A5051908470- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and genetic disorders
- Stroke Rehabilitation and Recovery
- Neurological Disorders and Treatments
- Multiple Sclerosis Research Studies
- Brain Tumor Detection and Classification
- Intracerebral and Subarachnoid Hemorrhage Research
- Long-Term Effects of COVID-19
- Retinal Imaging and Analysis
- RNA regulation and disease
- Cardiovascular Health and Disease Prevention
- Intracranial Aneurysms: Treatment and Complications
- Neurological diseases and metabolism
- Atrial Fibrillation Management and Outcomes
- Genetic Neurodegenerative Diseases
- SARS-CoV-2 and COVID-19 Research
- CNS Lymphoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Moyamoya disease diagnosis and treatment
Chinese University of Hong Kong
2015-2024
Prince of Wales Hospital
2013-2024
Leiden University
2019
Therapeutics Clinical Research
2014-2015
Health Sciences Centre
2015
University of Toronto
2015
Sunnybrook Health Science Centre
2015
Trinity Health Grand Rapids
2015
Second Affiliated Hospital of Guangzhou Medical University
2015
Hong Kong Sanatorium and Hospital
2015
Background and Purpose— The National Institute of Neurological Disorders Stroke-Canadian Stroke Network Vascular Cognitive Impairment Harmonization working group proposed a brief cognitive protocol for screening vascular impairment. We investigated the validity, reliability, feasibility Montreal Assessment 5-minute (MoCA protocol) administered over telephone. Methods— Four items examining attention, verbal learning memory, executive functions/language, orientation were extracted from MoCA to...
Abstract Background We hypothesized that chronic brain changes are important substrates for incident dementia after stroke and transient ischemic attack (TIA). Methods compared clinical imaging features between patients with consecutive stroke/TIA (n = 88) without 925) at 3 to 6 months a stroke/TIA. Pittsburg compound B (PiB) positron emission tomography was performed in 50 patients, including those 37) 13) dementia. Results Age, history of diabetes mellitus, severity white matter (WMCs),...
Background and Purpose— We hypothesized that comorbid amyloid-beta (Aβ) deposition played a key role in long-term cognitive decline subjects with stroke/transient ischemic attack. Methods— recruited 72 impairment after attack to receive Carbon-11-labeled Pittsburgh compound B positron emission tomography. excluded known clinical Alzheimer’s disease. Those without disease–like Aβ were classified as mixed vascular (mVCI, n=14) pure VCI (pVCI, n=58), respectively. performed Mini-Mental State...
Patients surviving stroke without immediate dementia are at high risk of delayed-onset dementia. Mechanisms underlying complex and may involve vascular and/or neurodegenerative diseases.Dementia-free patients with transient ischemic attack (TIA; n = 919) were studied for 3 years prospectively, excluding those who developed to 6 months after TIA.Forty subjects (4.4%) during the study period. Imaging markers severe small vessel disease (SVD), namely presence ≥3 lacunes confluent white matter...
Abstract Introduction We compared the machine learning‐derived, MRI‐based Alzheimer's disease (AD) resemblance atrophy index (AD‐RAI) with plasma neurofilament light chain (NfL) level in predicting conversion of early AD among cognitively unimpaired (CU) and mild cognitive impairment (MCI) subjects. Methods recruited participants from Disease Neuroimaging Initiative (ADNI) who had following data: clinical features (age, gender, education, Montreal Cognitive Assessment [MoCA]), structural...
Understanding how symptomatic intracranial atherosclerotic disease (ICAD) evolves with current medical therapy may inform secondary stroke prevention.In a prospective academic-initiated study, we recruited 50 patients (mean age = 63.4 ± 9.0 years) acute strokes attributed to high-grade (≥70%) stenosis for 3-dimensional rotational angiograms before and after intensive 12 months. Treatment targets included low-density lipoprotein ≤ 70mg/dl, glycosylated hemoglobin (HbA1c) 6.5%, systolic blood...
Cases of iatrogenic cerebral amyloid angiopathy (CAA) have been increasingly reported recently, particularly those associated with neurosurgery. Preclinical studies shown taxifolin to be promising for treating CAA. We describe a young 42-year-old man history childhood traumatic brain injury that required craniotomy hematoma evacuation. He later presented recurrent lobar intracerebral hemorrhage (ICH) decades later, which was histologically confirmed Serial 11 C-Pittsburgh compound B positron...
Background The Montreal Cognitive Assessment (MoCA) is psychometrically superior over the Mini‐mental State Examination (MMSE) for cognitive screening in stroke or transient ischemic attack (TIA). It free clinical and research use. objective of this study to convert scores from MMSE MoCA MoCA‐5‐minute protocol (MoCA‐5 min) examine ability converted detecting impairment after TIA. Methods A total 904 patients were randomly divided into training ( n = 623) validation 281) samples matched...
Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age-related cognitive alterations, whereas none association with vascular risk factors.We evaluated 801 stroke- dementia-free elderlies baseline 3-year follow-up assessments. Regression analyses were used to assess functions PSMD. Simple mediation models study effect PSMD factors outcomes.PSMD was negatively associated processing speed at memory scores follow-up. The cognition...
