A5100731703- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Cell Adhesion Molecules Research
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related molecular mechanisms research
- Electrospun Nanofibers in Biomedical Applications
- Biological Activity of Diterpenoids and Biflavonoids
- HER2/EGFR in Cancer Research
- Dementia and Cognitive Impairment Research
- Glaucoma and retinal disorders
- Phytochemicals and Antioxidant Activities
- Bone Metabolism and Diseases
- Retinal Diseases and Treatments
- Ginger and Zingiberaceae research
- Bone health and treatments
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Cerebrospinal fluid and hydrocephalus
- Radiomics and Machine Learning in Medical Imaging
- Angiogenesis and VEGF in Cancer
- Chemokine receptors and signaling
- Intracerebral and Subarachnoid Hemorrhage Research
- Seaweed-derived Bioactive Compounds
- Engineering Technology and Methodologies
- Hearing, Cochlea, Tinnitus, Genetics
Samsung Medical Center
2013-2024
Soonchunhyang University
2024
Sungkyunkwan University
2012-2024
Chonnam National University
2024
Kyung Hee University Medical Center
2013-2021
Samsung (South Korea)
2015-2016
Mesenchymal stem cells (MSCs) have the potential to be a viable therapy against various diseases due their paracrine effects, such as secretion of immunomodulatory, trophic and protective factors. These are known distributed within organs tissues. Although they possess same characteristics, MSCs from different sources believed potentials patterns, which may influence therapeutic effects in disease environments. We characterized protein secretome adipose (AD), bone marrow (BM), placenta (PL),...
To evaluate the long-term effect of Ginkgo biloba extract (GBE) on progression visual field (VF) defects in patients with normal tension glaucoma (NTG).Forty-two eyes 42 treated NTG who received 80 mg GBE 2 times daily and had at least 5 VF tests using Humphrey Visual Field Analyzer for more than a 4-year period before after treatment were evaluated this retrospective study. We change rate mean deviation (MD), pattern standard (PSD), index (VFI) treatment. The time course total 10 zones...
Inflammation is a key regulatory process in cancer development. Prolonged exposure of breast tumor cells to inflammatory cytokines leads epithelial‐mesenchymal transition, which the principal mechanism involved metastasis and invasion. Interleukin (IL)‐1β major cytokine variety tumors. To date, IL‐1β‐induced cell migration invasion has not been fully elucidated. Here, we investigated effect zerumbone (ZER) on cells. The levels IL‐8 matrix metalloproteinase (MMP)‐3 mRNA were analyzed by...
Aberrant transforming growth factor-β (TGF-β) plays an important role in the development of cancer such as tumor metastasis and invasion. TGF-β-responsive gene signature is highly activated chemotherapy-treated triple negative breast (TNBC). Here, we investigated effect zerumbone (ZER) on TGF-β1 signaling pathway tumorigenecity TNBC cells. Our results showed that level mRNA expression cell invasiveness were higher cells than non-TNBC On other hand, motility was completely suppressed by...
The aim of this study was to track the migration human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) administered through a single intravenous injection and observe consequential therapeutic effects in transgenic Alzheimer's disease mouse model. Ten-month-old APP/PS1 mice received total 1×10 lateral tail vein were killed 1, 4, 7 days after administration. On basis immunohistochemical analysis, hUCB-MSCs not detected brain at any time points. Instead, most injected found be...
To determine the risk factors of visual field (VF) progression in relatively low and high intraocular pressure (IOP) groups normal tension glaucoma (NTG) patients to compare rate VF defects between 2 groups.Forty-nine eyes 49 NTG with untreated IOP ≤15 mm Hg (group A) matched by age baseline mean deviation (MD) who had >15 B) were included this retrospective chart review study. All followed >5 years. Risk for evaluated using Cox proportional hazards models each group, separately. Changes...
