarian cancer is rare, accounts for about 3-10% of epithelial carcinoma, and known to be associated with endometriosis. This tumor type has poor prognosis due inherent chemoresistance. We investigated clinical characteristics prognostic factors clear in South Korea. Methods: reviewed the medical records 308 patients histology who underwent debulking surgery from 21 institutions Korea between 1995 2015. Results: Mean age was 51 years (range, 25-81) 194 (63.7%)...
Combination therapies with phosphoinositide 3-kinase (PI3K) inhibitors and trastuzumab (anti-human epidermal growth factor receptor [HER]2/neu antibody) are effective against HER2+ breast cancer. Isoform-selective PI3K elicit anti-tumor immune responses that distinct from those induced by of class I isoforms (pan-PI3K inhibitors). The present study investigated the therapeutic effect potential for stimulating immunity combined therapy an anti-HER2/neu antibody pan-PI3K inhibitor (GDC-0941)...
Wernicke encephalopathy is a disease that constitutes medical emergency, but one can be reversed with thiamine repletion if it recognized early. Patients cancer have high risk of because malnutrition, the use chemotherapeutic agents, and progression. Korsakoff syndrome follow or accompany encephalopathy. Although patients recover from via rapid thiamine, few syndrome. Here, case 76-year-old female patient who had primary peritoneal developed Wernicke-Korsakoff as result prolonged nutritional...
Cardiac metastases of renal cell carcinomas are rare, and usually clinically silent. A case a 53-year-old man without significant medical history, who presented with ventricular tachycardia, which resulted in cardiac mass the right ventricle is reported. On chest X-ray, echocardiography, CT scanning, esophagogastroduodenoscopy MRI, multiple metastatic masses were observed both lungs, kidneys, adrenal, stomach ventricle. The kidney gastric polyp revealed on biopsy to be carcinoma mixed...
Primary peritoneal carcinoma (PPC) is a rare cancer arising from the extraovarian peritoneum and of müllerian origin. PPC epithelial ovarian share similar clinical, histopathological, immunohistochemical features. Clinical symptoms findings include abdominal distension ascites. We experienced 2 cases which initially presented with cervical lymphadenopathy. Here, we report review literature.
We evaluated the efficacy and toxicity of mammalian target rapamycin inhibitors in Korean patients with metastatic renal cell carcinoma (mRCC) chronic insufficiency not requiring dialysis. mRCC dialysis treated everolimus or temsirolimus between January 2008 December 2014 were included. Patient characteristics, clinical outcomes, toxicities evaluated. Overall survival (OS) progression-free (PFS) durations according to degree impairment. Eighteen considered eligible for study (median age, 59...
This study evaluated whether combination therapy is more effective than monotherapy in elderly patients with metastatic or recurrent gastric cancer (MRGC) as first-line chemotherapy.Elderly (≥ 70 years) chemo-naïve MRGC were allocated to receive either (group A: 5-fluorouracil [5-FU]/oxaliplatin, capecitabine/oxaliplatin, capecitabine/cisplatin, S-1/cisplatin) B: 5-FU, capecitabine, S-1). In group A, starting doses 80% of standard doses, and they could be escalated 100% at the discretion...
45% of colon cancer patients are elderly, yet they often deviated from standard management. The MOSAIC trial favored FOLFOX over FL with superior oncologic outcomes; however, which regimen is most beneficial in elderly population remains unclear. This study aimed to compare the efficacy oxaliplatin-added chemotherapy and capecitabine monotherapy high-risk stage II/stage III patients.Colon ≥70 years age who received adjuvant at Inje University Busan Paik Hospital between February 2009 April...
This study investigated the therapeutic effects of combined local irradiation and anti-HER2/neu antibody in a mixed tumor mouse model comprised nonmetastatic neu-positive metastatic neu-negative tumor. While alone could control primary dose-dependent manner, it did not improve survival. Combined treatment anti-neu tumor-bearing BALB/c mice significantly improved survival (P < 0.5), even though growth was similar to that irradiated-alone group. The reduced masses lung increased immune cell...