A5100384070- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer Cells and Metastasis
- Breast Implant and Reconstruction
- HER2/EGFR in Cancer Research
- Cancer-related Molecular Pathways
- Cancer and Skin Lesions
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer survivorship and care
- Cancer, Hypoxia, and Metabolism
- Global Cancer Incidence and Screening
- Healthcare and Venom Research
- Berberine and alkaloids research
- Glycosylation and Glycoproteins Research
- Shoulder Injury and Treatment
- Cancer Research and Treatments
- Anesthesia and Pain Management
- Estrogen and related hormone effects
- Bone health and treatments
- Traditional Chinese Medicine Studies
- Educational Reforms and Innovations
- Acupuncture Treatment Research Studies
- Medical Research and Treatments
University of Copenhagen
2010-2024
Jeonbuk National University
2024
Catholic University of Korea
2017-2023
Seoul St. Mary's Hospital
2017-2023
Pusan National University
2021
Gachon University
2016
Sangji University
2015
Samsung Medical Center
2011-2013
Sungkyunkwan University
2011-2013
Chung-Ang University
2011
Abstract Hypoxia, a feature common to most solid tumors, is known regulate many aspects of tumorigenesis. Recently, it was suggested that hypoxia increased the size cancer stem-cell (CSC) subpopulations and promoted acquisition CSC-like phenotype. However, candidate hypoxia-regulated mediators specifically relevant stemness-related functions colorectal CSCs have not been examined in detail. In present study, we showed self-renewal potential CSCs. Through various vitro studies, found...
Abstract Organoid cultures are increasingly used to model human cancers experimentally with a view tailoring personalized medicine and predicting drug responses. Breast cancer is no exception, but in particular, primary breast poses some inherent difficulties due the frequent presence of residual non-malignant cells biopsies. We originally developed an assay for distinction between malignant structures organoid (Petersen et al., Proc Natl Acad Sci (USA) 89(19):9064–8, 1992). Here, we apply...
The pericapsular nerve group (PENG) block was recently suggested as a regional technique for managing acute pain after hip surgery. However, few anatomical studies have confirmed the spread of injectate during PENG block. This cadaver study aimed to analyze target nerves single-injection ultrasound-guided block.Ultrasound-guided with 3 different volumes (10, 20, or 30 mL) performed in 18 cadavers. Injectate by volume first evaluated on computed tomography, followed dissection. dye over...
Medullary breast carcinomas (MBC) have been known to represent a rare cancer subtype associated with more favorable prognosis than invasive ductal (IDC). The purpose of this study was compare the clinicopathologic characteristics and outcomes MBC those IDC.
Background/Aims: Berberine (BBR) is an isoquinoline alkaloid and beneficial for the anticancer effect on a variety of human tumor cells. However, BBR's anti-angiogenesis property its clinical potential as inhibitor angiogenesis in breast cancer cells have not been fully elucidated. Here, we investigated BBR TPA-induced VEGF fibronectin (FN) well VEGF-induced FN Methods: The secretion protein was detected by ELISA. Fibronectin mRNA expression analyzed Real-Time PCR western blotting,...
Invasive pleomorphic lobular carcinoma (IPLC) is a very rare and distinct morphological variant of invasive (ILC), characterized by nuclear atypia pleomorphism contrasted with the cytologic uniformity ILC. This study evaluated clinicopathologic characteristics prognosis IPLC compared ductal (IDC).We retrospectively reviewed medical records 35 patients 6,184 IDC, not otherwise specified. We characteristics, relapse-free survival (RFS) disease specific (DSS) who were surgically treated between...
Tubular carcinoma (TC) of the breast is an uncommon histological subtype invasive cancer with excellent prognosis compared standard ductal carcinoma. Recent studies suggested a possible precursor role for low grade in situ (DCIS) development TC. The goal this analysis was to understand clinicopathologic features and outcomes TC by comparing DCIS.A retrospective review identified 70 patients 1,106 DCIS between 1995 2011. Student t-test Fisher exact test were used compare characteristics those...