To realize an individual-level risk evaluation of progression early Alzheimer's disease (AD), we applied AD resemblance atrophy index (AD-RAI) to differentiate the subjects at from normal (NC) mild cognitive impairment (MCI) and MCI AD. We included 183 with a two-year follow-up: 50 NC stable (NCs), 23 NC-to-MCI converters (NCc), (MCIs), 35 MCI-to-AD (MCIc), 25 (ADs). ANCOVA analyses were used identify baseline brain in compared non-converters. explore relative merits AD-RAI over individual...
We explored the association between cerebral microbleeds (CMBs) and cognitive impairment in patients with ischemic stroke/transient attack (TIA).A total of 488 stroke/TIA received magnetic resonance imaging. Montreal Cognitive Assessment (MoCA) was used to evaluate global function domains. The CMB quantity impact locations (strictly lobar, strictly deep, mixed regions) on were examined regression models adjustments for confounders.A 113 subjects (23.2%) had ≥1 CMB. Strictly CMBs identified...
The objectives of this study are 1) to examine the frequencies neuropsychiatric symptom clusters in patients with stroke or transient ischemic attack (TIA) by cognitive level and subtype; 2) evaluate effect demographic, clinical, neuroimaging measures chronic brain changes amyloid upon clusters.Hospital-based, cross-sectional study. 518 were administered Neuropsychiatric Inventory (NPI) 3-6 months post index admission. NPI symptoms classified into four (Behavioral Problems, Psychosis, Mood...
Background Leisure activity participation has been shown to lower risks of cognitive decline in non-stroke populations. However, effects leisure activities upon functions and risk dementia after stroke are unclear. The purpose this study is examine the recent past incident stroke. Methods Hospital-based, retrospective cohort study. 88 1,013 patients with or TIA having no prestroke were diagnosed have poststroke (PSD) 3–6 months Regular (≥3 times per week) intellectual, recreational, social...
Alzheimer’s disease (AD) was recently defined as a biological construct to reflect neuropathologic status, and both abnormal amyloid tau are required for diagnosis of AD. We aimed determine the proton MR spectroscopic (1H-MRS) patterns posterior cingulate in biologically A total 68 participants were included this study, comprising 37 controls, 16 early AD, 15 late who classified according their status presence hippocampal atrophy. Compared with AD showed lower N-acetylaspartate...
The authors hypothesized that both high and low pulse pressure (PP) may predict cognitive decline in stroke/transient ischemic attack (TIA) patients with white matter changes (WMCs). prospectively followed up 406 stroke/TIA confluent WMCs over 18 months. PP was measured at 3 to 6 months after categorized into four groups by quartile. Cognition assessed 15 using the Clinical Dementia Rating Mini-Mental State Examination (MMSE). Logistic regression showed first quartile of had a 5.9-fold...
Background: Magnetic resonance imaging (MRI) provides objective information about brain structural atrophy in patients with Alzheimer’s disease (AD). This multi-structural atrophic information, when integrated as a single differential index, has the potential to further elevate accuracy of AD identification from normal control (NC) compared conventional structure volumetric index. Objective: We herein investigated performance such an MRI-derived AD-Resemblance Atrophy Index (AD-RAI),...
Background The fimbria is a small white matter bundle that connects the hippocampus to rest of brain. Damage hippocampal gray established in Alzheimer's disease (AD), but fimbrial status pathogenesis AD unclear. AD‐related demyelination and iron deposition alter diamagnetic paramagnetic composition tissues, which can be measured by quantitative susceptibility mapping (QSM). Hypothesis associated with microstructural changes might detected QSM. Study type Retrospective cross‐sectional study....
Background Intracranial atherosclerotic disease (ICAD) is globally a major ischaemic stroke subtype with high recurrence. Understanding the morphology of symptomatic ICAD plaques, largely unknown by far, may help identify vulnerable lesions prone to relapse. Methods We prospectively recruited patients acute or transient attack attributed high-grade (60%–99% stenosis). Plaque morphological parameters were assessed in three-dimensional rotational angiography, including surface contour, luminal...
Alzheimer's Disease-resemblance atrophy index (AD-RAI) is an MRI-based machine learning derived biomarker that was developed to reflect the characteristic brain associated with AD. Recent study showed AD-RAI (≥0.5) had best performance in predicting conversion from mild cognitive impairment (MCI) dementia and cognitively unimpaired (CU) MCI. We aimed validate of detecting preclinical prodromal recruited 128 subjects (MCI=50, CU=78) two cohorts: CU-SEEDS ADNI. Amyloid (A+) tau (T+) status...
We performed a cross-sectional study in 123 Chinese multiple sclerosis patients residing Hong Kong to evaluate their anti-John Cunningham virus status using STRATIFY JCV DxSelect assays. Anti-John antibody was present 98/123 (80%) subjects, among which 75/98 (77%) had an index ≥1.5. seropositivity not correlated with age, disease duration, Expanded Disability Status Scale scores, types of (relapsing vs progressive), or disease-modifying treatments used. found very high seroprevalence and...
Background Depicting the time trends of ischemic stroke subtypes may inform healthcare resource allocation on etiology-based prevention and treatment. Aim To reveal evolving from 2004 to 2018. Methods We determined etiologies consecutive first-ever transient attack or patients admitted a regional hospital in Hong Kong analyzed age-standardized incidences two-year recurrence rate major subtypes. Results Among 6940 2018, incidence declined 187.0 127.4 per 100,000 population (p < 0.001),...