A5042632487- Prostate Cancer Treatment and Research
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Acute Myeloid Leukemia Research
- RNA Interference and Gene Delivery
- Genomic variations and chromosomal abnormalities
- Medicinal Plant Pharmacodynamics Research
- Tea Polyphenols and Effects
- Prostate Cancer Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- CAR-T cell therapy research
- PI3K/AKT/mTOR signaling in cancer
- DNA Repair Mechanisms
- Immunotherapy and Immune Responses
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- BRCA gene mutations in cancer
- Acute Lymphoblastic Leukemia research
- Cancer-related gene regulation
- HER2/EGFR in Cancer Research
- Bone health and treatments
- Urinary Bladder and Prostate Research
- Xenotransplantation and immune response
Stanford Health Care
2024
Louisiana State University Health Sciences Center Shreveport
2003-2023
University of the Incarnate Word
2022
University of Colorado Anschutz Medical Campus
2021
University of Montana
2021
Denver Health Medical Center
2019
University of Colorado Denver
2019
Louisiana State University in Shreveport
1998-2011
University Medical Center
1999-2005
University Hospital and Clinics
1999-2005
Overlapping cloned cDNAs representing the entire sequence of rat fatty acid synthase mRNA have been isolated from a cDNA library and sequenced. Authenticity clones was supported by hybridization to amino-terminal sequencing 39 CNBr fragments. The full-length is 9156 nucleotides long includes an 84-nucleotide 5' noncoding region, 7515-nucleotide coding sequence, 1537-nucleotide 3' region; second species containing shortened also transcribed in rat. encoded subunit contains 2505 amino acids...
Fluorescence in situ hybridization using two or three probes was utilized to estimate the incidence of diploidy, disomy for sex chromosomes and 16 18, proportion Y- X-chromosome bearing sperm, a series normal males. Our results demonstrate importance an approach capable distinguishing from as most donors had levels diploidy higher than individual chromosomes. analyses suggest existence chromosome-specific mechanisms paternal non-disjunction, chromosome approximately 1.5 times common 16, over...
Activation of the c-Met and epidermal growth factor receptors (EGFR) promotes survival non-small cell lung cancer (NSCLC). Specific receptor antagonists have shown efficacy in clinic, but tumors often become resistant to these therapies. We investigated ability (-)-epigallocatechin-3-gallate (EGCG) inhibit proliferation, EGFR kinase activation several NSCLC lines.NSCLC lines with variable sensitivity antagonist erlotinib were studied. Cell was evaluated using proliferation colony formation...
We have examined the potential of a novel cytokine, interleukin-27 (IL-27), for gene therapy prostate cancer. IL-27 is most recently characterized member family heterodimeric IL-12-related cytokines and has shown promise in halting tumor growth mediating regression several cancer models. In present study, we efficacy new mode delivery to tumors: low-frequency ultrasound irradiation or "sonoporation." also by sonoporation treat reduce vivo. used three models immune-competent adenocarcinoma...
Invasion and subsequent metastasis is the major cause of death from most cancers including prostate cancer. Herein we report on potential tumor suppressive properties Rab7, a GTPase that regulates trafficking lysosomes. The movement lysosomes to cell surface in response environmental cues increases secretion proteinases invasion. We determined Troglitazone other members Thiazolidinedione family inhibit cell-surface directed lysosome cathepsin B through Rab7-dependent mechanism. Moreover,...
We evaluated the prevalence and relationship of serum prostate specific antigen (PSA) levels in a screening population men diagnosed with National Institutes Health (NIH) category IV prostatitis.In September 2001, 300 were randomly selected from our cancer awareness program to be for NIH prostatitis. After informed consent was obtained all patients completed survey had sample PSA before examination. Expressed prostatic secretions 227 participants. Patients classified according findings on...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Feb 2003The Prevalence Men With National Institutes Health Category IV Prostatitis and Association Serum Prostate Specific Antigen BRETT S. CARVER, CALEB B. BOZEMAN, B.J. WILLIAMS, DENNIS D. VENABLE CARVERBRETT CARVER , BOZEMANCALEB BOZEMAN WILLIAMSB.J. WILLIAMS VENABLEDENNIS View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)63959-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack...
No AccessJournal of UrologyInvestigative Urology1 Feb 1996Evidence for a Tumor Suppressor Gene Distal to BRCA1 in Prostate Cancer Briana J. Williams, Emma Jones, Xiao Lin Zhu, Michael R. Steele, Robert A. Stephenson, L. Ralph Rohr, and Arthur Brothman WilliamsBriana Williams More articles by this author , JonesEmma Jones ZhuXiao Zhu SteeleMichael Steele StephensonRobert Stephenson RohrL. Rohr BrothmanArthur View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66509-1AboutFull...
We have shown previously that, in astrocytoma cells, synemin is present at the leading edge, an unusual localization for intermediate filament (IF) protein. Here, we report that down-regulation with specific small hairpin RNAs (shRNAs) sharply decreased migration of cells. The presence edge also correlated a high migratory potential, as by comparing cells to carcinoma without edge. Synemin-silenced were smaller and spread more slowly than controls. In addition, silencing reduced...
The aim of this project was to demonstrate that an oncolytic herpes simplex virus type 1 (HSV-1) can replicate in a tissue- and tumor-specific fashion through both transcriptional (prostate-specific promoter, ARR2PB) translational (5′-untranslated regions (5′UTRs) rFGF-2) regulation essential viral gene, ICP27. We generated two recombinant viruses, ARR2PB-ICP27 (A27) ARR2PB-5′UTR-ICP27 (AU27) tested their efficacy toxicity vitro vivo. ARR2PB promoter caused overexpression ICP27 gene the...
No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Sep 2000SUPPRESSION OF PRIMARY TUMOR GROWTH AND THE PROGRESSION TO METASTASIS WITH p53 ADENOVIRUS IN HUMAN PROSTATE CANCER JAMES A. EASTHAM, WARREN GRAFTON, CINDY M. MARTIN, and B. JILL WILLIAMS EASTHAMJAMES EASTHAM More articles by this author , GRAFTONWARREN GRAFTON MARTINCINDY MARTIN WILLIAMSB. View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)67320-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack...
In Arabidopsis thaliana, the gene Tousled encodes a protein kinase of unknown function, but mutations in lead to flowering and leaf morphology defects. We have recently cloned mammalian Tousled-L ike K inase (TLK1B) found that it phosphorylates specifically histone H3, vitro vivo. now report effects overexpression kinase-dead mutant TLK1B mediates normal diploid cell line. Expression resulted reduction phosphorylated which could consequences mitotic segregation chromosomes. When analyzed by...
The RUNX transcription factors (RUNX1, RUNX2, and RUNX3) play essential roles in hematopoiesis skeletal development. Consistent with these differentiation cell cycle, the activity of both RUNX1 RUNX3 is perturbed cancer. To determine a role for prostate biology, we investigated expression epithelial lines normal tissue. RUNX1, were expressed tissue an immortalized, non-transformed line. We found that cancer-derived but not RUNX3. Next, sought to identify prostate-specific genes whose could...
Abstract Peptide growth factors have been proposed as mediators of smooth muscle-epithelial cell interactions in the human prostate; however, identity these molecules has not established. In this study, we compared expression levels messenger RNAs (mRNAs) encoding epidermal factor (EGF) receptor-related receptor tyrosine kinases (ErbB1 through 4), six EGF ligands, EGF, transforming (TGF)-α, amphiregulin (ARG), HB-EGF, betacellulin, and epiregulin, related molecule heregulin-α, a series 10...