Objective. Genetic factors account for more than 90% of overall susceptibility to ankylosing spondylitis (AS), and recent studies have focused on non-major histocompatibility complex genes. Vitamin D binding protein (DBP) is a highly polymorphic that transports vitamin its metabolites. In addition sterol capacity, DBP has many other roles in the inflammatory immune systems, been reported be associated with autoimmune diseases. We investigated association between polymorphisms AS. Methods....
The frequency of immediate breast reconstruction (IBR) is increasing, and the types used are diverse. Adjuvant chemotherapy a life-saving intervention in selected high-risk cancer patients. aim our study was to determine how IBR type affect timing initiation chemotherapy.We obtained data from female patients treated by mastectomy with (IBR group) without (mastectomy only who received adjuvant between January 1, 2008, December 31, 2010. We retrospectively collected including patient...
Arthralgia is the most common side effect in breast cancer patients receiving aromatase inhibitor (AI) therapy. Few studies have evaluated risk factors, onset, and incidence of musculoskeletal pain these patients. This study identifies factors AI-related severe arthralgia their prevalence.All clinical pathological records postmenopausal diagnosed with invasive using AI at Samsung Medical Center from January 2005 to November 2007 were reviewed. Multivariate logistic regression analyses...
Breast cancer diagnosis and treatment often produce stress in patients. Anxiety is one of the most prevalent psychological symptoms perceived by breast This study aims to evaluate temporal patterns anxiety find factors associated with persistent during treatment.This prospective cohort study. Between July 2010 2011, we recruited patients nonmetastatic who were expected receive adjuvant chemotherapy (n = 411) from 2 hospitals Seoul, Korea. was measured using Hospital Depression Scale.The mean...
Abstract OBJECTIVE To evaluate the diagnostic value of pulmonary-vein-to-pulmonary-artery ratio (PV:PA) in dogs with myxomatous mitral valve degeneration (MMVD), classified according to American College Veterinary Internal Medicine (ACVIM) consensus guidelines. ANIMALS 80 client-owned either MMVD (n = 65) or no cardiovascular disease (control group; n 15) between August 5, 2020, and July 19, 2023. METHODS This is a retrospective study. Dogs were ACVIM Echocardiograms, thoracic radiographs,...
The clinical meaning of intramammary lymph nodes (iMLNs) is uncertain. We wanted to describe the characteristics and understand implications iMLNs detected by sentinel LN biopsy (SLNB).We reviewed clinical, radiological pathological records women diagnosed with invasive carcinoma breast at Samsung Medical Center between January 2001 2011. A total 69 patients were identified, SLNB was performed in 31 patients.Of included study, 22 (31.9%) had metastases iMLNs. presence lymphovascular invasion...
For tracking the primo vascular system, we observed vessels in vivo situ using lipopolysaccharide (LPS) response lymphatic of a rabbit. Injection LPS (200 μg/kg) into lymph nodes resulted greatly stained vessels, which were swollen some cases. We able to obtain comparative images through alcian blue and diaminobenzidine staining, clearly showed different morphologies vessels. The mechanism causing injected is still unclear; however, these results might be first attempt at giving an...
IBTR! 2.0 is a web-based nomogram that predicts the 10-year ipsilateral breast tumor recurrence (IBTR) rate after breast-conserving therapy. We validated this in Korean patients.The was tested for 520 patients, who underwent surgery followed by radiation Predicted and observed outcomes were compared entire cohort each group, predefined nomogram-predicted risks: group 1, <3%; 2, 3% to 5%; 3, 5% 10%; 4, >10%.In overall 10 year predicted estimates of IBTR 5.22% 5.70% (p=0.68). In (n=124), 2.25%...
To investigate the effects of continuous systemic administration esmolol on intraocular pressure (IOP) during laparoscopic and robotic surgeries for recto-sigmoid cancer in a steep Trendelenburg position.A total 50 patients undergoing surgery position were included. Patients (E) group received 0.25 mg/kg IV loading dose before anesthesia, followed by an infusion 15 μg/kg/min throughout operation. saline (S) infused with same volume normal saline. IOP ocular perfusion measured 16 times:...