Background/Aims: Berberine (BBR) is an isoquinoline alkaloid and beneficial for the anticancer effect on a variety of human tumor cells. However, BBR's anti-angiogenesis property its clinical potential as inhibitor angiogenesis in breast cancer cells have not been fully elucidated. Here, we investigated BBR TPA-induced VEGF fibronectin (FN) well VEGF-induced FN Methods: The secretion protein was detected by ELISA. Fibronectin mRNA expression analyzed Real-Time PCR western blotting,...
Interleukin-8 (IL-8) serves as a prognostic marker for breast cancer, and its expression level correlates with metastatic cancer poor prognosis. Here, we investigated the levels of IL-8 in variety cells regulatory mechanism triple-negative (TNBC) cells. Our results showed that correlated positively overall survival basal-type patients. The mRNA protein secretion were significantly increased TNBC compared non-TNBC In addition, invasiveness was dramatically by treatment then augmented...
Transforming growth factor-beta (TGF-β) is a multifunctional cytokine that regulates many biological events including cell motility and angiogenesis. Here, we investigated the role of elevated TGF-β2 level in triple negative breast cancer (TNBC) cells inhibitory effect silibinin on action TNBC cells. Breast patients with high expression have poor prognosis. The levels increased significantly compared those non-TNBC In addition, motility-related genes such as fibronectin (FN) matrix...
Mesenchymal stem cells (MSCs) have a promising role as therapeutic agent for neurodegenerative diseases such Alzheimer's disease (AD). Prior studies suggested that intra-arterially administered MSCs are engrafted into the brain in stroke or traumatic injury (TBI) animal models. However, controversial standpoint exists terms of integrity blood barrier (BBB) transgenic AD mice. The primary goal this study was to explore feasibility delivering human umbilical cord-blood derived mesenchymal...
Decreased hemoglobin levels increase the risk of developing dementia among elderly. However, underlying mechanisms that link decreased to incident still remain unclear, possibly due fact few studies have reported on relationship between low and neuroimaging markers. We, therefore, investigated relationships levels, cerebral small-vessel disease (CSVD), cortical atrophy in cognitively healthy women men.Cognitively normal (n = 1,022) men 1,018) who underwent medical check-ups magnetic...
Due to their widely known therapeutic benefits, mesenchymal stem cells have been proposed as a novel treatment option for wide range of diseases including Alzheimer's disease. To maximize these critical factors such delivery route, cell viability, and migration must be accounted for. Out the various routes brain, intracerebroventricular (ICV) route stands out due widespread distribution that can occur via cerebrospinal fluid flow. The major objective this present study was observe how...
Mesenchymal stem cells (MSCs) have emerged as one of the promising treatment options for Alzheimer's disease (AD). Although many studies investigated on efficacy MSCs in AD, how actually change following exposure to AD environment has not been studied extensively. In this study, we potential patient-cerebrospinal fluid (CSF) samples be used a formulation and its application therapeutics. When Wharton's jelly-derived mesenchymal (WJ-MSCs) were stored CSF patients, stemness WJ-MSCs was...
554 Background: Homologous recombination deficiency (HRD) in breast cancer is an actionable target, with treatment efficacy potentially linked to timely detection. Notably, BRCA1 and BRCA2 are key genes implicated HRD, their pathogenic germline mutations crucial criteria for the use of poly (ADP-ribose) polymerase inhibitors (PARPi). Although BRCA1/2 detectable only a small fraction (1-5%) cancers, recent whole-genome sequencing (WGS) studies have revealed that up 22% cancers also exhibit...
Background: Sex effects on the progression of Alzheimer’s disease (AD) have received less attention than other demographic factors, including onset age and education. Objective: The aim this study was to investigate whether sex affected cortical thinning in AD. Methods: We prospectively recruited 36 patients with early-stage AD 14 people normal cognition. All subjects were assessed magnetic resonance imaging at baseline, Year 1, 3, 5. performed thickness analyses using surface-based...