A5054666066- Antifungal resistance and susceptibility
- COVID-19 Clinical Research Studies
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Fibroblast Growth Factor Research
- Thermal Regulation in Medicine
- Proteoglycans and glycosaminoglycans research
- Sepsis Diagnosis and Treatment
- Acute Myocardial Infarction Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Facial Rejuvenation and Surgery Techniques
- Hospital Admissions and Outcomes
- SARS-CoV-2 detection and testing
- Atrial Fibrillation Management and Outcomes
- Biosensors and Analytical Detection
- Pharmaceutical Practices and Patient Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Bacterial Infections and Vaccines
- Neutropenia and Cancer Infections
- Prostate Cancer Treatment and Research
- Respiratory viral infections research
- Reconstructive Facial Surgery Techniques
- Immune Response and Inflammation
- S100 Proteins and Annexins
- Surgical Sutures and Adhesives
Harvard University
2022-2024
American University of Beirut
2020-2023
Massachusetts General Hospital
2022-2023
Hartford Financial Services (United States)
2023
University of Birmingham
2023
Leeds Trinity University
2022
Neutrophils are a vital component of the innate immune system and play an essential function in recognition clearance bacterial fungal pathogens. There is great interest understanding mechanisms neutrophil dysfunction setting disease deciphering potential side effects immunomodulatory drugs on function. We developed high throughput flow cytometry-based assay for detecting changes to four canonical functions following biological or chemical triggers. Our detects phagocytosis, reactive oxygen...
The use of mature neutrophil (granulocyte) transfusions for the treatment neutropenic patients with invasive fungal infections (IFIs) has been focus multiple clinical trials. Despite these efforts, transfusion neutrophils resulted in limited benefit, likely owing to problems insufficient numbers and very short lifespan donor cells. In this report, we employed a system conditionally immortalized murine progenitors that are capable continuous expansion, allowing generation unlimited homogenous...
Antimicrobial resistance is a global public health issue, exacerbated by dispensing and purchasing antibiotics without prescription, common in low- middle-income countries, such as Lebanon. This study aimed to (1) describe behavioral patterns underpinning prescription among pharmacists patients, (2) reasons for, (3) attitudes toward these behaviors. A cross-sectional targeted respectively, identified through stratified random sampling convenience from all 12 Beirut quarters. Questionnaires...
Interleukin-6 (IL-6) has been linked to several life-threatening disease processes. Developing a point-of-care testing platform for the immediate and accurate detection of IL-6 concentrations could present valuable tool improving clinical management in patients with IL-6-mediated diseases. Drawing on an available biobank samples from 35 hospitalized COVID-19, novel quantum-magnetic sensing is used determine plasma concentrations. A strong correlation was observed between levels measured by...
Fever is a common presentation to urgent-care services and linked multiple disease processes. To rapidly determine the etiology of fever, improved diagnostic modalities are necessary. This prospective study 100 hospitalized febrile patients included both positive (FP) negative (FN) subjects in terms infection status 22 healthy controls (HC). We evaluated performance novel PCR-based assay measuring five host mRNA transcripts directly from whole blood differentiate infectious versus...
Abstract Background Several novel biomarkers have been studied in predicting clinical outcomes patients with COVID-19. Our study aimed to C-terminal proendothelin-1 (CT-proET-1) and Soluble fms-like tyrosine kinase-1 (sFlt-1) as predictors of a COVID-19 patient cohort from US-based multicenter trial. Methods Data the Boston Area Consortium (BACC) Bay Tocilizumab Trial was used this study. Patients biomarker determinations, not admitted intensive care unit (ICU) on admission, were included....
Abstract Background: Antimicrobial resistance (AMR) is a public health issue with rates increasing worldwide. Major contributing causes of AMR are the behaviors dispensing and purchasing antibiotics without prescription (DAWP PAWP), respectively among pharmacists clients, especially in low- middle-income countries. This study aims to investigate behavioral patterns related DAWP PAWP citizens Beirut, Lebanon. Methods: We conducted cross-sectional using questionnaires targeting stratified...